HY-145879 Search Results


nrf2 activator 2  (MedChemExpress)
94
MedChemExpress nrf2 activator 2
miR-141-3p promotes OC proliferation and M2 polarization via <t>Keap1/Nrf2</t> pathway. (a) The miR-141-3p mimic promotes the proliferation of SKOV3 cells, while the promotional effect of miR-141-3p was abolished by Nrf2 inhibitor ML3508; (b) miR-141-3p mimic increases expression of M2-like macrophage biomarker CD206 and this effect is abolished by Nrf2 inhibitor; (c–f) The increasing mRNA levels of Arg1 and IL-10, and decreasing mRNA levels of iNOS and TNF-α caused by miR-141-3p mimic are reversed by Nrf2 inhibitor ML3508; (g) The protein levels of Keap1 and Nrf2 in SKOV3 cells after being treated by miR-141-3p NC, miR-141-3p mimic, and miR-141-3p mimic + ML3508.
Nrf2 Activator 2, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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miR-141-3p promotes OC proliferation and M2 polarization via Keap1/Nrf2 pathway. (a) The miR-141-3p mimic promotes the proliferation of SKOV3 cells, while the promotional effect of miR-141-3p was abolished by Nrf2 inhibitor ML3508; (b) miR-141-3p mimic increases expression of M2-like macrophage biomarker CD206 and this effect is abolished by Nrf2 inhibitor; (c–f) The increasing mRNA levels of Arg1 and IL-10, and decreasing mRNA levels of iNOS and TNF-α caused by miR-141-3p mimic are reversed by Nrf2 inhibitor ML3508; (g) The protein levels of Keap1 and Nrf2 in SKOV3 cells after being treated by miR-141-3p NC, miR-141-3p mimic, and miR-141-3p mimic + ML3508.

Journal: Open Medicine

Article Title: miR-141-3p accelerates ovarian cancer progression and promotes M2-like macrophage polarization by targeting the Keap1-Nrf2 pathway

doi: 10.1515/med-2023-0729

Figure Lengend Snippet: miR-141-3p promotes OC proliferation and M2 polarization via Keap1/Nrf2 pathway. (a) The miR-141-3p mimic promotes the proliferation of SKOV3 cells, while the promotional effect of miR-141-3p was abolished by Nrf2 inhibitor ML3508; (b) miR-141-3p mimic increases expression of M2-like macrophage biomarker CD206 and this effect is abolished by Nrf2 inhibitor; (c–f) The increasing mRNA levels of Arg1 and IL-10, and decreasing mRNA levels of iNOS and TNF-α caused by miR-141-3p mimic are reversed by Nrf2 inhibitor ML3508; (g) The protein levels of Keap1 and Nrf2 in SKOV3 cells after being treated by miR-141-3p NC, miR-141-3p mimic, and miR-141-3p mimic + ML3508.

Article Snippet: Nrf2 activator-2 (compound O15, HY-145879) was purchased from Med chem express (MCE, CA, USA), and this compound (5.0 μM) was added into the cell culture medium of SKOV3 followed by miR-141-3p inhibitor treatment.

Techniques: Expressing, Biomarker Assay