as1708727 Search Results


as1708727  (MedChemExpress)
91
MedChemExpress as1708727

As1708727, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/as1708727/product/MedChemExpress
Average 91 stars, based on 1 article reviews
as1708727 - by Bioz Stars, 2026-02
91/100 stars
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foxo1 inhibitor as1708727  (Merck & Co)
90
Merck & Co foxo1 inhibitor as1708727
(A–B) Human brain endothelial cells were transfected with siM3 or sic duplexes, processed for western-blots three days later, as indicated. (B) Alternatively, cells were stained for <t>FoxO1</t> (green) and analyzed by confocal microscopy. Nuclei were counterstained with DAPI (blue). Graph showed the percentage of FoxO1-positive nuclei. Scale bars: 10 μm. n>200 cells, T-test: *, p<0.05. (C) Cells were exposed to the FoxO1 inhibitor <t>(AS1708727,</t> iFoxo, 100 nM, three days) or vehicle (dmso) and processed for RT-PCR. (D) Permeability assays were performed in non-stimulated (ctl), histamine- (Hista) or IL-8-challenged HUVECs pre-treated with dmso and iFoxo. All panels are representative of at least three independents experiments. ANOVA test *, p<0.05; ***, p<0.001.
Foxo1 Inhibitor As1708727, supplied by Merck & Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/foxo1 inhibitor as1708727/product/Merck & Co
Average 90 stars, based on 1 article reviews
foxo1 inhibitor as1708727 - by Bioz Stars, 2026-02
90/100 stars
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chemicals 2-cyclopentyl-n-{2,4-dichloro-3-[(isoquinolin-5-yloxy)methyl] phenyl}-n-methylacetamide (as1708727)  (Astellas)
90
Astellas chemicals 2-cyclopentyl-n-{2,4-dichloro-3-[(isoquinolin-5-yloxy)methyl] phenyl}-n-methylacetamide (as1708727)
(A–B) Human brain endothelial cells were transfected with siM3 or sic duplexes, processed for western-blots three days later, as indicated. (B) Alternatively, cells were stained for <t>FoxO1</t> (green) and analyzed by confocal microscopy. Nuclei were counterstained with DAPI (blue). Graph showed the percentage of FoxO1-positive nuclei. Scale bars: 10 μm. n>200 cells, T-test: *, p<0.05. (C) Cells were exposed to the FoxO1 inhibitor <t>(AS1708727,</t> iFoxo, 100 nM, three days) or vehicle (dmso) and processed for RT-PCR. (D) Permeability assays were performed in non-stimulated (ctl), histamine- (Hista) or IL-8-challenged HUVECs pre-treated with dmso and iFoxo. All panels are representative of at least three independents experiments. ANOVA test *, p<0.05; ***, p<0.001.
Chemicals 2 Cyclopentyl N {2,4 Dichloro 3 [(Isoquinolin 5 Yloxy)Methyl] Phenyl} N Methylacetamide (As1708727), supplied by Astellas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/chemicals 2-cyclopentyl-n-{2,4-dichloro-3-[(isoquinolin-5-yloxy)methyl] phenyl}-n-methylacetamide (as1708727)/product/Astellas
Average 90 stars, based on 1 article reviews
chemicals 2-cyclopentyl-n-{2,4-dichloro-3-[(isoquinolin-5-yloxy)methyl] phenyl}-n-methylacetamide (as1708727) - by Bioz Stars, 2026-02
90/100 stars
  Buy from Supplier

Image Search Results


Journal: iScience

Article Title: GM-CSF receptor/SYK/JNK/FOXO1/CD11c signaling promotes atherosclerosis

doi: 10.1016/j.isci.2023.107293

Figure Lengend Snippet:

Article Snippet: The cells were incubated with the following inhibitors: AS1842856 (HY-100596; Medchem Express), AS1708727 (HY-123046; MedChemExpress), Compound C (ab120843; Abcam), SB203580 (AG-CR1-0030; AdipoGen, San Diego, CA, USA), SP600125 (10010466; Cayman Chemicals), and XMU-MP-1 (HY-100526; MedChemExpress).

Techniques: Virus, Recombinant, Red Blood Cell Lysis, Staining, Luminescence Assay, Chromatin Immunoprecipitation, Bradford Protein Assay, Expressing, Plasmid Preparation, Software, Membrane, Blocking Assay, Isolation, Transfection, Extraction, Protease Inhibitor, Western Blot

(A–B) Human brain endothelial cells were transfected with siM3 or sic duplexes, processed for western-blots three days later, as indicated. (B) Alternatively, cells were stained for FoxO1 (green) and analyzed by confocal microscopy. Nuclei were counterstained with DAPI (blue). Graph showed the percentage of FoxO1-positive nuclei. Scale bars: 10 μm. n>200 cells, T-test: *, p<0.05. (C) Cells were exposed to the FoxO1 inhibitor (AS1708727, iFoxo, 100 nM, three days) or vehicle (dmso) and processed for RT-PCR. (D) Permeability assays were performed in non-stimulated (ctl), histamine- (Hista) or IL-8-challenged HUVECs pre-treated with dmso and iFoxo. All panels are representative of at least three independents experiments. ANOVA test *, p<0.05; ***, p<0.001.

Journal: Febs Letters

Article Title: The E3 ubiquitin ligase MARCH3 controls the endothelial barrier

doi: 10.1002/1873-3468.12417

Figure Lengend Snippet: (A–B) Human brain endothelial cells were transfected with siM3 or sic duplexes, processed for western-blots three days later, as indicated. (B) Alternatively, cells were stained for FoxO1 (green) and analyzed by confocal microscopy. Nuclei were counterstained with DAPI (blue). Graph showed the percentage of FoxO1-positive nuclei. Scale bars: 10 μm. n>200 cells, T-test: *, p<0.05. (C) Cells were exposed to the FoxO1 inhibitor (AS1708727, iFoxo, 100 nM, three days) or vehicle (dmso) and processed for RT-PCR. (D) Permeability assays were performed in non-stimulated (ctl), histamine- (Hista) or IL-8-challenged HUVECs pre-treated with dmso and iFoxo. All panels are representative of at least three independents experiments. ANOVA test *, p<0.05; ***, p<0.001.

Article Snippet: Reagents and Antibodies FoxO1 inhibitor AS1708727 was from Merck and used at 100 nM.

Techniques: Transfection, Western Blot, Staining, Confocal Microscopy, Reverse Transcription Polymerase Chain Reaction, Permeability