HY-145869 Search Results


irosustat  (MedChemExpress)
94
MedChemExpress irosustat
( A to H ) Percent αSMA reduction in male VICs (blue) and female VICs (red) cultured on TCPS with indicated doses of (A) Y-27632, (B) LY294002, (C) H1152, (D) SB203580, (E) <t>irosustat,</t> (F) TM5441, (G) losartan, and (H) SD-208. ( I ) Heatmap showing the log ratio of male EC 20 to female EC 20 for each inhibitor. Data are plotted as means ± SEM ( N = 3 biological replicates). The best fit line shown was generated using a nonlinear regression curve fit with GraphPad Prism. Statistical significance was determined by an unpaired two-tailed t test with Welch’s correction and indicated as * P < 0.05 (Y-27632 and losartan showed a significant difference in efficacy between male and female VICs).
Irosustat, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/irosustat/product/MedChemExpress
Average 94 stars, based on 1 article reviews
irosustat - by Bioz Stars, 2026-02
94/100 stars
  Buy from Supplier

Image Search Results


( A to H ) Percent αSMA reduction in male VICs (blue) and female VICs (red) cultured on TCPS with indicated doses of (A) Y-27632, (B) LY294002, (C) H1152, (D) SB203580, (E) irosustat, (F) TM5441, (G) losartan, and (H) SD-208. ( I ) Heatmap showing the log ratio of male EC 20 to female EC 20 for each inhibitor. Data are plotted as means ± SEM ( N = 3 biological replicates). The best fit line shown was generated using a nonlinear regression curve fit with GraphPad Prism. Statistical significance was determined by an unpaired two-tailed t test with Welch’s correction and indicated as * P < 0.05 (Y-27632 and losartan showed a significant difference in efficacy between male and female VICs).

Journal: Science Advances

Article Title: Determining sex differences in aortic valve myofibroblast responses to drug combinations identified using a digital medicine platform

doi: 10.1126/sciadv.adu2695

Figure Lengend Snippet: ( A to H ) Percent αSMA reduction in male VICs (blue) and female VICs (red) cultured on TCPS with indicated doses of (A) Y-27632, (B) LY294002, (C) H1152, (D) SB203580, (E) irosustat, (F) TM5441, (G) losartan, and (H) SD-208. ( I ) Heatmap showing the log ratio of male EC 20 to female EC 20 for each inhibitor. Data are plotted as means ± SEM ( N = 3 biological replicates). The best fit line shown was generated using a nonlinear regression curve fit with GraphPad Prism. Statistical significance was determined by an unpaired two-tailed t test with Welch’s correction and indicated as * P < 0.05 (Y-27632 and losartan showed a significant difference in efficacy between male and female VICs).

Article Snippet: Lyophilized drug powders were resuspended with sterile filtered deionized water [H-1152 (Tocris) and Y-27632 (Tocris)] or sterile DMSO [LY-294002 (Cell Signaling Technology), SB203580 (Selleck Chemicals), Irosustat (Selleck Chemicals), TM-5441 (MedChemExpress), SD-208 (Sigma-Aldrich), losartan (Selleck Chemicals), ibrutinib (Selleck Chemicals), bosentan (Sigma-Aldrich), and KDOAM-25 (MedChemExpress)].

Techniques: Cell Culture, Generated, Two Tailed Test

( A to H ) Percent αSMA reduction in male VICs (blue) and female VICs (red) cultured on stiff hydrogels with indicated doses of (A) Y-27632, (B) LY294002, (C) H1152, (D) SB203580, (E) irosustat, (F) TM5441, (G) losartan, and (H) SD-208. ( I ) Heatmap showing the log ratio of male EC 20 to female EC 20 for each inhibitor. Data are plotted as means ± SEM ( N = 3 biological replicates). The best fit line shown was generated using a nonlinear regression curve fit with GraphPad Prism. Statistical significance was determined by an unpaired two-tailed t test with Welch’s correction and indicated as * P < 0.05 (losartan showed a significant difference in efficacy between male and female VICs).

Journal: Science Advances

Article Title: Determining sex differences in aortic valve myofibroblast responses to drug combinations identified using a digital medicine platform

doi: 10.1126/sciadv.adu2695

Figure Lengend Snippet: ( A to H ) Percent αSMA reduction in male VICs (blue) and female VICs (red) cultured on stiff hydrogels with indicated doses of (A) Y-27632, (B) LY294002, (C) H1152, (D) SB203580, (E) irosustat, (F) TM5441, (G) losartan, and (H) SD-208. ( I ) Heatmap showing the log ratio of male EC 20 to female EC 20 for each inhibitor. Data are plotted as means ± SEM ( N = 3 biological replicates). The best fit line shown was generated using a nonlinear regression curve fit with GraphPad Prism. Statistical significance was determined by an unpaired two-tailed t test with Welch’s correction and indicated as * P < 0.05 (losartan showed a significant difference in efficacy between male and female VICs).

Article Snippet: Lyophilized drug powders were resuspended with sterile filtered deionized water [H-1152 (Tocris) and Y-27632 (Tocris)] or sterile DMSO [LY-294002 (Cell Signaling Technology), SB203580 (Selleck Chemicals), Irosustat (Selleck Chemicals), TM-5441 (MedChemExpress), SD-208 (Sigma-Aldrich), losartan (Selleck Chemicals), ibrutinib (Selleck Chemicals), bosentan (Sigma-Aldrich), and KDOAM-25 (MedChemExpress)].

Techniques: Cell Culture, Generated, Two Tailed Test

( A ) Percent αSMA reduction in male VICs cultured with IDentif.AI-designed effective (green) and ineffective (red) drug combinations. (1) indicates L1 dose and (2) indicates L2 dose of that drug ( n = 3 to 4). The percent αSMA reduction for monotherapies at L1/L2 doses is summarized in table S6. ( B ) Correlation plot between the predicted versus measured percent αSMA reduction for IDentif.AI-designed combinations. ( C ) Validation of top three and bottom ranked IDentif.AI drug combinations ( N = 3). ( D ) Representative immunofluorescent images with αSMA stained in green and DAPI stained in blue. Scale bars, 100 μm. ( E ) Interaction map of Losartan and SD-208 at various dose ratios and their respective percent αSMA reduction ( N = 3). ( F ) Synergy map of losartan and SD-208 at various dose ratios ( N = 3). The black box indicates the therapeutic dosing range (0 - L2) used for IDentif.AI analysis. Statistical significance was determined by a one-sample t test against a theoretical mean of zero to represent the vehicle control and indicated as * P < 0.05, ** P < 0.01, and *** P < 0.001. Bliss synergy scores of <−10, between −10 and 10, and >10 represent antagonistic, additive, and synergistic drug interactions. Data are plotted as means ± SD. H1152, H11; irosustat, Iro; losartan, Los; LY294002, LY; SB203580, SB; SD-208, SD; TM5441, TM; Y-27632, Y27. N = number of biological replicates. n = number of gels. ns, not significant.

Journal: Science Advances

Article Title: Determining sex differences in aortic valve myofibroblast responses to drug combinations identified using a digital medicine platform

doi: 10.1126/sciadv.adu2695

Figure Lengend Snippet: ( A ) Percent αSMA reduction in male VICs cultured with IDentif.AI-designed effective (green) and ineffective (red) drug combinations. (1) indicates L1 dose and (2) indicates L2 dose of that drug ( n = 3 to 4). The percent αSMA reduction for monotherapies at L1/L2 doses is summarized in table S6. ( B ) Correlation plot between the predicted versus measured percent αSMA reduction for IDentif.AI-designed combinations. ( C ) Validation of top three and bottom ranked IDentif.AI drug combinations ( N = 3). ( D ) Representative immunofluorescent images with αSMA stained in green and DAPI stained in blue. Scale bars, 100 μm. ( E ) Interaction map of Losartan and SD-208 at various dose ratios and their respective percent αSMA reduction ( N = 3). ( F ) Synergy map of losartan and SD-208 at various dose ratios ( N = 3). The black box indicates the therapeutic dosing range (0 - L2) used for IDentif.AI analysis. Statistical significance was determined by a one-sample t test against a theoretical mean of zero to represent the vehicle control and indicated as * P < 0.05, ** P < 0.01, and *** P < 0.001. Bliss synergy scores of <−10, between −10 and 10, and >10 represent antagonistic, additive, and synergistic drug interactions. Data are plotted as means ± SD. H1152, H11; irosustat, Iro; losartan, Los; LY294002, LY; SB203580, SB; SD-208, SD; TM5441, TM; Y-27632, Y27. N = number of biological replicates. n = number of gels. ns, not significant.

Article Snippet: Lyophilized drug powders were resuspended with sterile filtered deionized water [H-1152 (Tocris) and Y-27632 (Tocris)] or sterile DMSO [LY-294002 (Cell Signaling Technology), SB203580 (Selleck Chemicals), Irosustat (Selleck Chemicals), TM-5441 (MedChemExpress), SD-208 (Sigma-Aldrich), losartan (Selleck Chemicals), ibrutinib (Selleck Chemicals), bosentan (Sigma-Aldrich), and KDOAM-25 (MedChemExpress)].

Techniques: Cell Culture, Biomarker Discovery, Staining, Control