HY-P70493 Search Results


rat macrophage colony  (MedChemExpress)
93
MedChemExpress rat macrophage colony
GSEA and immune infiltration analysis after TAK715 treatment. A The selected KEGG GSEA analysis ES diagram: apoptosis (pathway ID: hsa04210), TNF (pathway ID: hsa04668), IL-17 (pathway ID: hsa04657), MAPK signaling pathway (pathway ID: hsa04010) and TGF-beta signaling pathway (pathway ID: hsa04010). The combined ES diagram was at last. B The combined heatmap of selected pathways in KEGG GSEA analysis. C The selected GO GSEA analysis ES diagram: The collagen binding (GO:0005518), collagen-containing extracellular matrix (GO:0062023), collagen fiber organization (GO:0030199), growth factor activity (GO:0008083) and collagen trimer (GO:0005581). The combined ES diagram was at last. D The combined heatmap of selected pathways in KEGG GO analysis. E The inflammation-collagen interaction chord gram showed that the collagen terms and inflammation pathways are tightly linked. The value between term and pathway was calculated according to the log 2 fold change of common genes. F The heatmap of different immune-cell gene expression in this gene set. The M1 <t>macrophage</t> related genes were more expressed in untreated FS synovial fibroblasts (NC group) compared with TAK715 treated (TAK5 group). G The correlation and p value of immune infiltration result. The M1 macrophage cluster exhibited the correlation of 0.18 and p value of 0.32, which indicated that the M1 macrophage infiltration was positive linked with the FS synovial fibroblasts
Rat Macrophage Colony, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rat macrophage colony/product/MedChemExpress
Average 93 stars, based on 1 article reviews
rat macrophage colony - by Bioz Stars, 2026-02
93/100 stars
  Buy from Supplier

Image Search Results


GSEA and immune infiltration analysis after TAK715 treatment. A The selected KEGG GSEA analysis ES diagram: apoptosis (pathway ID: hsa04210), TNF (pathway ID: hsa04668), IL-17 (pathway ID: hsa04657), MAPK signaling pathway (pathway ID: hsa04010) and TGF-beta signaling pathway (pathway ID: hsa04010). The combined ES diagram was at last. B The combined heatmap of selected pathways in KEGG GSEA analysis. C The selected GO GSEA analysis ES diagram: The collagen binding (GO:0005518), collagen-containing extracellular matrix (GO:0062023), collagen fiber organization (GO:0030199), growth factor activity (GO:0008083) and collagen trimer (GO:0005581). The combined ES diagram was at last. D The combined heatmap of selected pathways in KEGG GO analysis. E The inflammation-collagen interaction chord gram showed that the collagen terms and inflammation pathways are tightly linked. The value between term and pathway was calculated according to the log 2 fold change of common genes. F The heatmap of different immune-cell gene expression in this gene set. The M1 macrophage related genes were more expressed in untreated FS synovial fibroblasts (NC group) compared with TAK715 treated (TAK5 group). G The correlation and p value of immune infiltration result. The M1 macrophage cluster exhibited the correlation of 0.18 and p value of 0.32, which indicated that the M1 macrophage infiltration was positive linked with the FS synovial fibroblasts

Journal: BMC Musculoskeletal Disorders

Article Title: The link between osteoporosis and frozen shoulder: exploring the therapeutic effect of TAK715 on reversing fibrosis and protecting against osteoporosis via the p38 MAPK signaling pathway

doi: 10.1186/s12891-024-08068-8

Figure Lengend Snippet: GSEA and immune infiltration analysis after TAK715 treatment. A The selected KEGG GSEA analysis ES diagram: apoptosis (pathway ID: hsa04210), TNF (pathway ID: hsa04668), IL-17 (pathway ID: hsa04657), MAPK signaling pathway (pathway ID: hsa04010) and TGF-beta signaling pathway (pathway ID: hsa04010). The combined ES diagram was at last. B The combined heatmap of selected pathways in KEGG GSEA analysis. C The selected GO GSEA analysis ES diagram: The collagen binding (GO:0005518), collagen-containing extracellular matrix (GO:0062023), collagen fiber organization (GO:0030199), growth factor activity (GO:0008083) and collagen trimer (GO:0005581). The combined ES diagram was at last. D The combined heatmap of selected pathways in KEGG GO analysis. E The inflammation-collagen interaction chord gram showed that the collagen terms and inflammation pathways are tightly linked. The value between term and pathway was calculated according to the log 2 fold change of common genes. F The heatmap of different immune-cell gene expression in this gene set. The M1 macrophage related genes were more expressed in untreated FS synovial fibroblasts (NC group) compared with TAK715 treated (TAK5 group). G The correlation and p value of immune infiltration result. The M1 macrophage cluster exhibited the correlation of 0.18 and p value of 0.32, which indicated that the M1 macrophage infiltration was positive linked with the FS synovial fibroblasts

Article Snippet: The bone marrow derived macrophages (BMDMs) were cultured according to previous studies and seeded in a six-well plate with 5 × 105 per well and stimulated with rat macrophage colony stimulating factor (M-CSF, MCE, NJ, USA) at 30 ng/ml.

Techniques: Binding Assay, Activity Assay, Gene Expression

the X-ray images ( A , B ), ROM measurement ( C , D ) and histology analysis of FS rat models. A , B The X-rays of FS rats in neutral and abduction position and the statistics analysis of angle measurement in ( A ). ( n = 6) * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001. C , D The ROM measurement of FS rats in neutral and abduction position and the statistics analysis of ROM measurement in ( A ). ( n = 6) * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001. E Representative hematoxylin and eosin-stained (H&E) tissue sections of the shoulder joint. The capsule regions were encircled in dotted rectangle. Scale Bar: 100 μM. F Representative masson-stained tissue sections of the shoulder joint. The capsule regions were encircled in dotted rectangle. Scale Bar: 100 μM. G The statistics analysis of capsular thickness(mm) and macrophage relative counts in ( E ). ( n = 3) * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001

Journal: BMC Musculoskeletal Disorders

Article Title: The link between osteoporosis and frozen shoulder: exploring the therapeutic effect of TAK715 on reversing fibrosis and protecting against osteoporosis via the p38 MAPK signaling pathway

doi: 10.1186/s12891-024-08068-8

Figure Lengend Snippet: the X-ray images ( A , B ), ROM measurement ( C , D ) and histology analysis of FS rat models. A , B The X-rays of FS rats in neutral and abduction position and the statistics analysis of angle measurement in ( A ). ( n = 6) * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001. C , D The ROM measurement of FS rats in neutral and abduction position and the statistics analysis of ROM measurement in ( A ). ( n = 6) * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001. E Representative hematoxylin and eosin-stained (H&E) tissue sections of the shoulder joint. The capsule regions were encircled in dotted rectangle. Scale Bar: 100 μM. F Representative masson-stained tissue sections of the shoulder joint. The capsule regions were encircled in dotted rectangle. Scale Bar: 100 μM. G The statistics analysis of capsular thickness(mm) and macrophage relative counts in ( E ). ( n = 3) * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001

Article Snippet: The bone marrow derived macrophages (BMDMs) were cultured according to previous studies and seeded in a six-well plate with 5 × 105 per well and stimulated with rat macrophage colony stimulating factor (M-CSF, MCE, NJ, USA) at 30 ng/ml.

Techniques: Staining

The pathogenesis mechanism based on the activation of p38 MAPK signal pathway and the therapeutic effect of TAK715. Briefly, the extrinsic or intrinsic reasons produced fibrogenic stimuli and the stimuli triggered synovium fibroblast apoptosis and recruited macrophage infiltration. At the initial pathogenesis phase, the osteoclast was also activated. In this stage, the patients suffered from pain, stiffness and bone loss. Under the cessation of fibrogenic stimuli and consistent cell apoptosis, the ECM secreting is stopped and degraded. The FS comes into thawing phase. Holistically, the TAK715 could correct the fibrosis and local osteoporosis to accelerate the rehabilitation. (Created from https://www.biorender.com )

Journal: BMC Musculoskeletal Disorders

Article Title: The link between osteoporosis and frozen shoulder: exploring the therapeutic effect of TAK715 on reversing fibrosis and protecting against osteoporosis via the p38 MAPK signaling pathway

doi: 10.1186/s12891-024-08068-8

Figure Lengend Snippet: The pathogenesis mechanism based on the activation of p38 MAPK signal pathway and the therapeutic effect of TAK715. Briefly, the extrinsic or intrinsic reasons produced fibrogenic stimuli and the stimuli triggered synovium fibroblast apoptosis and recruited macrophage infiltration. At the initial pathogenesis phase, the osteoclast was also activated. In this stage, the patients suffered from pain, stiffness and bone loss. Under the cessation of fibrogenic stimuli and consistent cell apoptosis, the ECM secreting is stopped and degraded. The FS comes into thawing phase. Holistically, the TAK715 could correct the fibrosis and local osteoporosis to accelerate the rehabilitation. (Created from https://www.biorender.com )

Article Snippet: The bone marrow derived macrophages (BMDMs) were cultured according to previous studies and seeded in a six-well plate with 5 × 105 per well and stimulated with rat macrophage colony stimulating factor (M-CSF, MCE, NJ, USA) at 30 ng/ml.

Techniques: Activation Assay, Produced