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Image Search Results
Journal: Cancer Immunology, Immunotherapy : CII
Article Title: Generation and characterization of the first inhibitory antibody targeting tumour-associated carbonic anhydrase XII
doi: 10.1007/s00262-011-0980-z
Figure Lengend Snippet: Inhibition data against isoforms CA I–XV with 6A10, MAB2190 and acetazolamide (AAZ)
Article Snippet: The CA XII-specific
Techniques: Inhibition
Journal: Cancers
Article Title: Carbonic Anhydrase Inhibitors Induce Ferroptosis through Inhibition of AKT/FTH1 Signaling in Ewing Sarcoma Tumor Cells
doi: 10.3390/cancers15215225
Figure Lengend Snippet: Identification of CA-mRNAs in the tissue of ES patients. ( A ) Box plots show the level of CA-mRNA expression in the ES tumor tissue of patients with relapse (red bar) and no relapse (black bar). Two-way ANOVA, Bonferroni test, p = 0.0088 for CA2 mRNA; ( B ) Kaplan–Meier plots for overall survival of the patients with ES using the GSE63155 dataset. Patients were classified according to CA2 mRNA expression (as described in Methods section). Log-rank test p value 0.081; ( C ) Box plots show the level of CAI, CAII, CAVIII, CAX and CAXII protein expression using primary paraffin-embedded ES tumor sections (N = 9) via immunohistochemistry. Kruskal–Wallis test p = 0.0031; PPI network constructed using STRING software (STRING: functional protein association networks ( www.string-db.org )). for the 50 most differentially expressed and top21 ( D ) proteins exhibiting highest degree of correlation with CAII (Spearman degree of correlation between 7.2 × 10 14 till 5.2 × 10 14 ) were used.
Article Snippet: Prior to staining, the working dilution for CAI (Cusabio, Cat # CSB-PA004364ESR1HU, 1/200), CAII (FineTest, Cat #FNab01161, 1/200),
Techniques: Expressing, Immunohistochemistry, Construct, Software, Functional Assay