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ca cpr induction  (MedChemExpress)
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MedChemExpress ca cpr induction
Effects of MasR activation or inhibition on neurological deficits and brain damage caused <t>by</t> <t>CA/CPR.</t> (a) Assessment of the NDS ( n = 10 per group). (b) Detection of brain water content ( n = 5 per group). (c) and (d) Serum levels of NSE and S100B 72 h after CA/CPR or sham operation were evaluated by ELISA ( n = 5 per group). ** p < 0.01.
Ca Cpr Induction, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Effects of MasR activation or inhibition on neurological deficits and brain damage caused by CA/CPR. (a) Assessment of the NDS ( n = 10 per group). (b) Detection of brain water content ( n = 5 per group). (c) and (d) Serum levels of NSE and S100B 72 h after CA/CPR or sham operation were evaluated by ELISA ( n = 5 per group). ** p < 0.01.

Journal: Translational Neuroscience

Article Title: The ACE2/Ang-(1-7)/MasR axis alleviates brain injury after cardiopulmonary resuscitation in rabbits by activating PI3K/Akt signaling

doi: 10.1515/tnsci-2022-0334

Figure Lengend Snippet: Effects of MasR activation or inhibition on neurological deficits and brain damage caused by CA/CPR. (a) Assessment of the NDS ( n = 10 per group). (b) Detection of brain water content ( n = 5 per group). (c) and (d) Serum levels of NSE and S100B 72 h after CA/CPR or sham operation were evaluated by ELISA ( n = 5 per group). ** p < 0.01.

Article Snippet: The resuscitated rabbits were grouped as follows: (a) in the sham group, the rabbits were subjected to a sham operation and injected with normal saline; (b) in the CA/CPR group, the rabbits underwent CA/CPR induction and received injections of normal saline; (c) in the CA/CPR + Ang-(1-7) group, the rabbits underwent CA/CPR induction and then received subcutaneous injections of Ang-(1-7) solution (576 μg/kg/day; HY-12403, MedChemExpress, Shanghai, China) immediately after resuscitation; (d) in the CA/CPR + Ang-(1-7) + A779 group, the rabbits underwent CA/CPR induction and received subcutaneous injections of Ang-(1-7) and A779 solution (a MasR antagonist; 576 μg/kg/day; HY-P0216, MedChemExpress) immediately after resuscitation; (e) in the CA/CPR + LY294002 group, the rabbits underwent CA/CPR induction and received intraperitoneal injections of 0.6 mg/kg LY294002 (an inhibitor of PI3K; HY-10108, MedChemExpress) immediately after resuscitation; and (f) in the CA/CPR + Ang-(1-7) + LY294002 group, the rabbits underwent CA/CPR induction and were administered Ang-(1-7) solution (576 μg/kg/day) and 0.6 mg/kg LY294002.

Techniques: Activation Assay, Inhibition, Enzyme-linked Immunosorbent Assay

Inhibiting PI3K/Akt signaling reversed the Ang-(1-7)-induced attenuation of brain damage after CA/CPR. (a) Western blot analysis of PI3K, phosphorylated PI3K, Akt, and phosphorylated Akt protein levels ( n = 5 per group). (b) NDS 24 h after the operation ( n = 10 per group). (c) TUNEL staining showing neuronal apoptosis in the hippocampus ( n = 5 per group). (d) Western blot analysis of cleaved caspase-9, cleaved caspase-3, and cytochrome C protein levels ( n = 5 per group). ** p < 0.01.

Journal: Translational Neuroscience

Article Title: The ACE2/Ang-(1-7)/MasR axis alleviates brain injury after cardiopulmonary resuscitation in rabbits by activating PI3K/Akt signaling

doi: 10.1515/tnsci-2022-0334

Figure Lengend Snippet: Inhibiting PI3K/Akt signaling reversed the Ang-(1-7)-induced attenuation of brain damage after CA/CPR. (a) Western blot analysis of PI3K, phosphorylated PI3K, Akt, and phosphorylated Akt protein levels ( n = 5 per group). (b) NDS 24 h after the operation ( n = 10 per group). (c) TUNEL staining showing neuronal apoptosis in the hippocampus ( n = 5 per group). (d) Western blot analysis of cleaved caspase-9, cleaved caspase-3, and cytochrome C protein levels ( n = 5 per group). ** p < 0.01.

Article Snippet: The resuscitated rabbits were grouped as follows: (a) in the sham group, the rabbits were subjected to a sham operation and injected with normal saline; (b) in the CA/CPR group, the rabbits underwent CA/CPR induction and received injections of normal saline; (c) in the CA/CPR + Ang-(1-7) group, the rabbits underwent CA/CPR induction and then received subcutaneous injections of Ang-(1-7) solution (576 μg/kg/day; HY-12403, MedChemExpress, Shanghai, China) immediately after resuscitation; (d) in the CA/CPR + Ang-(1-7) + A779 group, the rabbits underwent CA/CPR induction and received subcutaneous injections of Ang-(1-7) and A779 solution (a MasR antagonist; 576 μg/kg/day; HY-P0216, MedChemExpress) immediately after resuscitation; (e) in the CA/CPR + LY294002 group, the rabbits underwent CA/CPR induction and received intraperitoneal injections of 0.6 mg/kg LY294002 (an inhibitor of PI3K; HY-10108, MedChemExpress) immediately after resuscitation; and (f) in the CA/CPR + Ang-(1-7) + LY294002 group, the rabbits underwent CA/CPR induction and were administered Ang-(1-7) solution (576 μg/kg/day) and 0.6 mg/kg LY294002.

Techniques: Western Blot, TUNEL Assay, Staining