HY-148718 Search Results


bmal1 inhibitor stl1267  (MedChemExpress)
94
MedChemExpress bmal1 inhibitor stl1267
Bmal1 Inhibitor Stl1267, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/bmal1 inhibitor stl1267/product/MedChemExpress
Average 94 stars, based on 1 article reviews
bmal1 inhibitor stl1267 - by Bioz Stars, 2026-02
94/100 stars
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potent small molecule sirt 6 activators  (MedChemExpress)
91
MedChemExpress potent small molecule sirt 6 activators
Crystal structures of the 7 human sirtuins . The PDB identifiers for SIRT-1, SIRT-2, SIRT-3, SIRT-5, <t>and</t> <t>SIRT-6</t> are 4KXQ, 4Y6O, 4BN4, 6LJK, and 6HOY, respectively. SIRT-4 and SIRT-7 do not exist in a crystal structure; thus, the AlphaFold-software-predicted structures are shown with the identifiers AF-A0A347ZJG7-F1 and AF-Q9NRC8-F1, respectively.
Potent Small Molecule Sirt 6 Activators, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/potent small molecule sirt 6 activators/product/MedChemExpress
Average 91 stars, based on 1 article reviews
potent small molecule sirt 6 activators - by Bioz Stars, 2026-02
91/100 stars
  Buy from Supplier

Image Search Results


Crystal structures of the 7 human sirtuins . The PDB identifiers for SIRT-1, SIRT-2, SIRT-3, SIRT-5, and SIRT-6 are 4KXQ, 4Y6O, 4BN4, 6LJK, and 6HOY, respectively. SIRT-4 and SIRT-7 do not exist in a crystal structure; thus, the AlphaFold-software-predicted structures are shown with the identifiers AF-A0A347ZJG7-F1 and AF-Q9NRC8-F1, respectively.

Journal: Molecules

Article Title: Virtual Screening in the Identification of Sirtuins’ Activity Modulators

doi: 10.3390/molecules27175641

Figure Lengend Snippet: Crystal structures of the 7 human sirtuins . The PDB identifiers for SIRT-1, SIRT-2, SIRT-3, SIRT-5, and SIRT-6 are 4KXQ, 4Y6O, 4BN4, 6LJK, and 6HOY, respectively. SIRT-4 and SIRT-7 do not exist in a crystal structure; thus, the AlphaFold-software-predicted structures are shown with the identifiers AF-A0A347ZJG7-F1 and AF-Q9NRC8-F1, respectively.

Article Snippet: 2020 , [ ] , Discovery of Potent Small-Molecule SIRT-6 Activators: Structure–Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity , 6 , SBVS , Allosteric site search + docking , Not tested , YES , Specs, ChemDiv, Selleck, and MedChemExpress and in-house database , GOLD software , HIT20 , A , 147.60 (% Peptide Demyristoylation Activation @20 μM).

Techniques: Software

Perspective of the computational studies leading to the identification of selective and/or pan-Sirtuins modulators (shown in green). The chemical structure and the explored biological activity of the discovered hit compounds are reported. The applied virtual screening (VS) strategy is specified as structure-based (SBVS) or ligand-based (LBVS) methodology. The results are listed based on the sirtuin type (alternatively in gray and cyan), according to SBVS followed by LBVS and combined SB-LB approaches, as chronological order. Data about parasitic sirtuins (depicted in coral) are also detailed, referring to the Leishmania (Lm-Sirt), Trypanosoma cruzi (Tc-Sirt) and Schistosoma mansoni (Sm-Sirt) sirtuins.

Journal: Molecules

Article Title: Virtual Screening in the Identification of Sirtuins’ Activity Modulators

doi: 10.3390/molecules27175641

Figure Lengend Snippet: Perspective of the computational studies leading to the identification of selective and/or pan-Sirtuins modulators (shown in green). The chemical structure and the explored biological activity of the discovered hit compounds are reported. The applied virtual screening (VS) strategy is specified as structure-based (SBVS) or ligand-based (LBVS) methodology. The results are listed based on the sirtuin type (alternatively in gray and cyan), according to SBVS followed by LBVS and combined SB-LB approaches, as chronological order. Data about parasitic sirtuins (depicted in coral) are also detailed, referring to the Leishmania (Lm-Sirt), Trypanosoma cruzi (Tc-Sirt) and Schistosoma mansoni (Sm-Sirt) sirtuins.

Article Snippet: 2020 , [ ] , Discovery of Potent Small-Molecule SIRT-6 Activators: Structure–Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity , 6 , SBVS , Allosteric site search + docking , Not tested , YES , Specs, ChemDiv, Selleck, and MedChemExpress and in-house database , GOLD software , HIT20 , A , 147.60 (% Peptide Demyristoylation Activation @20 μM).

Techniques: Activity Assay, Biomarker Discovery, Software, Inhibition, In Silico, Functional Assay, In Vitro, Sequencing, Generated, Histone Deacetylase Assay, Binding Assay, Analogues, Drug discovery, Purification, Modification, Activation Assay, Derivative Assay