Journal: Cell and Tissue Banking

Article Title: The promising approach of MSCs therapy for COVID-19 treatment

doi: 10.1007/s10561-022-10060-2

Figure Lengend Snippet: Summarized clinical trial (marked “completed”) studies on the MSCs in the COVID-19 ( https://www.clinicaltrials.gov )

Article Snippet: NCT04522986 , An exploratory study of ADR-001 in patients with severe pneumonia caused by SARS-CoV-2 infection , Rohto Pharmaceutical Co., Ltd./ Japan , 6 , MSC 1 × 10 ^ 8 cells were administered once a week, total four times intravenously. , I , Patients with Severe Pneumonia caused by SARS-CoV-2 infection were enrolled to the study. adMSCs were administered once a week, total four times intravenously. Safety and efficacy of adMSCs were evaluated for 12 weeks after first administer..

Techniques: Injection, Marker, Real-time Polymerase Chain Reaction, Transplantation Assay, Infection, Saline, Modification, Ex Vivo, Derivative Assay, Clinical Proteomics, Control, Virus, Flow Cytometry

Journal: Intervirology

Article Title: Features of Pathobiology and Clinical Translation of Approved Treatments for Coronavirus Disease 2019

doi: 10.1159/000520234

Figure Lengend Snippet: Drug options, which can be a candidate to treat COVID-19

Article Snippet: Cell-based therapy , AdMSCs , Celltex Therapeutics Corporation , Phase 2 (NCT04428801) , Each subject receives 3 doses of 200 million autologous adipose-derived mesenchymal stem cells via intravenous infusion every 3 days , May reduce the acute lung injury and inhibit the cell-mediated inflammatory response induced by SARS-CoV-2 , Uncommon Multiply or change into inappropriate cell types, tumor genesis, infection, and thrombus formation.

Techniques: Membrane, Bioprocessing, Blocking Assay, Recombinant, Clinical Proteomics, Virus, Infection, Chemotaxis Assay, Expressing, Activity Assay, Injection

Journal: ACS nano

Article Title: Inducing Stem Cell Myogenesis Using NanoScript

doi: 10.1021/acsnano.5b00709

Figure Lengend Snippet: NanoScript-MRF initiates transcription and activation of myogenic genes. (a) After 7 days post-treatment with NanoScript-MRF, qPCR analysis reveals overexpression of targeted MRFs as well as significant expression of the late-stage myogenic gene MYH1by NanoScript-MRF (red) as compared to the untreated control (gray). (b) Multipotent genes of ADMSCs were down-regulated as compared to untreated control cells, thus indicating that stem properties of ADMSCs are repressed when myogenic genes are overexpressed. Error bars are from three independent trials, and mRNA expression is represented as a fold change compared to the control.

Article Snippet: ADMSC Culture and Myogenic Differentiation The human ADMSCs (American CryoStem) and the 0.5% fetal bovine serum growth media were provided by American CryoStem.

Techniques: Activation Assay, Over Expression, Expressing, Control