HY-162735 Search Results


opb  (MedChemExpress)
92
MedChemExpress opb
Opb, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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nanotube inhibitors  (MedChemExpress)
94
MedChemExpress nanotube inhibitors
Hybrids enhance the immunosuppressive function of iDCs and their underlying mechanisms. Flow cytometry sorting and detection of proliferation(A) and PDL-1 levels in total iDCs(B) and the iDCs with obtaining hybrid membrane components(I) after co-culture with hybrids. Live-cell imaging observations revealed that hybrids influence iDCs through cell migration(C), <t>nanotube</t> interactions(D and G), efferocytosis(E), label tracking(F), and label pulling(H). The impact of CK636(J), Dynasore(K) and L778123(L) on the proportion of iDCs cells with hybrid membrane components (DiD + GFP + ) and PDL-1 levels. Data are represented as means±SD (n=3). **P<0.01, ***P<0.001 vs DC 24h in A(two-tailed t-test); ***P<0.001 vs DC and ### P<0.001 vs Hybrid+DC in B(One-way ANOVA Tukey’s multiple comparison); ***P<0.001 vs DC in I(two-tailed t-test); *P<0.05, **P<0.01 vs -IFN-γ/IL-1β and # P<0.05, ## P<0.01, ### P<0.001 vs <t>-CK636/-Dy/-L77</t> in J-L(two-tailed t-test).
Nanotube Inhibitors, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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hy 16273a human daxx abcam  (MedChemExpress)
93
MedChemExpress hy 16273a human daxx abcam
Hybrids enhance the immunosuppressive function of iDCs and their underlying mechanisms. Flow cytometry sorting and detection of proliferation(A) and PDL-1 levels in total iDCs(B) and the iDCs with obtaining hybrid membrane components(I) after co-culture with hybrids. Live-cell imaging observations revealed that hybrids influence iDCs through cell migration(C), <t>nanotube</t> interactions(D and G), efferocytosis(E), label tracking(F), and label pulling(H). The impact of CK636(J), Dynasore(K) and L778123(L) on the proportion of iDCs cells with hybrid membrane components (DiD + GFP + ) and PDL-1 levels. Data are represented as means±SD (n=3). **P<0.01, ***P<0.001 vs DC 24h in A(two-tailed t-test); ***P<0.001 vs DC and ### P<0.001 vs Hybrid+DC in B(One-way ANOVA Tukey’s multiple comparison); ***P<0.001 vs DC in I(two-tailed t-test); *P<0.05, **P<0.01 vs -IFN-γ/IL-1β and # P<0.05, ## P<0.01, ### P<0.001 vs <t>-CK636/-Dy/-L77</t> in J-L(two-tailed t-test).
Hy 16273a Human Daxx Abcam, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Hybrids enhance the immunosuppressive function of iDCs and their underlying mechanisms. Flow cytometry sorting and detection of proliferation(A) and PDL-1 levels in total iDCs(B) and the iDCs with obtaining hybrid membrane components(I) after co-culture with hybrids. Live-cell imaging observations revealed that hybrids influence iDCs through cell migration(C), nanotube interactions(D and G), efferocytosis(E), label tracking(F), and label pulling(H). The impact of CK636(J), Dynasore(K) and L778123(L) on the proportion of iDCs cells with hybrid membrane components (DiD + GFP + ) and PDL-1 levels. Data are represented as means±SD (n=3). **P<0.01, ***P<0.001 vs DC 24h in A(two-tailed t-test); ***P<0.001 vs DC and ### P<0.001 vs Hybrid+DC in B(One-way ANOVA Tukey’s multiple comparison); ***P<0.001 vs DC in I(two-tailed t-test); *P<0.05, **P<0.01 vs -IFN-γ/IL-1β and # P<0.05, ## P<0.01, ### P<0.001 vs -CK636/-Dy/-L77 in J-L(two-tailed t-test).

Journal: bioRxiv

Article Title: Construction, Phenotypic Characterization, and Immunomodulatory Function Study of BMSC-Macrophage Hybrid in vitro

doi: 10.1101/2025.07.25.666751

Figure Lengend Snippet: Hybrids enhance the immunosuppressive function of iDCs and their underlying mechanisms. Flow cytometry sorting and detection of proliferation(A) and PDL-1 levels in total iDCs(B) and the iDCs with obtaining hybrid membrane components(I) after co-culture with hybrids. Live-cell imaging observations revealed that hybrids influence iDCs through cell migration(C), nanotube interactions(D and G), efferocytosis(E), label tracking(F), and label pulling(H). The impact of CK636(J), Dynasore(K) and L778123(L) on the proportion of iDCs cells with hybrid membrane components (DiD + GFP + ) and PDL-1 levels. Data are represented as means±SD (n=3). **P<0.01, ***P<0.001 vs DC 24h in A(two-tailed t-test); ***P<0.001 vs DC and ### P<0.001 vs Hybrid+DC in B(One-way ANOVA Tukey’s multiple comparison); ***P<0.001 vs DC in I(two-tailed t-test); *P<0.05, **P<0.01 vs -IFN-γ/IL-1β and # P<0.05, ## P<0.01, ### P<0.001 vs -CK636/-Dy/-L77 in J-L(two-tailed t-test).

Article Snippet: To clarify the mechanism of membrane transfer between the two cell types, the hybrids were treated with nanotube inhibitors (L-778123, L77, MCE, HY-16273) and migrasome inhibitors (Dynasore, Dy, MCE HY-15304 and CK636, MCE HY-15892) for 8 hours prior to being co-cultured with iDCs for another 24 hours.

Techniques: Flow Cytometry, Membrane, Co-Culture Assay, Live Cell Imaging, Migration, Two Tailed Test, Comparison