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flumazenil  (MedChemExpress)
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ODN protects cultured astroglial cells from the toxicity induced by 6-OHDA. ( Aa ) Effect of increasing doses of ODN (10 −14 to 10 −8 M) on the survival of cultured astrocytes after 72 h of incubation in the presence or absence of 6-OHDA (120 µM); the ODN was administered during the last 24 h. ( Ab ) Phase-contrast images illustrating the protective effect of ODN (10 −10 M) on morphological changes in astrocytes. ( Ac ) Effect of ODN (10 −10 M) on the release of lactate dehydrogenase. ( B , C ) Effect of ODN on 6-OHDA-induced intracellular ROS and NO accumulation. ( D , E ) Cells were pre-incubated with <t>flumazenil</t> (1 µM) or barbadin (100 µM) for 30 min with medium alone or with 120 µM 6-OHDA, without or with ODN (10 −10 M and 10 −8 M). Cell survival was quantified by measuring FDA fluorescence intensity; the results are expressed as percentages of control. Each value is the mean (±SEM) of at least 12 different wells from 3 independent experiments. We used ANOVA followed by Bonferroni’s test: *** p < 0.001; **** p < 0.0001 vs. control. # p < 0.05; ### p < 0.001; #### p < 0.0001 vs. 6-OHDA-treated cells; ns: not statistically different vs. 6-OHDA-treated cells.
Flumazenil, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ODN protects cultured astroglial cells from the toxicity induced by 6-OHDA. ( Aa ) Effect of increasing doses of ODN (10 −14 to 10 −8 M) on the survival of cultured astrocytes after 72 h of incubation in the presence or absence of 6-OHDA (120 µM); the ODN was administered during the last 24 h. ( Ab ) Phase-contrast images illustrating the protective effect of ODN (10 −10 M) on morphological changes in astrocytes. ( Ac ) Effect of ODN (10 −10 M) on the release of lactate dehydrogenase. ( B , C ) Effect of ODN on 6-OHDA-induced intracellular ROS and NO accumulation. ( D , E ) Cells were pre-incubated with flumazenil (1 µM) or barbadin (100 µM) for 30 min with medium alone or with 120 µM 6-OHDA, without or with ODN (10 −10 M and 10 −8 M). Cell survival was quantified by measuring FDA fluorescence intensity; the results are expressed as percentages of control. Each value is the mean (±SEM) of at least 12 different wells from 3 independent experiments. We used ANOVA followed by Bonferroni’s test: *** p < 0.001; **** p < 0.0001 vs. control. # p < 0.05; ### p < 0.001; #### p < 0.0001 vs. 6-OHDA-treated cells; ns: not statistically different vs. 6-OHDA-treated cells.

Journal: Cells

Article Title: Octadecaneuropeptide, ODN, Promotes Cell Survival against 6-OHDA-Induced Oxidative Stress and Apoptosis by Modulating the Expression of miR-34b, miR-29a, and miR-21in Cultured Astrocytes

doi: 10.3390/cells13141188

Figure Lengend Snippet: ODN protects cultured astroglial cells from the toxicity induced by 6-OHDA. ( Aa ) Effect of increasing doses of ODN (10 −14 to 10 −8 M) on the survival of cultured astrocytes after 72 h of incubation in the presence or absence of 6-OHDA (120 µM); the ODN was administered during the last 24 h. ( Ab ) Phase-contrast images illustrating the protective effect of ODN (10 −10 M) on morphological changes in astrocytes. ( Ac ) Effect of ODN (10 −10 M) on the release of lactate dehydrogenase. ( B , C ) Effect of ODN on 6-OHDA-induced intracellular ROS and NO accumulation. ( D , E ) Cells were pre-incubated with flumazenil (1 µM) or barbadin (100 µM) for 30 min with medium alone or with 120 µM 6-OHDA, without or with ODN (10 −10 M and 10 −8 M). Cell survival was quantified by measuring FDA fluorescence intensity; the results are expressed as percentages of control. Each value is the mean (±SEM) of at least 12 different wells from 3 independent experiments. We used ANOVA followed by Bonferroni’s test: *** p < 0.001; **** p < 0.0001 vs. control. # p < 0.05; ### p < 0.001; #### p < 0.0001 vs. 6-OHDA-treated cells; ns: not statistically different vs. 6-OHDA-treated cells.

Article Snippet: Flumazenil and barbadin were obtained from MedChemExpress (Nonmouth Junction, NJ, USA).

Techniques: Cell Culture, Incubation, Fluorescence, Control