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semapimod  (MedChemExpress)
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MedChemExpress semapimod
( A ) Optimization of TCB-32 based on the four different regions: I Aminoguanidine arm, II Linker connection, III Linker region and IV Tripod region. ( B ) Proliferative activity of the structurally similar compound 13 <t>(CNI-1493/Semapimod)</t> (n = 4, SD, z’ = 0.78). ( C ) Proliferative activity of the three most promising analogs (left) TCB-541 (n = 4, SD, z’ = 0.78, (middle) TCB-494 and (right) TCB-621 (n = 4, SD, z’ = 0.71).
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( A ) Optimization of TCB-32 based on the four different regions: I Aminoguanidine arm, II Linker connection, III Linker region and IV Tripod region. ( B ) Proliferative activity of the structurally similar compound 13 (CNI-1493/Semapimod) (n = 4, SD, z’ = 0.78). ( C ) Proliferative activity of the three most promising analogs (left) TCB-541 (n = 4, SD, z’ = 0.78, (middle) TCB-494 and (right) TCB-621 (n = 4, SD, z’ = 0.71).

Journal: Biochemistry and Biophysics Reports

Article Title: Discovery and optimization of a guanylhydrazone-based small molecule to replace bFGF for cell culture applications

doi: 10.1016/j.bbrep.2025.102167

Figure Lengend Snippet: ( A ) Optimization of TCB-32 based on the four different regions: I Aminoguanidine arm, II Linker connection, III Linker region and IV Tripod region. ( B ) Proliferative activity of the structurally similar compound 13 (CNI-1493/Semapimod) (n = 4, SD, z’ = 0.78). ( C ) Proliferative activity of the three most promising analogs (left) TCB-541 (n = 4, SD, z’ = 0.78, (middle) TCB-494 and (right) TCB-621 (n = 4, SD, z’ = 0.71).

Article Snippet: Semapimod , Molport/MedChemExpress , MolPort-047-482-892.

Techniques: Activity Assay