anti fkbp51 Search Results


hi51b  (StressMarq)
90
StressMarq hi51b
Hi51b, supplied by StressMarq, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/hi51b/product/StressMarq
Average 90 stars, based on 1 article reviews
hi51b - by Bioz Stars, 2026-03
90/100 stars
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alphalisa anti-fkbp51 mab  (Abnova)
90
Abnova alphalisa anti-fkbp51 mab
A) In a co-factor recruitment assay, Org 214007-0, in comparison to prednisolone, shows potent but partial recruitment of a 0.1 μM peptide presenting TIF2 -3. On the Y-axis average fluorescence counts (+/− SD) are shown. EC50 values (%CV) and percentages maximal efficacy (%CV) for Org 214007-0 versus prednisolone were 10 (7.4) nM versus 48 (3.2) nM and 67 (7.1) % vs 100% respectively. B) In THP1 cells Org 214007-0 shows partial induction of <t>FKBP51</t> protein expression and C) under inflammatory conditions represses the IL-6 protein expression almost as good as prednisolone does.
Alphalisa Anti Fkbp51 Mab, supplied by Abnova, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/alphalisa anti-fkbp51 mab/product/Abnova
Average 90 stars, based on 1 article reviews
alphalisa anti-fkbp51 mab - by Bioz Stars, 2026-03
90/100 stars
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anti-fkbp51 antibody  (Cocalico Inc)
90
Cocalico Inc anti-fkbp51 antibody
A) In a co-factor recruitment assay, Org 214007-0, in comparison to prednisolone, shows potent but partial recruitment of a 0.1 μM peptide presenting TIF2 -3. On the Y-axis average fluorescence counts (+/− SD) are shown. EC50 values (%CV) and percentages maximal efficacy (%CV) for Org 214007-0 versus prednisolone were 10 (7.4) nM versus 48 (3.2) nM and 67 (7.1) % vs 100% respectively. B) In THP1 cells Org 214007-0 shows partial induction of <t>FKBP51</t> protein expression and C) under inflammatory conditions represses the IL-6 protein expression almost as good as prednisolone does.
Anti Fkbp51 Antibody, supplied by Cocalico Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/anti-fkbp51 antibody/product/Cocalico Inc
Average 90 stars, based on 1 article reviews
anti-fkbp51 antibody - by Bioz Stars, 2026-03
90/100 stars
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anti-fkbp51  (Becton Dickinson)
90
Becton Dickinson anti-fkbp51
A) In a co-factor recruitment assay, Org 214007-0, in comparison to prednisolone, shows potent but partial recruitment of a 0.1 μM peptide presenting TIF2 -3. On the Y-axis average fluorescence counts (+/− SD) are shown. EC50 values (%CV) and percentages maximal efficacy (%CV) for Org 214007-0 versus prednisolone were 10 (7.4) nM versus 48 (3.2) nM and 67 (7.1) % vs 100% respectively. B) In THP1 cells Org 214007-0 shows partial induction of <t>FKBP51</t> protein expression and C) under inflammatory conditions represses the IL-6 protein expression almost as good as prednisolone does.
Anti Fkbp51, supplied by Becton Dickinson, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/anti-fkbp51/product/Becton Dickinson
Average 90 stars, based on 1 article reviews
anti-fkbp51 - by Bioz Stars, 2026-03
90/100 stars
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rabbit anti-fkbp51 gtx66429  (GeneTex)
90
GeneTex rabbit anti-fkbp51 gtx66429
A) In a co-factor recruitment assay, Org 214007-0, in comparison to prednisolone, shows potent but partial recruitment of a 0.1 μM peptide presenting TIF2 -3. On the Y-axis average fluorescence counts (+/− SD) are shown. EC50 values (%CV) and percentages maximal efficacy (%CV) for Org 214007-0 versus prednisolone were 10 (7.4) nM versus 48 (3.2) nM and 67 (7.1) % vs 100% respectively. B) In THP1 cells Org 214007-0 shows partial induction of <t>FKBP51</t> protein expression and C) under inflammatory conditions represses the IL-6 protein expression almost as good as prednisolone does.
Rabbit Anti Fkbp51 Gtx66429, supplied by GeneTex, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rabbit anti-fkbp51 gtx66429/product/GeneTex
Average 90 stars, based on 1 article reviews
rabbit anti-fkbp51 gtx66429 - by Bioz Stars, 2026-03
90/100 stars
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anti-fkbp51 (pa1-20  (Biozol Diagnostica Vertrieb GmbH)
90
Biozol Diagnostica Vertrieb GmbH anti-fkbp51 (pa1-20
A) In a co-factor recruitment assay, Org 214007-0, in comparison to prednisolone, shows potent but partial recruitment of a 0.1 μM peptide presenting TIF2 -3. On the Y-axis average fluorescence counts (+/− SD) are shown. EC50 values (%CV) and percentages maximal efficacy (%CV) for Org 214007-0 versus prednisolone were 10 (7.4) nM versus 48 (3.2) nM and 67 (7.1) % vs 100% respectively. B) In THP1 cells Org 214007-0 shows partial induction of <t>FKBP51</t> protein expression and C) under inflammatory conditions represses the IL-6 protein expression almost as good as prednisolone does.
Anti Fkbp51 (Pa1 20, supplied by Biozol Diagnostica Vertrieb GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/anti-fkbp51 (pa1-20/product/Biozol Diagnostica Vertrieb GmbH
Average 90 stars, based on 1 article reviews
anti-fkbp51 (pa1-20 - by Bioz Stars, 2026-03
90/100 stars
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Image Search Results


A) In a co-factor recruitment assay, Org 214007-0, in comparison to prednisolone, shows potent but partial recruitment of a 0.1 μM peptide presenting TIF2 -3. On the Y-axis average fluorescence counts (+/− SD) are shown. EC50 values (%CV) and percentages maximal efficacy (%CV) for Org 214007-0 versus prednisolone were 10 (7.4) nM versus 48 (3.2) nM and 67 (7.1) % vs 100% respectively. B) In THP1 cells Org 214007-0 shows partial induction of FKBP51 protein expression and C) under inflammatory conditions represses the IL-6 protein expression almost as good as prednisolone does.

Journal: PLoS ONE

Article Title: Org 214007-0: A Novel Non-Steroidal Selective Glucocorticoid Receptor Modulator with Full Anti-Inflammatory Properties and Improved Therapeutic Index

doi: 10.1371/journal.pone.0048385

Figure Lengend Snippet: A) In a co-factor recruitment assay, Org 214007-0, in comparison to prednisolone, shows potent but partial recruitment of a 0.1 μM peptide presenting TIF2 -3. On the Y-axis average fluorescence counts (+/− SD) are shown. EC50 values (%CV) and percentages maximal efficacy (%CV) for Org 214007-0 versus prednisolone were 10 (7.4) nM versus 48 (3.2) nM and 67 (7.1) % vs 100% respectively. B) In THP1 cells Org 214007-0 shows partial induction of FKBP51 protein expression and C) under inflammatory conditions represses the IL-6 protein expression almost as good as prednisolone does.

Article Snippet: For the FKBP51-specific AlphaLISA anti-FKBP51 Mab (Abnova, Cat H0002289-M01) and Goat anti-IgG FKBP51 polyclonal (Santa Cruz Biotechnology, Cat sc-11514) were used and the same procedure was followed as for the cytokine-specific AlphaLISAs (more detailed information in Supportive Information) (SI text).

Techniques: Comparison, Fluorescence, Expressing

Fold changes for the top 25 genes either induced (A) or repressed (B) by 1 μM prednisolone and 1 μM Org 214007-0 in THP-1 cells. NB. Scales are in 2log. Example of an induced gene, FK506 binding protein 51 (FKBP51) (C) and a repressed gene, interleukin 6 (IL-6) (D) in comparison to the vehicle control under either non-stimulated or stimulated (IFNγ/TNFα) condition. Fold changes for the top 25 genes either induced (E) or repressed (F) by 1.5 mg/kg prednisolone and 0.3 mg/kg Org 214007-0 in muscle tissue from arthritic mice. NB. Scales are in 2log. Example of an induced gene (Per-2) (G) and a repressed gene (Ccl8) (H) in comparison to vehicle treated arthritic mice and vehicle treated healthy mice.

Journal: PLoS ONE

Article Title: Org 214007-0: A Novel Non-Steroidal Selective Glucocorticoid Receptor Modulator with Full Anti-Inflammatory Properties and Improved Therapeutic Index

doi: 10.1371/journal.pone.0048385

Figure Lengend Snippet: Fold changes for the top 25 genes either induced (A) or repressed (B) by 1 μM prednisolone and 1 μM Org 214007-0 in THP-1 cells. NB. Scales are in 2log. Example of an induced gene, FK506 binding protein 51 (FKBP51) (C) and a repressed gene, interleukin 6 (IL-6) (D) in comparison to the vehicle control under either non-stimulated or stimulated (IFNγ/TNFα) condition. Fold changes for the top 25 genes either induced (E) or repressed (F) by 1.5 mg/kg prednisolone and 0.3 mg/kg Org 214007-0 in muscle tissue from arthritic mice. NB. Scales are in 2log. Example of an induced gene (Per-2) (G) and a repressed gene (Ccl8) (H) in comparison to vehicle treated arthritic mice and vehicle treated healthy mice.

Article Snippet: For the FKBP51-specific AlphaLISA anti-FKBP51 Mab (Abnova, Cat H0002289-M01) and Goat anti-IgG FKBP51 polyclonal (Santa Cruz Biotechnology, Cat sc-11514) were used and the same procedure was followed as for the cytokine-specific AlphaLISAs (more detailed information in Supportive Information) (SI text).

Techniques: Binding Assay, Comparison, Control

Summary of studies to define the therapeutic index (TI) of Org 214007-0.

Journal: PLoS ONE

Article Title: Org 214007-0: A Novel Non-Steroidal Selective Glucocorticoid Receptor Modulator with Full Anti-Inflammatory Properties and Improved Therapeutic Index

doi: 10.1371/journal.pone.0048385

Figure Lengend Snippet: Summary of studies to define the therapeutic index (TI) of Org 214007-0.

Article Snippet: For the FKBP51-specific AlphaLISA anti-FKBP51 Mab (Abnova, Cat H0002289-M01) and Goat anti-IgG FKBP51 polyclonal (Santa Cruz Biotechnology, Cat sc-11514) were used and the same procedure was followed as for the cytokine-specific AlphaLISAs (more detailed information in Supportive Information) (SI text).

Techniques:

A) Ratio of the read count for clusters induced by 1 μM prednisolone or 1 μM Org 214007-0 in a ChIP-Seq analysis. If Org 214007-0 and prednisolone would induce an equal number of reads, the histogram would be centered on Log0, indicated by the dotted line. There is a clear shift to the right from this line (P-value (mean = 0) <0.000001), indicating that prednisolone leads to more GR occupancy than Org 214007-0. B) Example profile of the tag clusters in the GR response gene FKBP51. Multiple binding sites are found within this gene, each showing denser clusters after treatment with 1 μM prednisolone than after treatment with 1 μM Org 214007-0. The inset highlights an intronic region at 87 kb downstream of the transcription start site. This region that was identified by Paakinaho et al. (2010) , as a major intronic enhancer in human A459 lung cancer cells and was shown to be occupied by GR after treatment with the GR ligand dexamethasone.

Journal: PLoS ONE

Article Title: Org 214007-0: A Novel Non-Steroidal Selective Glucocorticoid Receptor Modulator with Full Anti-Inflammatory Properties and Improved Therapeutic Index

doi: 10.1371/journal.pone.0048385

Figure Lengend Snippet: A) Ratio of the read count for clusters induced by 1 μM prednisolone or 1 μM Org 214007-0 in a ChIP-Seq analysis. If Org 214007-0 and prednisolone would induce an equal number of reads, the histogram would be centered on Log0, indicated by the dotted line. There is a clear shift to the right from this line (P-value (mean = 0) <0.000001), indicating that prednisolone leads to more GR occupancy than Org 214007-0. B) Example profile of the tag clusters in the GR response gene FKBP51. Multiple binding sites are found within this gene, each showing denser clusters after treatment with 1 μM prednisolone than after treatment with 1 μM Org 214007-0. The inset highlights an intronic region at 87 kb downstream of the transcription start site. This region that was identified by Paakinaho et al. (2010) , as a major intronic enhancer in human A459 lung cancer cells and was shown to be occupied by GR after treatment with the GR ligand dexamethasone.

Article Snippet: For the FKBP51-specific AlphaLISA anti-FKBP51 Mab (Abnova, Cat H0002289-M01) and Goat anti-IgG FKBP51 polyclonal (Santa Cruz Biotechnology, Cat sc-11514) were used and the same procedure was followed as for the cytokine-specific AlphaLISAs (more detailed information in Supportive Information) (SI text).

Techniques: ChIP-sequencing, Binding Assay