HY-154655 Search Results


kn-93  (MedChemExpress)
94
MedChemExpress kn-93
Kn 93, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/kn-93/product/MedChemExpress
Average 94 stars, based on 1 article reviews
kn-93 - by Bioz Stars, 2026-02
94/100 stars
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kn-93 hydrochloride  (MedChemExpress)
95
MedChemExpress kn-93 hydrochloride
Kn 93 Hydrochloride, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/kn-93 hydrochloride/product/MedChemExpress
Average 95 stars, based on 1 article reviews
kn-93 hydrochloride - by Bioz Stars, 2026-02
95/100 stars
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camkii inhibitor kn93  (MedChemExpress)
94
MedChemExpress camkii inhibitor kn93
Lonafarnib administration affects CaMKII signaling pathways, partially modulating the membrane expression of a7nAChR. (A and B) Levels of phospho-PKC and phospho-PKA in the hippocampus of control and lonafarnib-treated mice treated with vehicle, RG108, or anisomycin. (C) Levels of phospho-CaMKII in the hippocampus of control and lonafarnib-treated mice treated with vehicle, RG108, or anisomycin. ** P < 0.01 vs. control mice (two-way ANOVA, followed by Tukey’s multiple comparison test). (D) Levels of biotinylated a7nAChR (membrane) protein in the hippocampus of control and lonafarnib-treated mice treated with vehicle or CaMKII pathway blocker <t>KN93.</t> Surface a7nAChR was normalized by surface GluR2 protein, which was again normalized by vehicle-treated control group. ** P < 0.01 vs. control mice; # P < 0.05 vs. lonafarnib-treated mice (two-way ANOVA, followed by Tukey’s multiple comparison test). (E) Levels of a7nAChR total proteins in the hippocampus of control and lonafarnib-treated mice treated with vehicle and KN93, and total a7nAChR was normalized by GAPDH, which was again normalized by vehicle-treated group. ** P < 0.01 vs. control mice (two-way ANOVA, followed by Tukey’s multiple comparison test). The expression of protein was normalized by the values of control group with vehicle.
Camkii Inhibitor Kn93, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/camkii inhibitor kn93/product/MedChemExpress
Average 94 stars, based on 1 article reviews
camkii inhibitor kn93 - by Bioz Stars, 2026-02
94/100 stars
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µmol l cyclosporin a  (MedChemExpress)
96
MedChemExpress µmol l cyclosporin a
Lonafarnib administration affects CaMKII signaling pathways, partially modulating the membrane expression of a7nAChR. (A and B) Levels of phospho-PKC and phospho-PKA in the hippocampus of control and lonafarnib-treated mice treated with vehicle, RG108, or anisomycin. (C) Levels of phospho-CaMKII in the hippocampus of control and lonafarnib-treated mice treated with vehicle, RG108, or anisomycin. ** P < 0.01 vs. control mice (two-way ANOVA, followed by Tukey’s multiple comparison test). (D) Levels of biotinylated a7nAChR (membrane) protein in the hippocampus of control and lonafarnib-treated mice treated with vehicle or CaMKII pathway blocker <t>KN93.</t> Surface a7nAChR was normalized by surface GluR2 protein, which was again normalized by vehicle-treated control group. ** P < 0.01 vs. control mice; # P < 0.05 vs. lonafarnib-treated mice (two-way ANOVA, followed by Tukey’s multiple comparison test). (E) Levels of a7nAChR total proteins in the hippocampus of control and lonafarnib-treated mice treated with vehicle and KN93, and total a7nAChR was normalized by GAPDH, which was again normalized by vehicle-treated group. ** P < 0.01 vs. control mice (two-way ANOVA, followed by Tukey’s multiple comparison test). The expression of protein was normalized by the values of control group with vehicle.
µmol L Cyclosporin A, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/µmol l cyclosporin a/product/MedChemExpress
Average 96 stars, based on 1 article reviews
µmol l cyclosporin a - by Bioz Stars, 2026-02
96/100 stars
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Image Search Results


Lonafarnib administration affects CaMKII signaling pathways, partially modulating the membrane expression of a7nAChR. (A and B) Levels of phospho-PKC and phospho-PKA in the hippocampus of control and lonafarnib-treated mice treated with vehicle, RG108, or anisomycin. (C) Levels of phospho-CaMKII in the hippocampus of control and lonafarnib-treated mice treated with vehicle, RG108, or anisomycin. ** P < 0.01 vs. control mice (two-way ANOVA, followed by Tukey’s multiple comparison test). (D) Levels of biotinylated a7nAChR (membrane) protein in the hippocampus of control and lonafarnib-treated mice treated with vehicle or CaMKII pathway blocker KN93. Surface a7nAChR was normalized by surface GluR2 protein, which was again normalized by vehicle-treated control group. ** P < 0.01 vs. control mice; # P < 0.05 vs. lonafarnib-treated mice (two-way ANOVA, followed by Tukey’s multiple comparison test). (E) Levels of a7nAChR total proteins in the hippocampus of control and lonafarnib-treated mice treated with vehicle and KN93, and total a7nAChR was normalized by GAPDH, which was again normalized by vehicle-treated group. ** P < 0.01 vs. control mice (two-way ANOVA, followed by Tukey’s multiple comparison test). The expression of protein was normalized by the values of control group with vehicle.

Journal: Frontiers in Pharmacology

Article Title: Farnesyl Transferase Inhibitor Lonafarnib Enhances α7nAChR Expression Through Inhibiting DNA Methylation of CHRNA7 and Increases α7nAChR Membrane Trafficking

doi: 10.3389/fphar.2020.589780

Figure Lengend Snippet: Lonafarnib administration affects CaMKII signaling pathways, partially modulating the membrane expression of a7nAChR. (A and B) Levels of phospho-PKC and phospho-PKA in the hippocampus of control and lonafarnib-treated mice treated with vehicle, RG108, or anisomycin. (C) Levels of phospho-CaMKII in the hippocampus of control and lonafarnib-treated mice treated with vehicle, RG108, or anisomycin. ** P < 0.01 vs. control mice (two-way ANOVA, followed by Tukey’s multiple comparison test). (D) Levels of biotinylated a7nAChR (membrane) protein in the hippocampus of control and lonafarnib-treated mice treated with vehicle or CaMKII pathway blocker KN93. Surface a7nAChR was normalized by surface GluR2 protein, which was again normalized by vehicle-treated control group. ** P < 0.01 vs. control mice; # P < 0.05 vs. lonafarnib-treated mice (two-way ANOVA, followed by Tukey’s multiple comparison test). (E) Levels of a7nAChR total proteins in the hippocampus of control and lonafarnib-treated mice treated with vehicle and KN93, and total a7nAChR was normalized by GAPDH, which was again normalized by vehicle-treated group. ** P < 0.01 vs. control mice (two-way ANOVA, followed by Tukey’s multiple comparison test). The expression of protein was normalized by the values of control group with vehicle.

Article Snippet: CaMKII inhibitor KN93 and DNMT inhibitor RG108 were purchased from MCE.

Techniques: Protein-Protein interactions, Membrane, Expressing, Control, Comparison

Lonafarnib treatment improves spatial learning memory. (A) Latency (sec) to reach visible platform and hidden platform of Morris water maze in control mice (control), lonafarnib-treated mice (lonafarnib), lonafarnib + KN93-treated mice (lonafarnib + KN93), and lonafarnib + anisomycin-treated mice (lonafarnib + anisomycin). Tracings of typical swim patterns in hidden platform task (upper panels). Black circles indicate the position of platform. * P < 0.05, and ** P < 0.01 vs. control mice, # P < 0.05 vs. Lonafarnib + anisomycin-treated mice, $ P < 0.05 vs. lonafarnib + KN93-treated mice (repeated-measure ANOVA, followed by Tukey’s multiple comparison test). (B) Percentage of swim time (%) in quadrants of platform (PQ), opposite (OQ) and right/left adjacent (R-AQ, L-AQ) in Morris water maze. Tracings of typical swim patterns in probe task (upper panels). ** P < 0.01 and * P < 0.05 vs. swim time in PQ (comparison within group, repeated-measure ANOVA, followed by Dunnett’s multiple comparison test), ## P < 0.01 vs. control mice, + P < 0.05 vs. lonafarnib + KN93-treated mice or + anisomycin-treated mice (one-way ANOVA, followed by Tukey’s multiple comparison test).

Journal: Frontiers in Pharmacology

Article Title: Farnesyl Transferase Inhibitor Lonafarnib Enhances α7nAChR Expression Through Inhibiting DNA Methylation of CHRNA7 and Increases α7nAChR Membrane Trafficking

doi: 10.3389/fphar.2020.589780

Figure Lengend Snippet: Lonafarnib treatment improves spatial learning memory. (A) Latency (sec) to reach visible platform and hidden platform of Morris water maze in control mice (control), lonafarnib-treated mice (lonafarnib), lonafarnib + KN93-treated mice (lonafarnib + KN93), and lonafarnib + anisomycin-treated mice (lonafarnib + anisomycin). Tracings of typical swim patterns in hidden platform task (upper panels). Black circles indicate the position of platform. * P < 0.05, and ** P < 0.01 vs. control mice, # P < 0.05 vs. Lonafarnib + anisomycin-treated mice, $ P < 0.05 vs. lonafarnib + KN93-treated mice (repeated-measure ANOVA, followed by Tukey’s multiple comparison test). (B) Percentage of swim time (%) in quadrants of platform (PQ), opposite (OQ) and right/left adjacent (R-AQ, L-AQ) in Morris water maze. Tracings of typical swim patterns in probe task (upper panels). ** P < 0.01 and * P < 0.05 vs. swim time in PQ (comparison within group, repeated-measure ANOVA, followed by Dunnett’s multiple comparison test), ## P < 0.01 vs. control mice, + P < 0.05 vs. lonafarnib + KN93-treated mice or + anisomycin-treated mice (one-way ANOVA, followed by Tukey’s multiple comparison test).

Article Snippet: CaMKII inhibitor KN93 and DNMT inhibitor RG108 were purchased from MCE.

Techniques: Control, Comparison