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storage solutions for oct  (MedChemExpress)
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MedChemExpress storage solutions for oct
Identification of <t>OCT</t> for inhibiting hyphae activity. ( a ) Flow chart of screening an FDA-approved compound library <t>(HY-L022,</t> <t>MCE</t> ® ). ( b ) OCT chemical structure. ( c ) Minimum inhibitory hyphal concentrations of the screened 105 compounds in RMPI 1640 at 37 °C for 4 h. ( d ) Minimum inhibitory hyphal concentrations of the screened 14 compounds in four different hyphae-inducing mediums at 37 °C for 4 h. The red boxes indicate the final compound, Octenidine dihydrochloride (OCT). ( e ) OCT (3.125 μM) blocks C. albicans filamentation in response to diverse inducing cues, including RPMI 1640, Spider media, YPGlcNAc, and YPD + FBS at 37 °C for 4 h. Representative images are shown.
Storage Solutions For Oct, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Identification of OCT for inhibiting hyphae activity. ( a ) Flow chart of screening an FDA-approved compound library (HY-L022, MCE ® ). ( b ) OCT chemical structure. ( c ) Minimum inhibitory hyphal concentrations of the screened 105 compounds in RMPI 1640 at 37 °C for 4 h. ( d ) Minimum inhibitory hyphal concentrations of the screened 14 compounds in four different hyphae-inducing mediums at 37 °C for 4 h. The red boxes indicate the final compound, Octenidine dihydrochloride (OCT). ( e ) OCT (3.125 μM) blocks C. albicans filamentation in response to diverse inducing cues, including RPMI 1640, Spider media, YPGlcNAc, and YPD + FBS at 37 °C for 4 h. Representative images are shown.

Journal: Antibiotics

Article Title: Unexpected Inhibitory Effect of Octenidine Dihydrochloride on Candida albicans Filamentation by Impairing Ergosterol Biosynthesis and Disrupting Cell Membrane Integrity

doi: 10.3390/antibiotics12121675

Figure Lengend Snippet: Identification of OCT for inhibiting hyphae activity. ( a ) Flow chart of screening an FDA-approved compound library (HY-L022, MCE ® ). ( b ) OCT chemical structure. ( c ) Minimum inhibitory hyphal concentrations of the screened 105 compounds in RMPI 1640 at 37 °C for 4 h. ( d ) Minimum inhibitory hyphal concentrations of the screened 14 compounds in four different hyphae-inducing mediums at 37 °C for 4 h. The red boxes indicate the final compound, Octenidine dihydrochloride (OCT). ( e ) OCT (3.125 μM) blocks C. albicans filamentation in response to diverse inducing cues, including RPMI 1640, Spider media, YPGlcNAc, and YPD + FBS at 37 °C for 4 h. Representative images are shown.

Article Snippet: The storage solutions for OCT (5 mM) from MCE in Shanghai, China; FLC (6.4 mg/mL); and AmB (6.4 mg/mL) from Aladdin in Shanghai, China, all utilized DMSO as the solvent, which was sourced from Sangon Biotech in Shanghai, China.

Techniques: Activity Assay, Drug discovery

OCT has potent cytotoxicity and acts as a fungicidal agent. ( a ) MIC of OCT against C. albicans ( n = 19), Candida auris ( n = 4), Candida glabrata ( n = 8), Candida tropical ( n = 12), Candida parapsilosis ( n = 11), Candida krusei ( n = 8), and Candida guilliermondii ( n = 4). ( b ) Growth curve of C. albicans cultured in the presence of 0 μM and 2 μM OCT and 2 μM FLC at 30 °C under shaking conditions. Growth was assessed by measuring OD 600nm every 15 min for 48 h. ( c ) The time-dependent effect of OCT on the growth curve of C. albicans was investigated by culturing the organism in the presence of varying concentrations of OCT (0 μM, 1 μM, 2 μM, and 4 μM) for 24 h at a temperature of 30 °C with shaking. At specific time points (0, 1, 2, 3, 4, 6, 8, 12, and 24 h), the resulting solution was applied onto SDA plates for duplication, and the number of colony-forming units (CFUs) was determined. Statistical analysis was performed using one-way ANOVA followed by Dunnett’s multiple comparisons test to assess the significance of differences. (** p < 0.01, *** p < 0.001, **** p < 0.0001). ( d ) Determination of the minimum fungicidal concentration (MFC) of OCT. ( e ) OCT treatment affects C. albicans viability, as indicated by the number of growing colonies on the plate on 0 μM, 1 μM, and 2 μM OCT treatment.

Journal: Antibiotics

Article Title: Unexpected Inhibitory Effect of Octenidine Dihydrochloride on Candida albicans Filamentation by Impairing Ergosterol Biosynthesis and Disrupting Cell Membrane Integrity

doi: 10.3390/antibiotics12121675

Figure Lengend Snippet: OCT has potent cytotoxicity and acts as a fungicidal agent. ( a ) MIC of OCT against C. albicans ( n = 19), Candida auris ( n = 4), Candida glabrata ( n = 8), Candida tropical ( n = 12), Candida parapsilosis ( n = 11), Candida krusei ( n = 8), and Candida guilliermondii ( n = 4). ( b ) Growth curve of C. albicans cultured in the presence of 0 μM and 2 μM OCT and 2 μM FLC at 30 °C under shaking conditions. Growth was assessed by measuring OD 600nm every 15 min for 48 h. ( c ) The time-dependent effect of OCT on the growth curve of C. albicans was investigated by culturing the organism in the presence of varying concentrations of OCT (0 μM, 1 μM, 2 μM, and 4 μM) for 24 h at a temperature of 30 °C with shaking. At specific time points (0, 1, 2, 3, 4, 6, 8, 12, and 24 h), the resulting solution was applied onto SDA plates for duplication, and the number of colony-forming units (CFUs) was determined. Statistical analysis was performed using one-way ANOVA followed by Dunnett’s multiple comparisons test to assess the significance of differences. (** p < 0.01, *** p < 0.001, **** p < 0.0001). ( d ) Determination of the minimum fungicidal concentration (MFC) of OCT. ( e ) OCT treatment affects C. albicans viability, as indicated by the number of growing colonies on the plate on 0 μM, 1 μM, and 2 μM OCT treatment.

Article Snippet: The storage solutions for OCT (5 mM) from MCE in Shanghai, China; FLC (6.4 mg/mL); and AmB (6.4 mg/mL) from Aladdin in Shanghai, China, all utilized DMSO as the solvent, which was sourced from Sangon Biotech in Shanghai, China.

Techniques: Cell Culture, Concentration Assay

OCT exhibits antifungal efficacy in a G. mellonella infection model. ( a ) Survival curves of larvae infected with SN152 (7.0 × 10 5 cells/larvae) and injected with 0.25 mg/kg, 0.5 mg/kg, 1 mg/kg, and 2 mg/kg doses of OCT or 2 mg/kg doses of FLC. Each curve represents a group of 10 larvae ( n = 10) monitored daily for survival for up to 10 days after infection. ( b ) PAS staining of the larvae. The significance of differences was determined by the Kaplan-Meier method followed by the log-rank test (* p < 0.05, **** p < 0.0001).

Journal: Antibiotics

Article Title: Unexpected Inhibitory Effect of Octenidine Dihydrochloride on Candida albicans Filamentation by Impairing Ergosterol Biosynthesis and Disrupting Cell Membrane Integrity

doi: 10.3390/antibiotics12121675

Figure Lengend Snippet: OCT exhibits antifungal efficacy in a G. mellonella infection model. ( a ) Survival curves of larvae infected with SN152 (7.0 × 10 5 cells/larvae) and injected with 0.25 mg/kg, 0.5 mg/kg, 1 mg/kg, and 2 mg/kg doses of OCT or 2 mg/kg doses of FLC. Each curve represents a group of 10 larvae ( n = 10) monitored daily for survival for up to 10 days after infection. ( b ) PAS staining of the larvae. The significance of differences was determined by the Kaplan-Meier method followed by the log-rank test (* p < 0.05, **** p < 0.0001).

Article Snippet: The storage solutions for OCT (5 mM) from MCE in Shanghai, China; FLC (6.4 mg/mL); and AmB (6.4 mg/mL) from Aladdin in Shanghai, China, all utilized DMSO as the solvent, which was sourced from Sangon Biotech in Shanghai, China.

Techniques: Infection, Injection, Staining