HY-P990377 Search Results


nipocalimab m281  (MedChemExpress)
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MedChemExpress nipocalimab m281
Inhibition of endocytotic albumin and IgG uptake by the FcRn-blocking antibody <t>nipocalimab.</t> ASCs remained untreated or were preincubated for 2 h with different doses of nipocalimab (5, 15, 25 μg/mL), and the intracellular content of either Alexa-594 albumin ( n = 6) ( a ) or IgG ( n = 6) ( b ) was monitored after 1 h of incubation. Intracellular IgG was visualized by labeling with an anti IgG antibody conjugated with Alexa Fluor 488. Scale bars represent 10 μm. * , ** , *** p < 0.05, 0.01, 0.001 as compared to the untreated sample. c , d Inhibition of Ca 2+ oscillations by nipocalimab (25 μg/mL). c Untreated ASCs in serum-containing complete ASC cell culture medium. d Nipocalimab-treated sample. Shown are representative traces derived from n = 12 experiments.
Nipocalimab M281, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Inhibition of endocytotic albumin and IgG uptake by the FcRn-blocking antibody nipocalimab. ASCs remained untreated or were preincubated for 2 h with different doses of nipocalimab (5, 15, 25 μg/mL), and the intracellular content of either Alexa-594 albumin ( n = 6) ( a ) or IgG ( n = 6) ( b ) was monitored after 1 h of incubation. Intracellular IgG was visualized by labeling with an anti IgG antibody conjugated with Alexa Fluor 488. Scale bars represent 10 μm. * , ** , *** p < 0.05, 0.01, 0.001 as compared to the untreated sample. c , d Inhibition of Ca 2+ oscillations by nipocalimab (25 μg/mL). c Untreated ASCs in serum-containing complete ASC cell culture medium. d Nipocalimab-treated sample. Shown are representative traces derived from n = 12 experiments.

Journal: Cells, Tissues, Organs

Article Title: Endocytotic Albumin Uptake Pathways in Human Adipose Stem Cells and Connection to Intracellular Calcium Oscillations and the Neonatal Fc receptor

doi: 10.1159/000545773

Figure Lengend Snippet: Inhibition of endocytotic albumin and IgG uptake by the FcRn-blocking antibody nipocalimab. ASCs remained untreated or were preincubated for 2 h with different doses of nipocalimab (5, 15, 25 μg/mL), and the intracellular content of either Alexa-594 albumin ( n = 6) ( a ) or IgG ( n = 6) ( b ) was monitored after 1 h of incubation. Intracellular IgG was visualized by labeling with an anti IgG antibody conjugated with Alexa Fluor 488. Scale bars represent 10 μm. * , ** , *** p < 0.05, 0.01, 0.001 as compared to the untreated sample. c , d Inhibition of Ca 2+ oscillations by nipocalimab (25 μg/mL). c Untreated ASCs in serum-containing complete ASC cell culture medium. d Nipocalimab-treated sample. Shown are representative traces derived from n = 12 experiments.

Article Snippet: Subconfluent live ASCs were incubated with nipocalimab (M281) (MedChemExpress, cat. No. HY-P99037) at concentrations of 5, 15 and 25 μg/mL.

Techniques: Inhibition, Blocking Assay, Incubation, Labeling, Cell Culture, Derivative Assay