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Image Search Results
Journal: The Journal of Neuroscience
Article Title: Arginine Methyltransferase 1 in the Nucleus Accumbens Regulates Behavioral Effects of Cocaine
doi: 10.1523/JNEUROSCI.0246-15.2015
Figure Lengend Snippet: SKLB-639 attenuates cocaine reward via specifically inhibiting modification of H4R3me2a in vivo. A, Timeline of the cocaine CPP experiment. B, Intra-NAc SKLB-639 (1 mm, 1 μl/injection) significantly attenuated cocaine CPP. *p < 0.05, ***p < 0.001. n.s., Not significant. n = 13 Vehicle+Saline, n = 10 SKLB-639+Saline, n = 11 Vehicle+Cocaine, n = 13 SKLB-639+Cocaine. C, SKLB-639 decreased expression of H4R3me2a in NAc. *p < 0.05, **p < 0.01. n.s., Not significant. n = 4 Vehicle+Saline, n = 4 Vehicle+Cocaine, n = 4 SKLB-639+Cocaine, n = 4 SKLB-639+Saline. D–F, SKLB-639 did not influence levels of H3R2me2a, H3R17me2a, and dimethyl (sym) in NAc in vivo, respectively. n = 4 Vehicle+Saline, n = 4 SKLB-639+Saline, n = 4 Vehicle+Cocaine, n = 4 SKLB-639+Cocaine. Data are presented as the mean ± SEM.
Article Snippet: The expression levels of PRMT1 (catalog #ab70724, abcam), PRMT4 (catalog #4438, CST), PRMT5 (catalog #2252, CST), H4R3me2a (catalog #39705, Active motif), H3R17me2a (catalog #A2421, ABclonal Technology),
Techniques: Modification, In Vivo, Injection, Saline, Expressing