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Image Search Results
Journal: Molecules
Article Title: Design of Potent and Controllable Anticoagulants Using DNA Aptamers and Nanostructures
doi: 10.3390/molecules21020202
Figure Lengend Snippet: Cycles of antidote/retriever regulation in aPTT assays using ( A ) Apt P; ( B ) 2HT-BnPn and ( C ) 2HT-BPPB. Addition of antidote reverses anticoagulation to less than 10%, whereas addition of retriever I restores it to almost 80%. Retriever II reverses anticoagulation back to less than 10%. The % anticoagulant activity is calculated as described in Materials and Methods. Error bars represent SEM. Raw clotting times are provided in the .
Article Snippet: CaCl 2 solution and
Techniques: Activity Assay, Coagulation
Journal: Cell chemical biology
Article Title: Anti-PEG antibodies inhibit the anticoagulant activity of PEGylated aptamers
doi: 10.1016/j.chembiol.2019.02.001
Figure Lengend Snippet: KEY RESOURCE TABLE
Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies Chicken polyclonal anti-human IgG-HRP Abcam Ca# 6864 Rabbit anti-monkey IgG-HRP Sigma-Aldrich Ca# 2054 Mouse anti-PEG Life Diagnostics Ca# ID9-6 Bacterial and Virus Strains Biological Samples Rhesus monkey plasma Tarantal, UC Davis N/A Human plasma samples Duke University; Department of Medicine N/A Pooled normal human plasma George King Biomedical Ca# 0010-1 Chemicals, Peptides, and Recombinant Proteins Human Factor IXa Haematologic Technologies Ca# HCIXA-0050 Adenosine deaminase bovine (ADA) Sigma-Aldrich A5168; CAS: 9026-93-1 ADAGEN (pegademase bovine) Lediant Biosciences http://www.adagen.com/pdf/AdagenPI.pdf Macugen (pegaptanib) Bausch and Lomb http://www.bausch.com/Portals/69/-/m/BL/United%20States/USFiles/Package%20Inserts/Pharma/macugen-package-insert.pdf Critical Commercial
Techniques: Virus, Clinical Proteomics, Recombinant, Sequencing, Software, Control