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inhibitor g3 c12  (MedChemExpress)
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MedChemExpress inhibitor g3 c12
Myeloid leukemia cells use galectin-1 to block CAR T cells function A , The specific lysis after coculture with U937 CD33 cells at a 1:5 in the presence of recombinant galectin 3 protein (20 µg/ml) and galectin-3 specific inhibitor <t>G3-C12</t> (30 µM). B , The specific lysis after coculture with U937 CD33 cells at a 1:1 in the presence of recombinant galectin 12 protein (10 µg/ml) and galectin 12 antibody. C , The specific lysis, the percentage of CD69 expression in CD33 CAR T cells, and the percentage of surface CAR expression in CD33 CAR T cells, after coculture with U937 CD33 cells at a 1:10 E:T ratio for 12 h, in the presence of 10 µM galectin-1 inhibitory peptide (ANGINEX). D , The specific lysis and the percentage of surface CAR expression in CD33 CAR T cells, after coculture with U937 CD33 cells at a 50 µg/ml recombinant galectin-1 protein. E , The specific lysis and the percentage of surface CAR expression in CD33 CAR T cells, after coculture with U937 CD33 cells at a 1:1 ratio for 12 h in the presence of 10 µM galectin-1 inhibitory peptide (ANGINEX). F, Total number of CD123, CD33,CD19 and CLL-1 CAR-T cells in the experimental group with 50 µg/ml recombinant galectin-1 protein and in the control group. G , Annexin V positivity in CD123, CD33, CD19 and CLL1 CAR-T cells from experimental and control groups using 50 µg/ml recombinant galectin-1 protein
Inhibitor G3 C12, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Myeloid leukemia cells use galectin-1 to block CAR T cells function A , The specific lysis after coculture with U937 CD33 cells at a 1:5 in the presence of recombinant galectin 3 protein (20 µg/ml) and galectin-3 specific inhibitor G3-C12 (30 µM). B , The specific lysis after coculture with U937 CD33 cells at a 1:1 in the presence of recombinant galectin 12 protein (10 µg/ml) and galectin 12 antibody. C , The specific lysis, the percentage of CD69 expression in CD33 CAR T cells, and the percentage of surface CAR expression in CD33 CAR T cells, after coculture with U937 CD33 cells at a 1:10 E:T ratio for 12 h, in the presence of 10 µM galectin-1 inhibitory peptide (ANGINEX). D , The specific lysis and the percentage of surface CAR expression in CD33 CAR T cells, after coculture with U937 CD33 cells at a 50 µg/ml recombinant galectin-1 protein. E , The specific lysis and the percentage of surface CAR expression in CD33 CAR T cells, after coculture with U937 CD33 cells at a 1:1 ratio for 12 h in the presence of 10 µM galectin-1 inhibitory peptide (ANGINEX). F, Total number of CD123, CD33,CD19 and CLL-1 CAR-T cells in the experimental group with 50 µg/ml recombinant galectin-1 protein and in the control group. G , Annexin V positivity in CD123, CD33, CD19 and CLL1 CAR-T cells from experimental and control groups using 50 µg/ml recombinant galectin-1 protein

Journal: Journal of Translational Medicine

Article Title: Myeloid leukemia-derived galectin-1 downregulates CAR expression to hinder cytotoxicity of CAR T cells

doi: 10.1186/s12967-023-04832-x

Figure Lengend Snippet: Myeloid leukemia cells use galectin-1 to block CAR T cells function A , The specific lysis after coculture with U937 CD33 cells at a 1:5 in the presence of recombinant galectin 3 protein (20 µg/ml) and galectin-3 specific inhibitor G3-C12 (30 µM). B , The specific lysis after coculture with U937 CD33 cells at a 1:1 in the presence of recombinant galectin 12 protein (10 µg/ml) and galectin 12 antibody. C , The specific lysis, the percentage of CD69 expression in CD33 CAR T cells, and the percentage of surface CAR expression in CD33 CAR T cells, after coculture with U937 CD33 cells at a 1:10 E:T ratio for 12 h, in the presence of 10 µM galectin-1 inhibitory peptide (ANGINEX). D , The specific lysis and the percentage of surface CAR expression in CD33 CAR T cells, after coculture with U937 CD33 cells at a 50 µg/ml recombinant galectin-1 protein. E , The specific lysis and the percentage of surface CAR expression in CD33 CAR T cells, after coculture with U937 CD33 cells at a 1:1 ratio for 12 h in the presence of 10 µM galectin-1 inhibitory peptide (ANGINEX). F, Total number of CD123, CD33,CD19 and CLL-1 CAR-T cells in the experimental group with 50 µg/ml recombinant galectin-1 protein and in the control group. G , Annexin V positivity in CD123, CD33, CD19 and CLL1 CAR-T cells from experimental and control groups using 50 µg/ml recombinant galectin-1 protein

Article Snippet: We added NH 4 Cl (20 mM), galectin-1 specific inhibitor anginex (Jiangsu Jitai, 10 µM), galectin-3 specific inhibitor G3-C12 (MCE, 30 µM), recombinant galectin-1 protein (Acro, 50 µg/ml), recombinant galectin 3 protein (MCE, 20 µg/ml), recombinant galectin 12 protein (MCE, 10 µg/ml) and galectin 12 antibody (CUSABIO) to the coculture system.

Techniques: Blocking Assay, Lysis, Recombinant, Expressing, Control