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sr2211  (MedChemExpress)
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MedChemExpress sr2211
<t>SR2211,</t> the inverse agonist of RORγ, attenuated the sweat secretion and Th17 lymphocyte related inflammatory response in hyperhidrosis mice. Mice were administered with vehicle or SR2211 for one week before the induction of hyperhidrosis, as shown in (A) . The number of black dots were calculated (B) . The number of sweat secretory granules were counted (C) and the concentration of acetylcholine in serum was detected by ELISA (D) . Th17 lymphocyte subpopulations in peripheral blood of the mice were compared (E) . The serum levels of IL-17 (F) and IL-6 (G) were measured by ELISA. Western blotting was used to detect the protein expression of IL-17A in the sweat gland of hyperhidrosis mice (H) . GAPDH was used as a loading control and the expressions were normalized to control (I) . The data were presented with mean ± SD. n = 8 for each group. **p < 0.01, ***p < 0.001 from Brown-Forsythe ANOVA test followed by Dunnett’s T3 multiple comparisons test.
Sr2211, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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SR2211, the inverse agonist of RORγ, attenuated the sweat secretion and Th17 lymphocyte related inflammatory response in hyperhidrosis mice. Mice were administered with vehicle or SR2211 for one week before the induction of hyperhidrosis, as shown in (A) . The number of black dots were calculated (B) . The number of sweat secretory granules were counted (C) and the concentration of acetylcholine in serum was detected by ELISA (D) . Th17 lymphocyte subpopulations in peripheral blood of the mice were compared (E) . The serum levels of IL-17 (F) and IL-6 (G) were measured by ELISA. Western blotting was used to detect the protein expression of IL-17A in the sweat gland of hyperhidrosis mice (H) . GAPDH was used as a loading control and the expressions were normalized to control (I) . The data were presented with mean ± SD. n = 8 for each group. **p < 0.01, ***p < 0.001 from Brown-Forsythe ANOVA test followed by Dunnett’s T3 multiple comparisons test.

Journal: Frontiers in Immunology

Article Title: Altered Th17/Treg balance and therapeutic targeting of RORγ in primary focal hyperhidrosis

doi: 10.3389/fimmu.2025.1656632

Figure Lengend Snippet: SR2211, the inverse agonist of RORγ, attenuated the sweat secretion and Th17 lymphocyte related inflammatory response in hyperhidrosis mice. Mice were administered with vehicle or SR2211 for one week before the induction of hyperhidrosis, as shown in (A) . The number of black dots were calculated (B) . The number of sweat secretory granules were counted (C) and the concentration of acetylcholine in serum was detected by ELISA (D) . Th17 lymphocyte subpopulations in peripheral blood of the mice were compared (E) . The serum levels of IL-17 (F) and IL-6 (G) were measured by ELISA. Western blotting was used to detect the protein expression of IL-17A in the sweat gland of hyperhidrosis mice (H) . GAPDH was used as a loading control and the expressions were normalized to control (I) . The data were presented with mean ± SD. n = 8 for each group. **p < 0.01, ***p < 0.001 from Brown-Forsythe ANOVA test followed by Dunnett’s T3 multiple comparisons test.

Article Snippet: SR2211 was purchased from MedChemExpress (MCE, Cat# HY-16998).

Techniques: Concentration Assay, Enzyme-linked Immunosorbent Assay, Western Blot, Expressing, Control