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db07268  (MedChemExpress)
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MedChemExpress db07268
JNK1 inhibitor <t>(DB07268)</t> can rescue the synergistic effect caused by co-treatment with PAT and CdCl 2 . ( A ) Effect of DB07268 on PAT/CdCl 2 -induced cell death. The cells were treated with the combination of PAT and CdCl 2 or the combination plus DB07268 for 24 h, and then, cell death was measured. ( B ) Effect of DB07268 on PAT/CdCl 2 -induced ROS generation. The cells were incubated with the combination of PAT and CdCl 2 or the combination plus DB07268 for 12 h, and ROS levels were detected by using DCFH-DA. ( C ) Effect of DB07268 on activation of p53 and Bim induced by PAT and CdCl 2 . AML12 cells were incubated with the combination of PAT and CdCl 2 or the combination plus DB07268 for 24 h, and then, p53, p-p53 and Bim were measured by Western blotting. n = 3, * P < 0.05 and *** P < 0.001.
Db07268, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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JNK1 inhibitor (DB07268) can rescue the synergistic effect caused by co-treatment with PAT and CdCl 2 . ( A ) Effect of DB07268 on PAT/CdCl 2 -induced cell death. The cells were treated with the combination of PAT and CdCl 2 or the combination plus DB07268 for 24 h, and then, cell death was measured. ( B ) Effect of DB07268 on PAT/CdCl 2 -induced ROS generation. The cells were incubated with the combination of PAT and CdCl 2 or the combination plus DB07268 for 12 h, and ROS levels were detected by using DCFH-DA. ( C ) Effect of DB07268 on activation of p53 and Bim induced by PAT and CdCl 2 . AML12 cells were incubated with the combination of PAT and CdCl 2 or the combination plus DB07268 for 24 h, and then, p53, p-p53 and Bim were measured by Western blotting. n = 3, * P < 0.05 and *** P < 0.001.

Journal: Toxins

Article Title: Combining Patulin with Cadmium Induces Enhanced Hepatotoxicity and Nephrotoxicity In Vitro and In Vivo

doi: 10.3390/toxins13030221

Figure Lengend Snippet: JNK1 inhibitor (DB07268) can rescue the synergistic effect caused by co-treatment with PAT and CdCl 2 . ( A ) Effect of DB07268 on PAT/CdCl 2 -induced cell death. The cells were treated with the combination of PAT and CdCl 2 or the combination plus DB07268 for 24 h, and then, cell death was measured. ( B ) Effect of DB07268 on PAT/CdCl 2 -induced ROS generation. The cells were incubated with the combination of PAT and CdCl 2 or the combination plus DB07268 for 12 h, and ROS levels were detected by using DCFH-DA. ( C ) Effect of DB07268 on activation of p53 and Bim induced by PAT and CdCl 2 . AML12 cells were incubated with the combination of PAT and CdCl 2 or the combination plus DB07268 for 24 h, and then, p53, p-p53 and Bim were measured by Western blotting. n = 3, * P < 0.05 and *** P < 0.001.

Article Snippet: DB07268 was purchased from Med Chem Express (Danvers, MA, USA.).

Techniques: Incubation, Activation Assay, Western Blot