HY-144446 Search Results


plinabulin  (MedChemExpress)
94
MedChemExpress plinabulin
<t>Plinabulin</t> washes out faster from cells than other microtubule destabilizers. HPMECs were incubated with 100 nM of each drug at time 0, followed by four sequential washes at 3, 4, 6, and 9 hours. Cells were harvested at 0, 1, and 6 hours post-initial wash, and intracellular drug concentrations were measured using LC-MS. Drug concentrations are presented as absolute intracellular concentrations (left) and normalized to their initial values (right).
Plinabulin, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Plinabulin washes out faster from cells than other microtubule destabilizers. HPMECs were incubated with 100 nM of each drug at time 0, followed by four sequential washes at 3, 4, 6, and 9 hours. Cells were harvested at 0, 1, and 6 hours post-initial wash, and intracellular drug concentrations were measured using LC-MS. Drug concentrations are presented as absolute intracellular concentrations (left) and normalized to their initial values (right).

Journal: bioRxiv

Article Title: Diverse microtubule-destabilizing drugs induce equivalent molecular pathway responses in endothelial cells

doi: 10.1101/2025.01.22.632572

Figure Lengend Snippet: Plinabulin washes out faster from cells than other microtubule destabilizers. HPMECs were incubated with 100 nM of each drug at time 0, followed by four sequential washes at 3, 4, 6, and 9 hours. Cells were harvested at 0, 1, and 6 hours post-initial wash, and intracellular drug concentrations were measured using LC-MS. Drug concentrations are presented as absolute intracellular concentrations (left) and normalized to their initial values (right).

Article Snippet: Microtubule perturbing agents combretastatin-A4 (CA4, MedChemExpress #HY-N2146), vinblastine sulfate (VB, MedChemExpress #HY-13780), plinabulin (PL, MedChemExpress #HY-14444), and docetaxel (DTXL, MedChemExpress #HY-B0011) were reconstituted as 10 mM stocks in 100% DMSO.

Techniques: Incubation, Liquid Chromatography with Mass Spectroscopy