HY-P1453A Search Results


cmd178  (MedChemExpress)
90
MedChemExpress cmd178
Effect of β-Car on pulmonary inflammation in neutrophilic asthma. Bronchial asthma was induced in mice by tobacco smoke exposure and ovalbumin stimulation (n=10), and subsequently administered β-Car, SR144528 or <t>CMD178.</t> SR144528 is a β-Car antagonist and CMD178 is a Treg inhibitor. (A) Lung tissue samples of the asthmatic mice were stained with hematoxylin & eosin and observed under a microscope (40×); (B,C,D) levels of inflammatory cytokines (TNF-α, IL-6, IL-8) assessed by ELISA; (E,F) levels of the cytokines IL-10 and TGF-β secreted by Treg as assessed by ELISA; (G,H) levels of the cytokines IL-17A and IL-22 secreted by Th17 as assessed by ELISA. ***P<0.001 vs. Control group; #P<0.05, ###P<0.001 vs. Asthma group; ^P<0.05, ^^P<0.01, ^^^P<0.001 vs. Asthma + β-Car group. β-Car, β-caryophyllene; ELISA, enzyme-linked immunosorbent assay; IL, interleukin; TGF, transforming growth factor; TNF, tumor necrosis factor; Treg, regulatory T cell.
Cmd178, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Effect of β-Car on pulmonary inflammation in neutrophilic asthma. Bronchial asthma was induced in mice by tobacco smoke exposure and ovalbumin stimulation (n=10), and subsequently administered β-Car, SR144528 or CMD178. SR144528 is a β-Car antagonist and CMD178 is a Treg inhibitor. (A) Lung tissue samples of the asthmatic mice were stained with hematoxylin & eosin and observed under a microscope (40×); (B,C,D) levels of inflammatory cytokines (TNF-α, IL-6, IL-8) assessed by ELISA; (E,F) levels of the cytokines IL-10 and TGF-β secreted by Treg as assessed by ELISA; (G,H) levels of the cytokines IL-17A and IL-22 secreted by Th17 as assessed by ELISA. ***P<0.001 vs. Control group; #P<0.05, ###P<0.001 vs. Asthma group; ^P<0.05, ^^P<0.01, ^^^P<0.001 vs. Asthma + β-Car group. β-Car, β-caryophyllene; ELISA, enzyme-linked immunosorbent assay; IL, interleukin; TGF, transforming growth factor; TNF, tumor necrosis factor; Treg, regulatory T cell.

Journal: Annals of Translational Medicine

Article Title: Selective activation of cannabinoid receptor 2 regulates Treg/Th17 balance to ameliorate neutrophilic asthma in mice

doi: 10.21037/atm-21-2778

Figure Lengend Snippet: Effect of β-Car on pulmonary inflammation in neutrophilic asthma. Bronchial asthma was induced in mice by tobacco smoke exposure and ovalbumin stimulation (n=10), and subsequently administered β-Car, SR144528 or CMD178. SR144528 is a β-Car antagonist and CMD178 is a Treg inhibitor. (A) Lung tissue samples of the asthmatic mice were stained with hematoxylin & eosin and observed under a microscope (40×); (B,C,D) levels of inflammatory cytokines (TNF-α, IL-6, IL-8) assessed by ELISA; (E,F) levels of the cytokines IL-10 and TGF-β secreted by Treg as assessed by ELISA; (G,H) levels of the cytokines IL-17A and IL-22 secreted by Th17 as assessed by ELISA. ***P<0.001 vs. Control group; #P<0.05, ###P<0.001 vs. Asthma group; ^P<0.05, ^^P<0.01, ^^^P<0.001 vs. Asthma + β-Car group. β-Car, β-caryophyllene; ELISA, enzyme-linked immunosorbent assay; IL, interleukin; TGF, transforming growth factor; TNF, tumor necrosis factor; Treg, regulatory T cell.

Article Snippet: The Ovalbumin (OVA) (90%, DH015-4) was obtained from Guangzhou Dingguo Biotechnology Co., Ltd. β-Caryophyllene (β-Car; HY-N1415), SR144528 (HY-13439), and CMD178 (HY-P1453) were purchased from MedChemExpress (Monmouth Junction, NJ, USA).

Techniques: Staining, Microscopy, Enzyme-linked Immunosorbent Assay, Control

Effect of β-Car administration on levels of lymphocytes, eosinophils, and neutrophils in mice

Journal: Annals of Translational Medicine

Article Title: Selective activation of cannabinoid receptor 2 regulates Treg/Th17 balance to ameliorate neutrophilic asthma in mice

doi: 10.21037/atm-21-2778

Figure Lengend Snippet: Effect of β-Car administration on levels of lymphocytes, eosinophils, and neutrophils in mice

Article Snippet: The Ovalbumin (OVA) (90%, DH015-4) was obtained from Guangzhou Dingguo Biotechnology Co., Ltd. β-Caryophyllene (β-Car; HY-N1415), SR144528 (HY-13439), and CMD178 (HY-P1453) were purchased from MedChemExpress (Monmouth Junction, NJ, USA).

Techniques: Control

Expression of CNR2 in lung tissue was induced by β-Car. Expression of CNR2 (100× and 400×) in right lung tissue from (A) Control group, (B) Asthma group, (C) Asthma + β-Car group, (D) Asthma + β-Car + SR144528 group and (E) Asthma + β-Car + CMD178 group was showed by immunohistochemical staining. β-Car, β-caryophyllene; CNR2, cannabinoid receptor 2.

Journal: Annals of Translational Medicine

Article Title: Selective activation of cannabinoid receptor 2 regulates Treg/Th17 balance to ameliorate neutrophilic asthma in mice

doi: 10.21037/atm-21-2778

Figure Lengend Snippet: Expression of CNR2 in lung tissue was induced by β-Car. Expression of CNR2 (100× and 400×) in right lung tissue from (A) Control group, (B) Asthma group, (C) Asthma + β-Car group, (D) Asthma + β-Car + SR144528 group and (E) Asthma + β-Car + CMD178 group was showed by immunohistochemical staining. β-Car, β-caryophyllene; CNR2, cannabinoid receptor 2.

Article Snippet: The Ovalbumin (OVA) (90%, DH015-4) was obtained from Guangzhou Dingguo Biotechnology Co., Ltd. β-Caryophyllene (β-Car; HY-N1415), SR144528 (HY-13439), and CMD178 (HY-P1453) were purchased from MedChemExpress (Monmouth Junction, NJ, USA).

Techniques: Expressing, Control, Immunohistochemical staining, Staining