HY-50682A Search Results


ttp488  (MedChemExpress)
94
MedChemExpress ttp488
(A) The latency time of, (B) the time spent by, and (C) the length covered by, the mice from the sham, Aβ1-42+Vehicle, Aβ1-42+5 mg/d <t>TTP488,</t> Aβ1-42+20 mg/d TTP488, and Aβ1-42+50 mg/d TTP488 groups in the platform quadrant in the Morris water maze. (D) Immunofluorescence assay for detecting the expression of NLRP1 and NeuN (×400) and (E) NLRP1/NeuN (+) cells. (F) Nissl staining and (G) Nissl (+) cells in samples from the sham, Aβ1-42+Vehicle, and Aβ1-42+20 mg/d TTP488 groups (Aβ1-42+Vehicle vs . Sham group, ** p <0.05; Aβ1-42+20 mg/d TTP488 vs . Aβ1-4+Vehicle group, ## p <0.05, n=6 per group).
Ttp488, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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(A) The latency time of, (B) the time spent by, and (C) the length covered by, the mice from the sham, Aβ1-42+Vehicle, Aβ1-42+5 mg/d TTP488, Aβ1-42+20 mg/d TTP488, and Aβ1-42+50 mg/d TTP488 groups in the platform quadrant in the Morris water maze. (D) Immunofluorescence assay for detecting the expression of NLRP1 and NeuN (×400) and (E) NLRP1/NeuN (+) cells. (F) Nissl staining and (G) Nissl (+) cells in samples from the sham, Aβ1-42+Vehicle, and Aβ1-42+20 mg/d TTP488 groups (Aβ1-42+Vehicle vs . Sham group, ** p <0.05; Aβ1-42+20 mg/d TTP488 vs . Aβ1-4+Vehicle group, ## p <0.05, n=6 per group).

Journal: Clinics

Article Title: Azeliragon ameliorates Alzheimer's disease via the Janus tyrosine kinase and signal transducer and activator of transcription signaling pathway

doi: 10.6061/clinics/2021/e2348

Figure Lengend Snippet: (A) The latency time of, (B) the time spent by, and (C) the length covered by, the mice from the sham, Aβ1-42+Vehicle, Aβ1-42+5 mg/d TTP488, Aβ1-42+20 mg/d TTP488, and Aβ1-42+50 mg/d TTP488 groups in the platform quadrant in the Morris water maze. (D) Immunofluorescence assay for detecting the expression of NLRP1 and NeuN (×400) and (E) NLRP1/NeuN (+) cells. (F) Nissl staining and (G) Nissl (+) cells in samples from the sham, Aβ1-42+Vehicle, and Aβ1-42+20 mg/d TTP488 groups (Aβ1-42+Vehicle vs . Sham group, ** p <0.05; Aβ1-42+20 mg/d TTP488 vs . Aβ1-4+Vehicle group, ## p <0.05, n=6 per group).

Article Snippet: Tofacitinib (S5001, Selleck, Texas, USA), fludarabine (S1491, Selleck, Texas, USA), TUNEL reaction solution (ab66108, Abcam, Cambridge, UK), TTP488 (HY-50682, MedChem Express, Sollentuna, Sweden), LPS (L8880, Solarbio, Beijing, China), caspase-1 ELISA kits (KL15200, KALANG, Shanghai, China), IL-1β ELISA kits (RLB00, R&D Systems, Minneapolis, USA), IL-18 LISA kits (ab213909, Abcam, Cambridge, UK), Anti-NLRP1 antibody (ab3683, Abcam, Cambridge, UK), anti-NeuN antibody (ab177487, Abcam, Cambridge, UK), Anti-caspase-1 antibody (BM4291, Boster, Wuhan, China), Anti-IL-1β antibody (ab9722, Abcam, Cambridge, UK), Anti-IL-18 antibody (PB0058, Boster, Wuhan, China), anti-β-actin antibody (Boster, BA2305, Wuhan, China), followed by secondary antibodies conjugated to horseradish peroxidase anti-rabbit IgG (H+L) (AS014, ABclonal, Wuhan, China), and anti-mouse IgG (H+L) (AS003, ABclonal, Wuhan, China) were used in this study.

Techniques: Immunofluorescence, Expressing, Staining

(A) The latency time of, (B) the time spent by, and (C) the length covered by, the mice in the platform quadrant in the Morris water maze. (D) TUNEL Immunofluorescence assay (×400). (E) TUNEL (+) cells in samples from the sham, Aβ1-42, Aβ1-42+LPS, and Aβ1-42+LPS+TTP488 groups. (F) The latency time, (G) the time, and (H) the length covered in the platform quadrant in the Morris water maze. (I) TUNEL immunofluorescence assay (×400) and (J) TUNEL (+) cells in samples from the sham, Aβ1-42, Aβ1-42+control oeNLRP1, Aβ1-42+oeNLRP1, and Aβ1-42+oeNLRP1+TTP488 groups (Aβ1-42+LPS or Aβ1-42+oeNLRP1 vs . Aβ1-42 group, ** p <0.05; Aβ1-42+LPS+TTP488 or Aβ1-42+oeNLRP1+TTP488 vs . Aβ1-42+LPS or Aβ1-42+oeNLRP1 group, ## p <0.05, n=6 per group).

Journal: Clinics

Article Title: Azeliragon ameliorates Alzheimer's disease via the Janus tyrosine kinase and signal transducer and activator of transcription signaling pathway

doi: 10.6061/clinics/2021/e2348

Figure Lengend Snippet: (A) The latency time of, (B) the time spent by, and (C) the length covered by, the mice in the platform quadrant in the Morris water maze. (D) TUNEL Immunofluorescence assay (×400). (E) TUNEL (+) cells in samples from the sham, Aβ1-42, Aβ1-42+LPS, and Aβ1-42+LPS+TTP488 groups. (F) The latency time, (G) the time, and (H) the length covered in the platform quadrant in the Morris water maze. (I) TUNEL immunofluorescence assay (×400) and (J) TUNEL (+) cells in samples from the sham, Aβ1-42, Aβ1-42+control oeNLRP1, Aβ1-42+oeNLRP1, and Aβ1-42+oeNLRP1+TTP488 groups (Aβ1-42+LPS or Aβ1-42+oeNLRP1 vs . Aβ1-42 group, ** p <0.05; Aβ1-42+LPS+TTP488 or Aβ1-42+oeNLRP1+TTP488 vs . Aβ1-42+LPS or Aβ1-42+oeNLRP1 group, ## p <0.05, n=6 per group).

Article Snippet: Tofacitinib (S5001, Selleck, Texas, USA), fludarabine (S1491, Selleck, Texas, USA), TUNEL reaction solution (ab66108, Abcam, Cambridge, UK), TTP488 (HY-50682, MedChem Express, Sollentuna, Sweden), LPS (L8880, Solarbio, Beijing, China), caspase-1 ELISA kits (KL15200, KALANG, Shanghai, China), IL-1β ELISA kits (RLB00, R&D Systems, Minneapolis, USA), IL-18 LISA kits (ab213909, Abcam, Cambridge, UK), Anti-NLRP1 antibody (ab3683, Abcam, Cambridge, UK), anti-NeuN antibody (ab177487, Abcam, Cambridge, UK), Anti-caspase-1 antibody (BM4291, Boster, Wuhan, China), Anti-IL-1β antibody (ab9722, Abcam, Cambridge, UK), Anti-IL-18 antibody (PB0058, Boster, Wuhan, China), anti-β-actin antibody (Boster, BA2305, Wuhan, China), followed by secondary antibodies conjugated to horseradish peroxidase anti-rabbit IgG (H+L) (AS014, ABclonal, Wuhan, China), and anti-mouse IgG (H+L) (AS003, ABclonal, Wuhan, China) were used in this study.

Techniques: TUNEL Assay, Immunofluorescence, Control