apg-115 Search Results


apg 115  (MedChemExpress)
94
MedChemExpress apg 115
A , B WB assays assessing the expression levels of downstream proteins in A549 and H460 cells stably expressing shNC and shMAPK4. C , D WB assays assessing the expression levels of downstream proteins in A549 and H460 cells stably expressing PCDH and PCDH-MAPK4. E , F WB assays assessing the expression levels of downstream proteins in A549 and H460 cells stably expressing PCDH and PCDH-MAPK4 treated with or without PI3K inhibitor Alpelisib. G – J RT-Qpcr and WB assays validating the expression levels of MAPK4 in A549 and H460 treated with gradually increasing drug concentrations of p53-inducing <t>agent</t> <t>APG-115</t> for 24 h. Data in G and I are represented as mean ± SD, n = 3.
Apg 115, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/apg-115/Alrizomadlin/pmc12432164-31-5-17
Average 94 stars, based on 1 article reviews
apg 115 - by Bioz Stars, 2026-09
94/100 stars
  Buy from Supplier
apg 115  (Ascentage Pharma)
86
Ascentage Pharma apg 115
A , B WB assays assessing the expression levels of downstream proteins in A549 and H460 cells stably expressing shNC and shMAPK4. C , D WB assays assessing the expression levels of downstream proteins in A549 and H460 cells stably expressing PCDH and PCDH-MAPK4. E , F WB assays assessing the expression levels of downstream proteins in A549 and H460 cells stably expressing PCDH and PCDH-MAPK4 treated with or without PI3K inhibitor Alpelisib. G – J RT-Qpcr and WB assays validating the expression levels of MAPK4 in A549 and H460 treated with gradually increasing drug concentrations of p53-inducing <t>agent</t> <t>APG-115</t> for 24 h. Data in G and I are represented as mean ± SD, n = 3.
Apg 115, supplied by Ascentage Pharma, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/apg-115/115+apg/pmc09633396-762-9-14
Average 86 stars, based on 1 article reviews
apg 115 - by Bioz Stars, 2026-09
86/100 stars
  Buy from Supplier
apg 115  (Toronto Research Chemicals)
N/A
   Buy from Supplier
apg 115  (Biosynth Carbosynth)
N/A
   Buy from Supplier

Image Search Results


A , B WB assays assessing the expression levels of downstream proteins in A549 and H460 cells stably expressing shNC and shMAPK4. C , D WB assays assessing the expression levels of downstream proteins in A549 and H460 cells stably expressing PCDH and PCDH-MAPK4. E , F WB assays assessing the expression levels of downstream proteins in A549 and H460 cells stably expressing PCDH and PCDH-MAPK4 treated with or without PI3K inhibitor Alpelisib. G – J RT-Qpcr and WB assays validating the expression levels of MAPK4 in A549 and H460 treated with gradually increasing drug concentrations of p53-inducing agent APG-115 for 24 h. Data in G and I are represented as mean ± SD, n = 3.

Journal: Cell Death and Differentiation

Article Title: p53 transcriptionally activates DCP1B to suppress tumor progression and enhance tumor sensitivity to PI3K blockade in non-small cell lung cancer

doi: 10.1038/s41418-025-01501-y

Figure Lengend Snippet: A , B WB assays assessing the expression levels of downstream proteins in A549 and H460 cells stably expressing shNC and shMAPK4. C , D WB assays assessing the expression levels of downstream proteins in A549 and H460 cells stably expressing PCDH and PCDH-MAPK4. E , F WB assays assessing the expression levels of downstream proteins in A549 and H460 cells stably expressing PCDH and PCDH-MAPK4 treated with or without PI3K inhibitor Alpelisib. G – J RT-Qpcr and WB assays validating the expression levels of MAPK4 in A549 and H460 treated with gradually increasing drug concentrations of p53-inducing agent APG-115 for 24 h. Data in G and I are represented as mean ± SD, n = 3.

Article Snippet: Nutlin-3, 5-fluorouracil (5-Fu), Cisplatin, Etoposide, APG-115, Alpelisib, Actinomycin D (Act.D), and Dimethyl sulfoxide (DMSO) were purchased from MedChemExpress (MCE, Shanghai, China).

Techniques: Expressing, Stable Transfection, Quantitative RT-PCR

A – H Drug-sensitivity and the combination index (CI) of 2 drugs assays showing the synergistic inhibition effect of p53 agonist and PI3K inhibitor in A549 and H460 cells in vitro. Data in A , C , E and G are represented as mean ± SD, n = 3. I – M A549 cells were inoculated into BALB/c female nude mice. After 14 days of injection, mice were randomly divided into four groups including the control group, APG-115 group, Alpelisib group, and the co-drug group. After 3 weeks, mice were sacrificed and xenograft tumors were removed. Representative mice weight, tumor volume, tumor weight, and tumor images are shown. N The proposed working model. Data in K and L are represented as mean ± SD, n = 7.

Journal: Cell Death and Differentiation

Article Title: p53 transcriptionally activates DCP1B to suppress tumor progression and enhance tumor sensitivity to PI3K blockade in non-small cell lung cancer

doi: 10.1038/s41418-025-01501-y

Figure Lengend Snippet: A – H Drug-sensitivity and the combination index (CI) of 2 drugs assays showing the synergistic inhibition effect of p53 agonist and PI3K inhibitor in A549 and H460 cells in vitro. Data in A , C , E and G are represented as mean ± SD, n = 3. I – M A549 cells were inoculated into BALB/c female nude mice. After 14 days of injection, mice were randomly divided into four groups including the control group, APG-115 group, Alpelisib group, and the co-drug group. After 3 weeks, mice were sacrificed and xenograft tumors were removed. Representative mice weight, tumor volume, tumor weight, and tumor images are shown. N The proposed working model. Data in K and L are represented as mean ± SD, n = 7.

Article Snippet: Nutlin-3, 5-fluorouracil (5-Fu), Cisplatin, Etoposide, APG-115, Alpelisib, Actinomycin D (Act.D), and Dimethyl sulfoxide (DMSO) were purchased from MedChemExpress (MCE, Shanghai, China).

Techniques: Inhibition, In Vitro, Injection, Control