a08632 Search Results


aguaruna jivaro women  (Boster Bio)
93
Boster Bio aguaruna jivaro women
Aguaruna Jivaro Women, supplied by Boster Bio, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/aguaruna jivaro women/product/Boster Bio
Average 93 stars, based on 1 article reviews
aguaruna jivaro women - by Bioz Stars, 2026-03
93/100 stars
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p2x7 receptor antagonist a740003  (Millipore)
90
Millipore p2x7 receptor antagonist a740003
Astrocytes mediated the electroacupuncture-induced downregulation of the NMDA and <t>P2X7</t> receptors in the spinal dorsal horn of rats with visceral pain. A Schematic of intrathecal injection of FCA affects the excitability of dorsal horn glutamatergic neuron by inhibiting the activity of astrocytes. B 30 min after intrathecal injection of FCA, EA was performed for 7 consecutive days (0.1 mm, 10 μL) significantly reducing visceral hypersensitivity but FCA did not synergize with EA to achieve a better analgesic effect. FCA failed to synergize with EA to achieve a better analgesic effect (P > 0.05, FCA + EA vs EA). C and D The effect of FCA and EA on NR1 expression and its mRNA leve. E and F the effect of FCA and EA on NR2B expression and its mRNA. Spinal cord astrocytes mediated the inhibitory effect of EA on spinal cord sensitization in VH rats. G and H P2X7 had a sensitizing effect in the spinal cord sensitization of visceral pain and may be involved in the EA-induced inhibition of spinal sensitization. vs Con, ▲P < 0.05, ▲▲P < 0.01, vs VH, *P < 0.05, **P < 0.01
P2x7 Receptor Antagonist A740003, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/p2x7 receptor antagonist a740003/product/Millipore
Average 90 stars, based on 1 article reviews
p2x7 receptor antagonist a740003 - by Bioz Stars, 2026-03
90/100 stars
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atto-594  (Millipore)
90
Millipore atto-594
Astrocytes mediated the electroacupuncture-induced downregulation of the NMDA and <t>P2X7</t> receptors in the spinal dorsal horn of rats with visceral pain. A Schematic of intrathecal injection of FCA affects the excitability of dorsal horn glutamatergic neuron by inhibiting the activity of astrocytes. B 30 min after intrathecal injection of FCA, EA was performed for 7 consecutive days (0.1 mm, 10 μL) significantly reducing visceral hypersensitivity but FCA did not synergize with EA to achieve a better analgesic effect. FCA failed to synergize with EA to achieve a better analgesic effect (P > 0.05, FCA + EA vs EA). C and D The effect of FCA and EA on NR1 expression and its mRNA leve. E and F the effect of FCA and EA on NR2B expression and its mRNA. Spinal cord astrocytes mediated the inhibitory effect of EA on spinal cord sensitization in VH rats. G and H P2X7 had a sensitizing effect in the spinal cord sensitization of visceral pain and may be involved in the EA-induced inhibition of spinal sensitization. vs Con, ▲P < 0.05, ▲▲P < 0.01, vs VH, *P < 0.05, **P < 0.01
Atto 594, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/atto-594/product/Millipore
Average 90 stars, based on 1 article reviews
atto-594 - by Bioz Stars, 2026-03
90/100 stars
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a08632 boster mad2 antibody  (Boster Bio)
93
Boster Bio a08632 boster mad2 antibody
Astrocytes mediated the electroacupuncture-induced downregulation of the NMDA and <t>P2X7</t> receptors in the spinal dorsal horn of rats with visceral pain. A Schematic of intrathecal injection of FCA affects the excitability of dorsal horn glutamatergic neuron by inhibiting the activity of astrocytes. B 30 min after intrathecal injection of FCA, EA was performed for 7 consecutive days (0.1 mm, 10 μL) significantly reducing visceral hypersensitivity but FCA did not synergize with EA to achieve a better analgesic effect. FCA failed to synergize with EA to achieve a better analgesic effect (P > 0.05, FCA + EA vs EA). C and D The effect of FCA and EA on NR1 expression and its mRNA leve. E and F the effect of FCA and EA on NR2B expression and its mRNA. Spinal cord astrocytes mediated the inhibitory effect of EA on spinal cord sensitization in VH rats. G and H P2X7 had a sensitizing effect in the spinal cord sensitization of visceral pain and may be involved in the EA-induced inhibition of spinal sensitization. vs Con, ▲P < 0.05, ▲▲P < 0.01, vs VH, *P < 0.05, **P < 0.01
A08632 Boster Mad2 Antibody, supplied by Boster Bio, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/a08632 boster mad2 antibody/product/Boster Bio
Average 93 stars, based on 1 article reviews
a08632 boster mad2 antibody - by Bioz Stars, 2026-03
93/100 stars
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a740003  (Merck & Co)
90
Merck & Co a740003
Astrocytes mediated the electroacupuncture-induced downregulation of the NMDA and <t>P2X7</t> receptors in the spinal dorsal horn of rats with visceral pain. A Schematic of intrathecal injection of FCA affects the excitability of dorsal horn glutamatergic neuron by inhibiting the activity of astrocytes. B 30 min after intrathecal injection of FCA, EA was performed for 7 consecutive days (0.1 mm, 10 μL) significantly reducing visceral hypersensitivity but FCA did not synergize with EA to achieve a better analgesic effect. FCA failed to synergize with EA to achieve a better analgesic effect (P > 0.05, FCA + EA vs EA). C and D The effect of FCA and EA on NR1 expression and its mRNA leve. E and F the effect of FCA and EA on NR2B expression and its mRNA. Spinal cord astrocytes mediated the inhibitory effect of EA on spinal cord sensitization in VH rats. G and H P2X7 had a sensitizing effect in the spinal cord sensitization of visceral pain and may be involved in the EA-induced inhibition of spinal sensitization. vs Con, ▲P < 0.05, ▲▲P < 0.01, vs VH, *P < 0.05, **P < 0.01
A740003, supplied by Merck & Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/a740003/product/Merck & Co
Average 90 stars, based on 1 article reviews
a740003 - by Bioz Stars, 2026-03
90/100 stars
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a740003  (Millipore)
90
Millipore a740003
Astrocytes mediated the electroacupuncture-induced downregulation of the NMDA and <t>P2X7</t> receptors in the spinal dorsal horn of rats with visceral pain. A Schematic of intrathecal injection of FCA affects the excitability of dorsal horn glutamatergic neuron by inhibiting the activity of astrocytes. B 30 min after intrathecal injection of FCA, EA was performed for 7 consecutive days (0.1 mm, 10 μL) significantly reducing visceral hypersensitivity but FCA did not synergize with EA to achieve a better analgesic effect. FCA failed to synergize with EA to achieve a better analgesic effect (P > 0.05, FCA + EA vs EA). C and D The effect of FCA and EA on NR1 expression and its mRNA leve. E and F the effect of FCA and EA on NR2B expression and its mRNA. Spinal cord astrocytes mediated the inhibitory effect of EA on spinal cord sensitization in VH rats. G and H P2X7 had a sensitizing effect in the spinal cord sensitization of visceral pain and may be involved in the EA-induced inhibition of spinal sensitization. vs Con, ▲P < 0.05, ▲▲P < 0.01, vs VH, *P < 0.05, **P < 0.01
A740003, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/a740003/product/Millipore
Average 90 stars, based on 1 article reviews
a740003 - by Bioz Stars, 2026-03
90/100 stars
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(2-ethoxy-5-methoxyphenyl)acetic acid  (Biosynth Carbosynth)
N/A
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2,4-dimethyl-1-[(oxiran-2-yl)methyl]piperazine  (Biosynth Carbosynth)
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2-(2-bromoethyl)naphthalene  (Biosynth Carbosynth)
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3'-azido-n6-benzoyl-5'-o-benzoyl-2',3'-dideoxyadenosine  (Biosynth Carbosynth)
N/A
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3-fluoro-9h-thioxanthen-9-one  (Biosynth Carbosynth)
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anti-scamp1 antibody  (Boster Bio)
N/A
Boster Bio Anti-SCAMP1 Antibody (Catalog# A08692). Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat.
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Image Search Results


Astrocytes mediated the electroacupuncture-induced downregulation of the NMDA and P2X7 receptors in the spinal dorsal horn of rats with visceral pain. A Schematic of intrathecal injection of FCA affects the excitability of dorsal horn glutamatergic neuron by inhibiting the activity of astrocytes. B 30 min after intrathecal injection of FCA, EA was performed for 7 consecutive days (0.1 mm, 10 μL) significantly reducing visceral hypersensitivity but FCA did not synergize with EA to achieve a better analgesic effect. FCA failed to synergize with EA to achieve a better analgesic effect (P > 0.05, FCA + EA vs EA). C and D The effect of FCA and EA on NR1 expression and its mRNA leve. E and F the effect of FCA and EA on NR2B expression and its mRNA. Spinal cord astrocytes mediated the inhibitory effect of EA on spinal cord sensitization in VH rats. G and H P2X7 had a sensitizing effect in the spinal cord sensitization of visceral pain and may be involved in the EA-induced inhibition of spinal sensitization. vs Con, ▲P < 0.05, ▲▲P < 0.01, vs VH, *P < 0.05, **P < 0.01

Journal: Purinergic Signalling

Article Title: Spinal cord astrocyte P2X7Rs mediate the inhibitory effect of electroacupuncture on visceral hypersensitivity of rat with irritable bowel syndrome

doi: 10.1007/s11302-021-09830-6

Figure Lengend Snippet: Astrocytes mediated the electroacupuncture-induced downregulation of the NMDA and P2X7 receptors in the spinal dorsal horn of rats with visceral pain. A Schematic of intrathecal injection of FCA affects the excitability of dorsal horn glutamatergic neuron by inhibiting the activity of astrocytes. B 30 min after intrathecal injection of FCA, EA was performed for 7 consecutive days (0.1 mm, 10 μL) significantly reducing visceral hypersensitivity but FCA did not synergize with EA to achieve a better analgesic effect. FCA failed to synergize with EA to achieve a better analgesic effect (P > 0.05, FCA + EA vs EA). C and D The effect of FCA and EA on NR1 expression and its mRNA leve. E and F the effect of FCA and EA on NR2B expression and its mRNA. Spinal cord astrocytes mediated the inhibitory effect of EA on spinal cord sensitization in VH rats. G and H P2X7 had a sensitizing effect in the spinal cord sensitization of visceral pain and may be involved in the EA-induced inhibition of spinal sensitization. vs Con, ▲P < 0.05, ▲▲P < 0.01, vs VH, *P < 0.05, **P < 0.01

Article Snippet: The drug doses were as follows: fluorocitrate (FCA) (0.1 mM, 10 μL) (F9634-100MG, Sigma), P2X7 receptor antagonist A740003 (250 nM, 10 μL) (A0862-5MG, Sigma), and P2X7 receptor agonist BzATP (30 μM, 10 μL) (B6396-5MG, Sigma) [ 4 ].

Techniques: Injection, Activity Assay, Expressing, Inhibition

Inhibitory effect of EA on spinal cord sensitization mediated by the P2X7 receptor. A P2X7 receptor affects neuronal excitability of spinal cord by regulating the release of inflammatory cytokines by astrocytes. B 30 min after intrathecal injection of P2X7 receptor antagonist A740003 (250 nM, 10 μL) and agonist BzATP (30 μm, 10 μL), EA was performed for 7 consecutive days. Both EA and A740003 could reduce the AWR scores and BzATP could reverse the analgesic effect of EA. C Immunofluorescence staining of GFAP (the biomarker of activity of astrocytes in spinal dorsal horn). Con represents the normal control group, VH represents the visceral hyperalgesia group, and EA represents the electroacupuncture group, bar = 100 μm. D The roles of A740003 and BzATP in the EA-induced inhibition of GFAP expression in astrocytes. The P2X7 receptor mediated the inhibitory effect of EA on the activity of astrocytes. E and F The roles of A740003 and BzATP in the EA-induced inhibition of the expression of NR1 and NR2B subunits in the spinal cord. The P2X7 receptor is involved in the regulation of EA on the expression of NMDA-NR1 and NMDA-NR2B subunits in the spinal cord. VH vs Con ▲P < 0.05, ▲▲P < 0.01. A74003 + EA or EA vs VH, *P < 0.05, **P < 0.01. BzATP + EA vs EA, #P < 0.05, ##P < 0.01

Journal: Purinergic Signalling

Article Title: Spinal cord astrocyte P2X7Rs mediate the inhibitory effect of electroacupuncture on visceral hypersensitivity of rat with irritable bowel syndrome

doi: 10.1007/s11302-021-09830-6

Figure Lengend Snippet: Inhibitory effect of EA on spinal cord sensitization mediated by the P2X7 receptor. A P2X7 receptor affects neuronal excitability of spinal cord by regulating the release of inflammatory cytokines by astrocytes. B 30 min after intrathecal injection of P2X7 receptor antagonist A740003 (250 nM, 10 μL) and agonist BzATP (30 μm, 10 μL), EA was performed for 7 consecutive days. Both EA and A740003 could reduce the AWR scores and BzATP could reverse the analgesic effect of EA. C Immunofluorescence staining of GFAP (the biomarker of activity of astrocytes in spinal dorsal horn). Con represents the normal control group, VH represents the visceral hyperalgesia group, and EA represents the electroacupuncture group, bar = 100 μm. D The roles of A740003 and BzATP in the EA-induced inhibition of GFAP expression in astrocytes. The P2X7 receptor mediated the inhibitory effect of EA on the activity of astrocytes. E and F The roles of A740003 and BzATP in the EA-induced inhibition of the expression of NR1 and NR2B subunits in the spinal cord. The P2X7 receptor is involved in the regulation of EA on the expression of NMDA-NR1 and NMDA-NR2B subunits in the spinal cord. VH vs Con ▲P < 0.05, ▲▲P < 0.01. A74003 + EA or EA vs VH, *P < 0.05, **P < 0.01. BzATP + EA vs EA, #P < 0.05, ##P < 0.01

Article Snippet: The drug doses were as follows: fluorocitrate (FCA) (0.1 mM, 10 μL) (F9634-100MG, Sigma), P2X7 receptor antagonist A740003 (250 nM, 10 μL) (A0862-5MG, Sigma), and P2X7 receptor agonist BzATP (30 μM, 10 μL) (B6396-5MG, Sigma) [ 4 ].

Techniques: Injection, Immunofluorescence, Staining, Biomarker Assay, Activity Assay, Inhibition, Expressing