HY-153880 Search Results


wu 5  (MedChemExpress)
94
MedChemExpress wu 5
Wu 5, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/wu 5/product/MedChemExpress
Average 94 stars, based on 1 article reviews
wu 5 - by Bioz Stars, 2026-02
94/100 stars
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tazarotene  (MedChemExpress)
91
MedChemExpress tazarotene
Retinoid WYC‐209 is highly potent in inducing tumor cell apoptosis. A) The IC 50 values of conventional drugs (all‐trans retinoic acid (ATRA), <t>tazarotene,</t> or cisplatin) or WYC‐209 for B16‐F1 TRCs were determined in the MTT assay after treatment for 48 h. B,C) B16 TRCs were treated with ATRA, tazarotene, cisplatin at 10 and 100 µ m and WYC‐209 at 10 µ m for 24 h, then the cell apoptotic ratio analyzed by FITC–Annexin‐V and PI apoptosis detection kit. Representative images of flow cytometry data (B) and quantification data of apoptotic cells ratio (C). Apoptotic cells (%) = 100% − (Annexin‐V − PI − )%. D–K) Representative western blot images (D, F, H, J) and quantification (E, G, I, K) of relative γ H2AX, C‐PARP, and C‐Caspase3 expression of B16 TRCs treated with 100 µ m ATRA, 100 µ m tazarotene, 100 µ m cisplatin, or 10 µ m WYC‐209 for various durations. Mean ± s.e.m.; three independent experiments. One‐way ANOVA testing followed by a Tukey post‐hoc test when appropriate was used for statistics. * p < 0.05; ** p < 0.01; *** p < 0.001; ns = not significantly different.
Tazarotene, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/tazarotene/product/MedChemExpress
Average 91 stars, based on 1 article reviews
tazarotene - by Bioz Stars, 2026-02
91/100 stars
  Buy from Supplier

Image Search Results


Retinoid WYC‐209 is highly potent in inducing tumor cell apoptosis. A) The IC 50 values of conventional drugs (all‐trans retinoic acid (ATRA), tazarotene, or cisplatin) or WYC‐209 for B16‐F1 TRCs were determined in the MTT assay after treatment for 48 h. B,C) B16 TRCs were treated with ATRA, tazarotene, cisplatin at 10 and 100 µ m and WYC‐209 at 10 µ m for 24 h, then the cell apoptotic ratio analyzed by FITC–Annexin‐V and PI apoptosis detection kit. Representative images of flow cytometry data (B) and quantification data of apoptotic cells ratio (C). Apoptotic cells (%) = 100% − (Annexin‐V − PI − )%. D–K) Representative western blot images (D, F, H, J) and quantification (E, G, I, K) of relative γ H2AX, C‐PARP, and C‐Caspase3 expression of B16 TRCs treated with 100 µ m ATRA, 100 µ m tazarotene, 100 µ m cisplatin, or 10 µ m WYC‐209 for various durations. Mean ± s.e.m.; three independent experiments. One‐way ANOVA testing followed by a Tukey post‐hoc test when appropriate was used for statistics. * p < 0.05; ** p < 0.01; *** p < 0.001; ns = not significantly different.

Journal: Advanced Science

Article Title: Synthetic Retinoid Kills Drug‐Resistant Cancer Stem Cells via Inducing RAR γ ‐Translocation‐Mediated Tension Reduction and Chromatin Decondensation

doi: 10.1002/advs.202203173

Figure Lengend Snippet: Retinoid WYC‐209 is highly potent in inducing tumor cell apoptosis. A) The IC 50 values of conventional drugs (all‐trans retinoic acid (ATRA), tazarotene, or cisplatin) or WYC‐209 for B16‐F1 TRCs were determined in the MTT assay after treatment for 48 h. B,C) B16 TRCs were treated with ATRA, tazarotene, cisplatin at 10 and 100 µ m and WYC‐209 at 10 µ m for 24 h, then the cell apoptotic ratio analyzed by FITC–Annexin‐V and PI apoptosis detection kit. Representative images of flow cytometry data (B) and quantification data of apoptotic cells ratio (C). Apoptotic cells (%) = 100% − (Annexin‐V − PI − )%. D–K) Representative western blot images (D, F, H, J) and quantification (E, G, I, K) of relative γ H2AX, C‐PARP, and C‐Caspase3 expression of B16 TRCs treated with 100 µ m ATRA, 100 µ m tazarotene, 100 µ m cisplatin, or 10 µ m WYC‐209 for various durations. Mean ± s.e.m.; three independent experiments. One‐way ANOVA testing followed by a Tukey post‐hoc test when appropriate was used for statistics. * p < 0.05; ** p < 0.01; *** p < 0.001; ns = not significantly different.

Article Snippet: Cisplatin (HY‐17394), tazarotene (HY‐15388), and ATRA (HY‐14649) were obtained from MedChem Express (NJ, USA).

Techniques: MTT Assay, Flow Cytometry, Western Blot, Expressing