Journal: Annals of Medicine

Article Title: Neutralizing antibodies against SARS-CoV-2 of vaccinated healthcare workers in Taiwan

doi: 10.1080/07853890.2024.2442533

Figure Lengend Snippet: Neutralizing antibody levels between groups and post-vaccination days. Analysis of neutralizing antibody levels using the cPass SARS-CoV2 neutralizing antibody assay after 2 doses of vaccination. (A) Comparison of neutralizing antibody levels between 3 groups of participants who received the vaccine (1st and 2nd dose of vaccine combinations) from AstraZeneca (AZD1222) and Moderna (mRNA-1273) vaccines. (B) Longitudinal analysis of the correlation between neutralizing antibody levels and post-vaccination days who received the AZD1222 + AZD1222 vaccine group (blue color). (C). Longitudinal analysis of the correlation between neutralizing antibody levels and post-vaccination days who received the AZD1222 + mRNA-1273 vaccine group(green color). (D) Longitudinal analysis of the correlation between neutralizing antibody levels and post-vaccination days who received the mRNA-1273 + mRNA1273 vaccine group (red color). The difference in neutralizing antibody levels between groups was analyzed using the Kruskal-Wallis test (ns: not significant and **** p < 0.0001). Data were expressed as median and IQR. The Pearson correlation was used for the analysis of the correlation between neutralizing antibody levels and post-vaccination days.

Article Snippet: A study in Thailand with other mRNA vaccine boosters (Pfizer-BioNTech/BNT) also shows higher antibody levels than AZD1222 boosters in healthcare workers [ ].

Techniques: Comparison, Vaccines

Journal: Annals of Medicine

Article Title: Neutralizing antibodies against SARS-CoV-2 of vaccinated healthcare workers in Taiwan

doi: 10.1080/07853890.2024.2442533

Figure Lengend Snippet: Neutralizing antibody levels and age. Correlation of antibody levels and age, measured using cPass SARS-CoV-2 neutralizing antibody assay after 2 doses of vaccination with age: (A) AZD1222 + AZD1222 vaccine group (blue color). (B) AZD1222 + mRNA-1273 vaccine group (green color). (C) mRNA-1273 + mRNA-1273 vaccine group (red color). The Pearson correlation was used for the analysis of the correlation between neutralizing antibody levels and age.

Article Snippet: A study in Thailand with other mRNA vaccine boosters (Pfizer-BioNTech/BNT) also shows higher antibody levels than AZD1222 boosters in healthcare workers [ ].

Techniques:

Journal: PLoS ONE

Article Title: Comparison of Antibody Repertoires Produced by HIV-1 Infection, Other Chronic and Acute Infections, and Systemic Autoimmune Disease

doi: 10.1371/journal.pone.0016857

Figure Lengend Snippet: Comparison of CDR-H3 length, SM and distance from D H of V H genes among MAbs of known Ag specificity associated with HIV infection ( Table 1A ), chronic infection (ChI), acute infection (AcI) or systemic autoimmune disease (SAD) ( Table 1B ), and self vs. non-self ( Table 1C ).

Article Snippet: This lack of shared features between the SAD and bNt MAbs (or ChI MAbs in general) suggests that the bNt MAbs against HIV are probably not drawn from an initial pool of autoimmune B cells bearing long CDR-H3s, as previously hypothesized , , ; were that the case, then the bNt MAbs would be expected to be similar to the SAD MAbs but not the ChI ones.

Techniques: Comparison, Infection

Journal: PLoS ONE

Article Title: Comparison of Antibody Repertoires Produced by HIV-1 Infection, Other Chronic and Acute Infections, and Systemic Autoimmune Disease

doi: 10.1371/journal.pone.0016857

Figure Lengend Snippet: HIV Mabs are divided into three categories: bNt HIV MAbs, all HIV MAbs with the bNt HIV MAbs removed ( i.e., non-bNt HIV MAbs), and ChI MAbs with the HIV MAbs removed ( i.e ., non-HIV ChI MAbs). Arrows indicate the mean for each category. Distribution of CDR-H3 length for more than 4000 Abs compiled from IMGT and Kabat databases is included in Figs. 1–3, as a control comparison (blue line). The average CDR-H3 length of the 425 Ag-specific MAbs was 16.3 aa, which is higher than the 15.2-aa mean reported for 4751 expressed V H sequences compiled from the Kabat and IMGT databases by Zemlin et al. ; this may reflect that our data set included a higher proportion of ChI Abs, both HIV and non-HIV.

Article Snippet: This lack of shared features between the SAD and bNt MAbs (or ChI MAbs in general) suggests that the bNt MAbs against HIV are probably not drawn from an initial pool of autoimmune B cells bearing long CDR-H3s, as previously hypothesized , , ; were that the case, then the bNt MAbs would be expected to be similar to the SAD MAbs but not the ChI ones.

Techniques: Control, Comparison

Journal: PLoS ONE

Article Title: Comparison of Antibody Repertoires Produced by HIV-1 Infection, Other Chronic and Acute Infections, and Systemic Autoimmune Disease

doi: 10.1371/journal.pone.0016857

Figure Lengend Snippet: A. Distribution of CDR-H3 length for ChI, SAD, and AcI MAbs. B. Distribution of CDR-H3 length for ChI anti-protein, SAD anti-protein, AcI anti-protein, SAD anti-non-protein, and AcI anti-non-protein MAbs. Arrows indicate the means for each category. Control MAbs (blue line) are included for comparison .

Article Snippet: This lack of shared features between the SAD and bNt MAbs (or ChI MAbs in general) suggests that the bNt MAbs against HIV are probably not drawn from an initial pool of autoimmune B cells bearing long CDR-H3s, as previously hypothesized , , ; were that the case, then the bNt MAbs would be expected to be similar to the SAD MAbs but not the ChI ones.

Techniques: Control, Comparison

Journal: PLoS ONE

Article Title: Comparison of Antibody Repertoires Produced by HIV-1 Infection, Other Chronic and Acute Infections, and Systemic Autoimmune Disease

doi: 10.1371/journal.pone.0016857

Figure Lengend Snippet: Somatic mutations and V H -gene distance of MAbs grouped according to short (< = 13aa), medium (14-18 aa) or long (> = 19aa) CDR-H3 length.

Article Snippet: This lack of shared features between the SAD and bNt MAbs (or ChI MAbs in general) suggests that the bNt MAbs against HIV are probably not drawn from an initial pool of autoimmune B cells bearing long CDR-H3s, as previously hypothesized , , ; were that the case, then the bNt MAbs would be expected to be similar to the SAD MAbs but not the ChI ones.

Techniques: