Journal: International Journal of Pharmacokinetics

Article Title: Method development challenges and regulatory expectation in nifedipine

doi: 10.4155/ipk-2016-0004

Figure Lengend Snippet: Figure 3. Matrix effect: postcolumn infusion (T-Joint) method for nifedipine and nifedipine–d4 (RT 2.88) to demonstrate absence of any ion suppression/enhancement.

Article Snippet: Dehydro nifedipine (purity: 98%) and hydroxydehydro nifedipine carboxylate (purity: 97%) were procured from Toronto Research Chemicals (Ontario, Canada).

Techniques:

Journal: Computers in Biology and Medicine

Article Title: Identification of FDA approved drugs and nucleoside analogues as potential SARS-CoV-2 A1pp domain inhibitor: An in silico study

doi: 10.1016/j.compbiomed.2020.104185

Figure Lengend Snippet: Surface structure of lead FDA approved drug, nucleoside inhibitor and natural substrate at SARS-CoV-2 A1pp domain active site. (A) Surface structure of lactobionic acid at ADP-ribose-1″-phosphatase active site. (B) Surface structure of NA 1 at ADP-ribose-1″-phosphatase active site. (C) Surface structure of adenosine-5-diphosphoribose at ADP-ribose-1″-phosphatase active site. (D) 2D structure of lactobionic acid. (E) 2D structure of NA 1 . (F) 2D structure of adenosine-5-diphosphoribose.

Article Snippet: The structures of FDA approved drugs and nucleoside analogues were downloaded from selleckchem ( https://www.selleckchem.com/ ) in. sdf format and converted to different formats using Open Babel software.

Techniques:

Journal: bioRxiv

Article Title: CRISPRa screen identifies a role for c-KIT signaling in tamoxifen resistance, potentially through upregulation of ABC transporters

doi: 10.1101/2022.08.22.504845

Figure Lengend Snippet: A) The percentage of inhibition of MCF-7-S cells treated with increasing concentrations of TAM and Gleevec. The shade of red represents the amount of inhibition in cells. B) Observed synergism scores that correspond to the percent inhibition values of TAM and Gleevec treatment using ZIP synergy from SynergyFinder 2.0.

Article Snippet: The following cell culture media supplements and concentrations were used throughout this study unless indicated otherwise: Doxycycline hyclate (2ug/ml, Sigma, cat# D9891-5G), tamoxifen as (Z)-4-Hydroxytamoxifen (1uM, 4-OHT; Sigma-Aldrich; Cat# H7904), and Gleevec (Imatinib mesylate; Santa Cruz; cat # CAS 220127-57-1).

Techniques: Inhibition