HY-152878 Search Results


nelfinavir  (MedChemExpress)
93
MedChemExpress nelfinavir
A . Four individual compounds (imiquimod, everolimus, azathioprine, and retinol) and the highest-ranked medication category (anti-HIV protease inhibitors) were tested for their association with a reduced likelihood of a positive SARS-CoV-2 test. In total, 755,346 Veterans were included, and labels on the y-axis indicate the number of individuals who tested positive or negative. For the anti-HIV protease inhibitor category, participants receiving antiretroviral therapy with an anti-HIV protease inhibitor (n=1,105) were compared to those receiving other anti-HIV medications (n=5,450); the relative prescription frequency of anti-HIV protease inhibitors is also provided. The effect size (log(OR)) is plotted with 95% confidence interval (CI) error bars. ***, ** , and * correspond to Bonferroni-adjusted p-values ≤0.001, ≤0.01, and ≤0.05, respectively. B . In vitro anti-SARS-CoV-2 activity was evaluated in ACE2-expressing A549 cells for imiquimod, <t>nelfinavir,</t> saquinavir, everolimus, azathioprine, and retinol (all at 10 μM for 24 hours). The effect on SARS-CoV-2 replication is shown as 2 −ΔΔCt (normalized to 0.01% DMSO vehicle) with 95% CI error bars (n=3). Negative values reflect reduced viral replication. ***, ** , and * correspond to Bonferroni-adjusted p-values ≤0.001, ≤0.01, and ≤0.05, respectively.
Nelfinavir, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/nelfinavir/product/MedChemExpress
Average 93 stars, based on 1 article reviews
nelfinavir - by Bioz Stars, 2026-02
93/100 stars
  Buy from Supplier
nelfinavir mesylate  (MedChemExpress)
94
MedChemExpress nelfinavir mesylate
A . Four individual compounds (imiquimod, everolimus, azathioprine, and retinol) and the highest-ranked medication category (anti-HIV protease inhibitors) were tested for their association with a reduced likelihood of a positive SARS-CoV-2 test. In total, 755,346 Veterans were included, and labels on the y-axis indicate the number of individuals who tested positive or negative. For the anti-HIV protease inhibitor category, participants receiving antiretroviral therapy with an anti-HIV protease inhibitor (n=1,105) were compared to those receiving other anti-HIV medications (n=5,450); the relative prescription frequency of anti-HIV protease inhibitors is also provided. The effect size (log(OR)) is plotted with 95% confidence interval (CI) error bars. ***, ** , and * correspond to Bonferroni-adjusted p-values ≤0.001, ≤0.01, and ≤0.05, respectively. B . In vitro anti-SARS-CoV-2 activity was evaluated in ACE2-expressing A549 cells for imiquimod, <t>nelfinavir,</t> saquinavir, everolimus, azathioprine, and retinol (all at 10 μM for 24 hours). The effect on SARS-CoV-2 replication is shown as 2 −ΔΔCt (normalized to 0.01% DMSO vehicle) with 95% CI error bars (n=3). Negative values reflect reduced viral replication. ***, ** , and * correspond to Bonferroni-adjusted p-values ≤0.001, ≤0.01, and ≤0.05, respectively.
Nelfinavir Mesylate, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/nelfinavir mesylate/product/MedChemExpress
Average 94 stars, based on 1 article reviews
nelfinavir mesylate - by Bioz Stars, 2026-02
94/100 stars
  Buy from Supplier

Image Search Results


A . Four individual compounds (imiquimod, everolimus, azathioprine, and retinol) and the highest-ranked medication category (anti-HIV protease inhibitors) were tested for their association with a reduced likelihood of a positive SARS-CoV-2 test. In total, 755,346 Veterans were included, and labels on the y-axis indicate the number of individuals who tested positive or negative. For the anti-HIV protease inhibitor category, participants receiving antiretroviral therapy with an anti-HIV protease inhibitor (n=1,105) were compared to those receiving other anti-HIV medications (n=5,450); the relative prescription frequency of anti-HIV protease inhibitors is also provided. The effect size (log(OR)) is plotted with 95% confidence interval (CI) error bars. ***, ** , and * correspond to Bonferroni-adjusted p-values ≤0.001, ≤0.01, and ≤0.05, respectively. B . In vitro anti-SARS-CoV-2 activity was evaluated in ACE2-expressing A549 cells for imiquimod, nelfinavir, saquinavir, everolimus, azathioprine, and retinol (all at 10 μM for 24 hours). The effect on SARS-CoV-2 replication is shown as 2 −ΔΔCt (normalized to 0.01% DMSO vehicle) with 95% CI error bars (n=3). Negative values reflect reduced viral replication. ***, ** , and * correspond to Bonferroni-adjusted p-values ≤0.001, ≤0.01, and ≤0.05, respectively.

Journal: medRxiv

Article Title: A genetically based computational drug repurposing framework for rapid identification of candidate compounds: application to COVID-19

doi: 10.1101/2025.01.10.25320348

Figure Lengend Snippet: A . Four individual compounds (imiquimod, everolimus, azathioprine, and retinol) and the highest-ranked medication category (anti-HIV protease inhibitors) were tested for their association with a reduced likelihood of a positive SARS-CoV-2 test. In total, 755,346 Veterans were included, and labels on the y-axis indicate the number of individuals who tested positive or negative. For the anti-HIV protease inhibitor category, participants receiving antiretroviral therapy with an anti-HIV protease inhibitor (n=1,105) were compared to those receiving other anti-HIV medications (n=5,450); the relative prescription frequency of anti-HIV protease inhibitors is also provided. The effect size (log(OR)) is plotted with 95% confidence interval (CI) error bars. ***, ** , and * correspond to Bonferroni-adjusted p-values ≤0.001, ≤0.01, and ≤0.05, respectively. B . In vitro anti-SARS-CoV-2 activity was evaluated in ACE2-expressing A549 cells for imiquimod, nelfinavir, saquinavir, everolimus, azathioprine, and retinol (all at 10 μM for 24 hours). The effect on SARS-CoV-2 replication is shown as 2 −ΔΔCt (normalized to 0.01% DMSO vehicle) with 95% CI error bars (n=3). Negative values reflect reduced viral replication. ***, ** , and * correspond to Bonferroni-adjusted p-values ≤0.001, ≤0.01, and ≤0.05, respectively.

Article Snippet: Imiquimod (Alfa Aesar, Cat # J63990MC), everolimus (Alfa Aesar, Cat # J60139MA), azathioprine (Alfa Aesar, Cat # J6231403), retinol (Alfa Aesar, Cat # J6207903), and the aHIV protease inhibitors; nelfinavir (MCE, Cat # HY-15287) and saquinavir (MCE, Cat # HY-17007) were reconstituted in 100% DMSO.

Techniques: Protease Inhibitor, Medications, In Vitro, Activity Assay, Expressing