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k145  (MedChemExpress)
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MedChemExpress k145
Effects of <t>K145</t> on ion channels. (a–b) Representative sodium currents recorded in SH-SY5Y cells before (a) and after (b) application of 60 μM K145. The currents were induced using 20 ms depolarizing steps (−80 to +20 mV, 5 mV step; Vh = −80 mV). (c) Amplitudes of sodium current (elicited with 0 mV depolarization) normalized to those measured in the absence of K145. (d) Representative calcium currents recorded in SH-SY5Y cells before and after K145 application. (e) Calcium current densities in (D). (f–m) Potassium currents recorded in HEK293T cells expressing K V 4.2 (f–g), K V 1.4 (h–i), BK (j–k) and K2P2.1 (l–m). Representative currents (elicited using +100 mV depolarization) are shown in (f,h,j,l). Persistent currents normalized to those measured in the absence of K145 are shown in (g,i,k,m).
K145, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Effects of K145 on ion channels. (a–b) Representative sodium currents recorded in SH-SY5Y cells before (a) and after (b) application of 60 μM K145. The currents were induced using 20 ms depolarizing steps (−80 to +20 mV, 5 mV step; Vh = −80 mV). (c) Amplitudes of sodium current (elicited with 0 mV depolarization) normalized to those measured in the absence of K145. (d) Representative calcium currents recorded in SH-SY5Y cells before and after K145 application. (e) Calcium current densities in (D). (f–m) Potassium currents recorded in HEK293T cells expressing K V 4.2 (f–g), K V 1.4 (h–i), BK (j–k) and K2P2.1 (l–m). Representative currents (elicited using +100 mV depolarization) are shown in (f,h,j,l). Persistent currents normalized to those measured in the absence of K145 are shown in (g,i,k,m).

Journal: Channels

Article Title: Sphingosine kinase 2 inhibitor ABC294640 suppresses neuronal excitability and inhibits multiple endogenously and exogenously expressed voltage-gated ion channels in cultured cells

doi: 10.1080/19336950.2020.1788364

Figure Lengend Snippet: Effects of K145 on ion channels. (a–b) Representative sodium currents recorded in SH-SY5Y cells before (a) and after (b) application of 60 μM K145. The currents were induced using 20 ms depolarizing steps (−80 to +20 mV, 5 mV step; Vh = −80 mV). (c) Amplitudes of sodium current (elicited with 0 mV depolarization) normalized to those measured in the absence of K145. (d) Representative calcium currents recorded in SH-SY5Y cells before and after K145 application. (e) Calcium current densities in (D). (f–m) Potassium currents recorded in HEK293T cells expressing K V 4.2 (f–g), K V 1.4 (h–i), BK (j–k) and K2P2.1 (l–m). Representative currents (elicited using +100 mV depolarization) are shown in (f,h,j,l). Persistent currents normalized to those measured in the absence of K145 are shown in (g,i,k,m).

Article Snippet: K145 (MedChemExpress) was dissolved in H 2 O to make a 10 mM stock solution.

Techniques: Expressing