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pnu 159682  (MedChemExpress)
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MedChemExpress pnu 159682
a PC-3 and PC-42 organoid growth inhibition by EBET and reference compounds. Data are presented as means ± standard deviation ( n = 4 biological replicates for EBET, n = 2 biological replicates for others). Fitted curves with nonlinear regression are shown. GEM: gemcitabine; PTX: paclitaxel; ERL: erlotinib; 5FU: 5-fluorouracil; SN38: an active metabolite of irinotecan; OXA: oxaliplatin; MAY: maytansine; MMAE: monomethyl auristatin E; EXA: exatecan; PNU: <t>PNU-159682;</t> CALI: calicheamicin; SJG: SJG-136. b Inhibition of stromal signaling by GEM and EBET in co-culture of PC-3 cells and liver stellate cells (LSCs). Signal intensity was normalized by the viability of LSCs, and relative values against the signal in monoculture of LSCs are presented as means ± standard deviation ( n = 4 biological replicates). Fitted curves with nonlinear regression are shown. c Immunofluorescence staining of E-cadherin, BC2LCN, and Ki-67 in organoids. Representative images are shown from 2 independent experiments with similar results. Scale bars, 50 μm. a , b Source data are provided as a Source data file.
Pnu 159682, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pnu 159682 - by Bioz Stars, 2026-02
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a PC-3 and PC-42 organoid growth inhibition by EBET and reference compounds. Data are presented as means ± standard deviation ( n = 4 biological replicates for EBET, n = 2 biological replicates for others). Fitted curves with nonlinear regression are shown. GEM: gemcitabine; PTX: paclitaxel; ERL: erlotinib; 5FU: 5-fluorouracil; SN38: an active metabolite of irinotecan; OXA: oxaliplatin; MAY: maytansine; MMAE: monomethyl auristatin E; EXA: exatecan; PNU: PNU-159682; CALI: calicheamicin; SJG: SJG-136. b Inhibition of stromal signaling by GEM and EBET in co-culture of PC-3 cells and liver stellate cells (LSCs). Signal intensity was normalized by the viability of LSCs, and relative values against the signal in monoculture of LSCs are presented as means ± standard deviation ( n = 4 biological replicates). Fitted curves with nonlinear regression are shown. c Immunofluorescence staining of E-cadherin, BC2LCN, and Ki-67 in organoids. Representative images are shown from 2 independent experiments with similar results. Scale bars, 50 μm. a , b Source data are provided as a Source data file.

Journal: Nature Communications

Article Title: Delivery of a BET protein degrader via a CEACAM6-targeted antibody–drug conjugate inhibits tumour growth in pancreatic cancer models

doi: 10.1038/s41467-024-46167-1

Figure Lengend Snippet: a PC-3 and PC-42 organoid growth inhibition by EBET and reference compounds. Data are presented as means ± standard deviation ( n = 4 biological replicates for EBET, n = 2 biological replicates for others). Fitted curves with nonlinear regression are shown. GEM: gemcitabine; PTX: paclitaxel; ERL: erlotinib; 5FU: 5-fluorouracil; SN38: an active metabolite of irinotecan; OXA: oxaliplatin; MAY: maytansine; MMAE: monomethyl auristatin E; EXA: exatecan; PNU: PNU-159682; CALI: calicheamicin; SJG: SJG-136. b Inhibition of stromal signaling by GEM and EBET in co-culture of PC-3 cells and liver stellate cells (LSCs). Signal intensity was normalized by the viability of LSCs, and relative values against the signal in monoculture of LSCs are presented as means ± standard deviation ( n = 4 biological replicates). Fitted curves with nonlinear regression are shown. c Immunofluorescence staining of E-cadherin, BC2LCN, and Ki-67 in organoids. Representative images are shown from 2 independent experiments with similar results. Scale bars, 50 μm. a , b Source data are provided as a Source data file.

Article Snippet: GEM, PTX, erlotinib, 5FU, SN38, oxaliplatin, maytansine, MMAE, exatecan, PNU-159682, chalicheamicin, SJG-136, JQ1, and dBET6 were purchased from Astatech, FUJIFILM Wako Pure Chemical Corporation, LKT Laboratories, Sigma-Aldrich, Shanghai Sunway Pharmaceutical Technology, Xdcexplorer, Concortis Biosystems, Shanghai Haoyuan Chemexpress, Amadis Chemical, and MedChemexpress.

Techniques: Inhibition, Standard Deviation, Co-Culture Assay, Immunofluorescence, Staining