atm-3507 Search Results


atm3507  (MedChemExpress)
94
MedChemExpress atm3507
Fig. 2. TPM3.1 inhibition leads to a change in cell morphology in bovine and human P2 cells. (A) Light microscopy images of bovine and human chondrocytes treated with pharmacological TPM3.1 inhibitors, TR100 and <t>ATM3507,</t> for 1 day. (B) Quantification of light microscopy images showing that Tpm 3.1 inhibition decreases cell area and elongation in bovine (left) and human (right) P2 chondrocytes. ***, p < 0.001 as compared to DMSO control.
Atm3507, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/atm-3507/ATM-3507/pm38823166-98-14-15
Average 94 stars, based on 1 article reviews
atm3507 - by Bioz Stars, 2026-09
94/100 stars
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atm-3507  (MuseChem Chemicals)
N/A
ATM-3507(CAT: I020062) is a potent small-molecule tropomyosin inhibitor that demonstrates micromolar antiproliferative activity across multiple cancer cell lines, with IC₅₀ values ranging from approximately 3.8 to 6.8 μM in neuroblastoma and melanoma models. Its activity
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atm 3507  (Atomwise Inc)
86
Atomwise Inc atm 3507
Fig. 2. TPM3.1 inhibition leads to a change in cell morphology in bovine and human P2 cells. (A) Light microscopy images of bovine and human chondrocytes treated with pharmacological TPM3.1 inhibitors, TR100 and <t>ATM3507,</t> for 1 day. (B) Quantification of light microscopy images showing that Tpm 3.1 inhibition decreases cell area and elongation in bovine (left) and human (right) P2 chondrocytes. ***, p < 0.001 as compared to DMSO control.
Atm 3507, supplied by Atomwise Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/atm-3507/3507+atm/pmc12472608-23-0-2
Average 86 stars, based on 1 article reviews
atm 3507 - by Bioz Stars, 2026-09
86/100 stars
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atm-3507 trihydrochloride  (TargetMol)
N/A
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atm-3507  (TargetMol)
N/A
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atm-3507  (Biosynth Carbosynth)
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atm-3507  (Aladdin Scientific Corporation)
N/A
ATM-3507 is a potent tropomyosin inhibitor with IC 50 s from 3.83-6.84 μM in human melanoma cell lines.In VitroThe cell lines differ in their relative expression of Tpm3.1 as well as in the expression of
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Image Search Results


Fig. 2. TPM3.1 inhibition leads to a change in cell morphology in bovine and human P2 cells. (A) Light microscopy images of bovine and human chondrocytes treated with pharmacological TPM3.1 inhibitors, TR100 and ATM3507, for 1 day. (B) Quantification of light microscopy images showing that Tpm 3.1 inhibition decreases cell area and elongation in bovine (left) and human (right) P2 chondrocytes. ***, p < 0.001 as compared to DMSO control.

Journal: European journal of cell biology

Article Title: Targeting F-actin stress fibers to suppress the dedifferentiated phenotype in chondrocytes.

doi: 10.1016/j.ejcb.2024.151424

Figure Lengend Snippet: Fig. 2. TPM3.1 inhibition leads to a change in cell morphology in bovine and human P2 cells. (A) Light microscopy images of bovine and human chondrocytes treated with pharmacological TPM3.1 inhibitors, TR100 and ATM3507, for 1 day. (B) Quantification of light microscopy images showing that Tpm 3.1 inhibition decreases cell area and elongation in bovine (left) and human (right) P2 chondrocytes. ***, p < 0.001 as compared to DMSO control.

Article Snippet: After 24 hours, cells were exposed to the pharmacological TPM3.1 inhibitors TR100 (MilliporeSigma) or ATM3507 (MedChemExpress; Monmouth Junction, NJ, USA).

Techniques: Inhibition, Light Microscopy, Control

Fig. 3. TPM3.1 inhibition ablates F-actin stress fibers and promotes cortical F-actin organization in bovine P2 cells. (A) Lower magnification (20x objective) confocal microscopy images of bovine P2 cells treated with pharmacological TPM3.1 inhibitors, TR100 or ATM3507, for 1 day. (B) Higher magnification (63x objective) of regions in A (white dashed boxes) showing TR100 treatment in bovine cells leads to a cortical actin rearrangement. Cells stained for F-actin (Phalloidin; Red), TPM3.1 (Antibody 2G10.2; Green), and Nuclei (Hoechst; Blue). (C) Line scan analysis of lines (pink dashed) in panel B, demonstrating TR100 or ATM3507 treatment de creases colocalization between TPM3.1 with F-actin as compared to DMSO control. There is also less cortical TPM3.1 as compared to P0 cells (Fig. 1A).

Journal: European journal of cell biology

Article Title: Targeting F-actin stress fibers to suppress the dedifferentiated phenotype in chondrocytes.

doi: 10.1016/j.ejcb.2024.151424

Figure Lengend Snippet: Fig. 3. TPM3.1 inhibition ablates F-actin stress fibers and promotes cortical F-actin organization in bovine P2 cells. (A) Lower magnification (20x objective) confocal microscopy images of bovine P2 cells treated with pharmacological TPM3.1 inhibitors, TR100 or ATM3507, for 1 day. (B) Higher magnification (63x objective) of regions in A (white dashed boxes) showing TR100 treatment in bovine cells leads to a cortical actin rearrangement. Cells stained for F-actin (Phalloidin; Red), TPM3.1 (Antibody 2G10.2; Green), and Nuclei (Hoechst; Blue). (C) Line scan analysis of lines (pink dashed) in panel B, demonstrating TR100 or ATM3507 treatment de creases colocalization between TPM3.1 with F-actin as compared to DMSO control. There is also less cortical TPM3.1 as compared to P0 cells (Fig. 1A).

Article Snippet: After 24 hours, cells were exposed to the pharmacological TPM3.1 inhibitors TR100 (MilliporeSigma) or ATM3507 (MedChemExpress; Monmouth Junction, NJ, USA).

Techniques: Inhibition, Confocal Microscopy, Staining, Control