HY-147918 Search Results


ibipinabant  (MedChemExpress)
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MedChemExpress ibipinabant
( A ) Structural depiction of prototypical 3-arm and 4-arm CB 1 R antagonists. ( B ) Fluorescent signal of 4-arm modulators <t>ibipinabant,</t> JD5037, MRI-1867, MRI-1891, and MRI-1776 at inhibiting GRAB eCB2.0 basal fluorescence, as determined by averaging ΔF/F 0 between 4 and 5 min. ( C ) Antagonist potency of select 4-arm ligands JD5037, MRI-1867, and MRI-1891 at inhibiting GRAB eCB2.0 fluorescence in presence of 300 nM of CP55940 and in absence of BSA, as determined by averaging ΔF/F 0 normalized between 4 and 5 min. ( D ) Antagonist potency of select 4-arm modulators ibipinabant, JD5037, MRI-1776, MRI-1867, MRI-1891 MRI-1887, MRI-2213, and MRI-2006 (all compounds tested were enantiomerically pure ( S )-isomer) at inhibiting GRAB eCB2.0 fluorescence in presence of 300 nM of CP55940 with 0.5 mg/mL BSA, as determined by averaging ΔF/F 0 normalized between 4 and 5 min. IC 50 values were calculated by GraphPad Prism 9. Data represent mean ± SEM from minimum three independent experiments ( vide infra , ).
Ibipinabant, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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( A ) Structural depiction of prototypical 3-arm and 4-arm CB 1 R antagonists. ( B ) Fluorescent signal of 4-arm modulators ibipinabant, JD5037, MRI-1867, MRI-1891, and MRI-1776 at inhibiting GRAB eCB2.0 basal fluorescence, as determined by averaging ΔF/F 0 between 4 and 5 min. ( C ) Antagonist potency of select 4-arm ligands JD5037, MRI-1867, and MRI-1891 at inhibiting GRAB eCB2.0 fluorescence in presence of 300 nM of CP55940 and in absence of BSA, as determined by averaging ΔF/F 0 normalized between 4 and 5 min. ( D ) Antagonist potency of select 4-arm modulators ibipinabant, JD5037, MRI-1776, MRI-1867, MRI-1891 MRI-1887, MRI-2213, and MRI-2006 (all compounds tested were enantiomerically pure ( S )-isomer) at inhibiting GRAB eCB2.0 fluorescence in presence of 300 nM of CP55940 with 0.5 mg/mL BSA, as determined by averaging ΔF/F 0 normalized between 4 and 5 min. IC 50 values were calculated by GraphPad Prism 9. Data represent mean ± SEM from minimum three independent experiments ( vide infra , ).

Journal: International Journal of Molecular Sciences

Article Title: Pharmacological Evaluation of Cannabinoid Receptor Modulators Using GRAB eCB2.0 Sensor

doi: 10.3390/ijms25095012

Figure Lengend Snippet: ( A ) Structural depiction of prototypical 3-arm and 4-arm CB 1 R antagonists. ( B ) Fluorescent signal of 4-arm modulators ibipinabant, JD5037, MRI-1867, MRI-1891, and MRI-1776 at inhibiting GRAB eCB2.0 basal fluorescence, as determined by averaging ΔF/F 0 between 4 and 5 min. ( C ) Antagonist potency of select 4-arm ligands JD5037, MRI-1867, and MRI-1891 at inhibiting GRAB eCB2.0 fluorescence in presence of 300 nM of CP55940 and in absence of BSA, as determined by averaging ΔF/F 0 normalized between 4 and 5 min. ( D ) Antagonist potency of select 4-arm modulators ibipinabant, JD5037, MRI-1776, MRI-1867, MRI-1891 MRI-1887, MRI-2213, and MRI-2006 (all compounds tested were enantiomerically pure ( S )-isomer) at inhibiting GRAB eCB2.0 fluorescence in presence of 300 nM of CP55940 with 0.5 mg/mL BSA, as determined by averaging ΔF/F 0 normalized between 4 and 5 min. IC 50 values were calculated by GraphPad Prism 9. Data represent mean ± SEM from minimum three independent experiments ( vide infra , ).

Article Snippet: Chemicals and Reagents: 2-AG (Cayman, Ann Arbor, MI, USA #62160), CP55940 (Cayman #13608), ACEA (Biotechne, Minneapolis, MN, USA: Tocris #1319), SR141716 (MedChem Express, New York, NY, USA: #HY14136), Taranabant (MedChem Express #HY10013), Otenabant (MedChem Express #HY-10871), Ibipinabant (MedChem Express HY-14791), and GAT228 and GAT229 (MilliporeSigma: Burlington, MA, USA #SML1952 and #SML1951).

Techniques: Fluorescence