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x 376  (MedChemExpress)
94
MedChemExpress x 376
Chemical structure of <t>X-376.</t>
X 376, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 94 stars, based on 1 article reviews
x 376 - by Bioz Stars, 2026-02
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Chemical structure of X-376.

Journal: RSC Advances

Article Title: Phase I metabolic profiling and unexpected reactive metabolites in human liver microsome incubations of X-376 using LC-MS/MS: bioactivation pathway elucidation and in silico toxicity studies of its metabolites

doi: 10.1039/c9ra09115g

Figure Lengend Snippet: Chemical structure of X-376.

Article Snippet: X-376 , Med Chem. Express company.

Techniques:

Proposed metabolic sites for X-376 by StarDrop WhichP450™ model.

Journal: RSC Advances

Article Title: Phase I metabolic profiling and unexpected reactive metabolites in human liver microsome incubations of X-376 using LC-MS/MS: bioactivation pathway elucidation and in silico toxicity studies of its metabolites

doi: 10.1039/c9ra09115g

Figure Lengend Snippet: Proposed metabolic sites for X-376 by StarDrop WhichP450™ model.

Article Snippet: X-376 , Med Chem. Express company.

Techniques:

DEREK outcomes showing structural alerts with the proposed side effects of X-376. Red color indicates the structural alerts.

Journal: RSC Advances

Article Title: Phase I metabolic profiling and unexpected reactive metabolites in human liver microsome incubations of X-376 using LC-MS/MS: bioactivation pathway elucidation and in silico toxicity studies of its metabolites

doi: 10.1039/c9ra09115g

Figure Lengend Snippet: DEREK outcomes showing structural alerts with the proposed side effects of X-376. Red color indicates the structural alerts.

Article Snippet: X-376 , Med Chem. Express company.

Techniques:

Product ion chromatogram at m / z 547 showing the X-376 peak at 38.9 min (A). Product ion mass spectrum of X-376 (B).

Journal: RSC Advances

Article Title: Phase I metabolic profiling and unexpected reactive metabolites in human liver microsome incubations of X-376 using LC-MS/MS: bioactivation pathway elucidation and in silico toxicity studies of its metabolites

doi: 10.1039/c9ra09115g

Figure Lengend Snippet: Product ion chromatogram at m / z 547 showing the X-376 peak at 38.9 min (A). Product ion mass spectrum of X-376 (B).

Article Snippet: X-376 , Med Chem. Express company.

Techniques:

X-376 MS/MS fragments.

Journal: RSC Advances

Article Title: Phase I metabolic profiling and unexpected reactive metabolites in human liver microsome incubations of X-376 using LC-MS/MS: bioactivation pathway elucidation and in silico toxicity studies of its metabolites

doi: 10.1039/c9ra09115g

Figure Lengend Snippet: X-376 MS/MS fragments.

Article Snippet: X-376 , Med Chem. Express company.

Techniques: Tandem Mass Spectroscopy

Supposed pathways for reactive iminium intermediate generation in X-376 metabolism and the possible capturing strategy.

Journal: RSC Advances

Article Title: Phase I metabolic profiling and unexpected reactive metabolites in human liver microsome incubations of X-376 using LC-MS/MS: bioactivation pathway elucidation and in silico toxicity studies of its metabolites

doi: 10.1039/c9ra09115g

Figure Lengend Snippet: Supposed pathways for reactive iminium intermediate generation in X-376 metabolism and the possible capturing strategy.

Article Snippet: X-376 , Med Chem. Express company.

Techniques:

X-376 chemical structure indicating different metabolic phase I pathways and the corresponding bioactive centers.

Journal: RSC Advances

Article Title: Phase I metabolic profiling and unexpected reactive metabolites in human liver microsome incubations of X-376 using LC-MS/MS: bioactivation pathway elucidation and in silico toxicity studies of its metabolites

doi: 10.1039/c9ra09115g

Figure Lengend Snippet: X-376 chemical structure indicating different metabolic phase I pathways and the corresponding bioactive centers.

Article Snippet: X-376 , Med Chem. Express company.

Techniques: