HY-13948B Search Results


angiotensin ii  (MedChemExpress)
96
MedChemExpress angiotensin ii
Comparison of blood lipid levels, MAP, TLR2 and expressions of inflammatory factors, and changes of gene expression in each group. (a) Comparison of blood lipid levels: the concentration of TC and LDL in serum was lower in high fat-Ang II group and high-fat group than that in the control group, and the difference in the concentration of triglyceride and HDL was not statistically significant compared to the control group. (b) Comparison of MAP levels in each group: high fat-Ang II group had significantly higher MAP than high-fat group after the construction of the model, and in the meantime, MAP in the two groups was significantly higher than that in the control group. (c) Comparison of TLR2 and proinflammatory factor levels in serum of each group: TLR2 and proinflammatory factor levels were significantly higher in high-fat group than those in the control group, and TLR2 and IL-1 β , IL-6, TNF- α , and CCL2 levels did not significantly increase compared to the control group, while CCL2 levels were not statistically significant compared to the control groups. (d) Heat map of gene expression abundance detected by qPCR showed significantly lower genes related to fatty acid oxidation, fatty hydrolysis, and cholesterolosis in high fat-Ang II group and high-fat group compared with the control groups ( n = 5; ∗∗∗ P < 0.001).
Angiotensin Ii, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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angiotensin ii human acetate  (MedChemExpress)
93
MedChemExpress angiotensin ii human acetate
Comparison of blood lipid levels, MAP, TLR2 and expressions of inflammatory factors, and changes of gene expression in each group. (a) Comparison of blood lipid levels: the concentration of TC and LDL in serum was lower in high fat-Ang II group and high-fat group than that in the control group, and the difference in the concentration of triglyceride and HDL was not statistically significant compared to the control group. (b) Comparison of MAP levels in each group: high fat-Ang II group had significantly higher MAP than high-fat group after the construction of the model, and in the meantime, MAP in the two groups was significantly higher than that in the control group. (c) Comparison of TLR2 and proinflammatory factor levels in serum of each group: TLR2 and proinflammatory factor levels were significantly higher in high-fat group than those in the control group, and TLR2 and IL-1 β , IL-6, TNF- α , and CCL2 levels did not significantly increase compared to the control group, while CCL2 levels were not statistically significant compared to the control groups. (d) Heat map of gene expression abundance detected by qPCR showed significantly lower genes related to fatty acid oxidation, fatty hydrolysis, and cholesterolosis in high fat-Ang II group and high-fat group compared with the control groups ( n = 5; ∗∗∗ P < 0.001).
Angiotensin Ii Human Acetate, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
angiotensin ii human acetate - by Bioz Stars, 2026-02
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tl 895  (MedChemExpress)
93
MedChemExpress tl 895
Comparison of blood lipid levels, MAP, TLR2 and expressions of inflammatory factors, and changes of gene expression in each group. (a) Comparison of blood lipid levels: the concentration of TC and LDL in serum was lower in high fat-Ang II group and high-fat group than that in the control group, and the difference in the concentration of triglyceride and HDL was not statistically significant compared to the control group. (b) Comparison of MAP levels in each group: high fat-Ang II group had significantly higher MAP than high-fat group after the construction of the model, and in the meantime, MAP in the two groups was significantly higher than that in the control group. (c) Comparison of TLR2 and proinflammatory factor levels in serum of each group: TLR2 and proinflammatory factor levels were significantly higher in high-fat group than those in the control group, and TLR2 and IL-1 β , IL-6, TNF- α , and CCL2 levels did not significantly increase compared to the control group, while CCL2 levels were not statistically significant compared to the control groups. (d) Heat map of gene expression abundance detected by qPCR showed significantly lower genes related to fatty acid oxidation, fatty hydrolysis, and cholesterolosis in high fat-Ang II group and high-fat group compared with the control groups ( n = 5; ∗∗∗ P < 0.001).
Tl 895, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/tl 895/product/MedChemExpress
Average 93 stars, based on 1 article reviews
tl 895 - by Bioz Stars, 2026-02
93/100 stars
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angiotensin ii human  (MedChemExpress)
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Image Search Results


Comparison of blood lipid levels, MAP, TLR2 and expressions of inflammatory factors, and changes of gene expression in each group. (a) Comparison of blood lipid levels: the concentration of TC and LDL in serum was lower in high fat-Ang II group and high-fat group than that in the control group, and the difference in the concentration of triglyceride and HDL was not statistically significant compared to the control group. (b) Comparison of MAP levels in each group: high fat-Ang II group had significantly higher MAP than high-fat group after the construction of the model, and in the meantime, MAP in the two groups was significantly higher than that in the control group. (c) Comparison of TLR2 and proinflammatory factor levels in serum of each group: TLR2 and proinflammatory factor levels were significantly higher in high-fat group than those in the control group, and TLR2 and IL-1 β , IL-6, TNF- α , and CCL2 levels did not significantly increase compared to the control group, while CCL2 levels were not statistically significant compared to the control groups. (d) Heat map of gene expression abundance detected by qPCR showed significantly lower genes related to fatty acid oxidation, fatty hydrolysis, and cholesterolosis in high fat-Ang II group and high-fat group compared with the control groups ( n = 5; ∗∗∗ P < 0.001).

Journal: Journal of Healthcare Engineering

Article Title: Study on Toll-Like Receptor 2-Mediated Inflammation-Induced Familial Hypertension Combined with Hyperlipemia and Its Mechanism

doi: 10.1155/2022/1473597

Figure Lengend Snippet: Comparison of blood lipid levels, MAP, TLR2 and expressions of inflammatory factors, and changes of gene expression in each group. (a) Comparison of blood lipid levels: the concentration of TC and LDL in serum was lower in high fat-Ang II group and high-fat group than that in the control group, and the difference in the concentration of triglyceride and HDL was not statistically significant compared to the control group. (b) Comparison of MAP levels in each group: high fat-Ang II group had significantly higher MAP than high-fat group after the construction of the model, and in the meantime, MAP in the two groups was significantly higher than that in the control group. (c) Comparison of TLR2 and proinflammatory factor levels in serum of each group: TLR2 and proinflammatory factor levels were significantly higher in high-fat group than those in the control group, and TLR2 and IL-1 β , IL-6, TNF- α , and CCL2 levels did not significantly increase compared to the control group, while CCL2 levels were not statistically significant compared to the control groups. (d) Heat map of gene expression abundance detected by qPCR showed significantly lower genes related to fatty acid oxidation, fatty hydrolysis, and cholesterolosis in high fat-Ang II group and high-fat group compared with the control groups ( n = 5; ∗∗∗ P < 0.001).

Article Snippet: Angiotensin II (Ang II, MCE, 4474-91-3) was dissolved into dimethyl sulfoxide (DMSO, 10%) and corn oil (10%) successively into 5.23 mg/ml (5 mM) mother solution, which was poured into Alzet-implanted administration pump (US Alzet, 2006 micropump) capsule.

Techniques: Comparison, Expressing, Concentration Assay, Control

Changes of MAP, blood lipid levels, TLR2 in serum and inflammatory factor concentrations, and lipid metabolism-related gene expression between Tlr2 -/- -high fat-Ang II group and wild-high lipid-Ang II groups. (a) Comparison of MAP in Tlr2 -/- -high fat-Ang II group and wild-high fat-Ang II group, MAP after the construction of the model was significantly lower in the Tlr2 -/- -high fat-Ang II group than that in the wild-high fat-Ang II group. (b) Comparison of lipids and apolipoproteins in serum in Tlr2 -/- -high fat-Ang II group and wild-high fat-Ang II group, TC and LDL in serum significantly decreased in the Tlr2 -/- -high fat-Ang II group compared to the wild-high fat-Ang II group, while there was no significantly statistical difference between triglyceride and HDL between the two groups. (c) Tlr2 -/- -high fat-Ang II group was not detected TLR2 in serum; at the same time, the levels of IL-1 β and TNF- α were significantly lower than those in wild-high fat-Ang II group, with no statistical difference in IL-6 and CCL2 concentrations in serum than those in the wild-high fat-Ang II group. (d) Heat map of gene expression abundance detected by qPCR showed significantly increased related gene expressions of fatty acid oxidation, fat hydrolysis, and cholesterol hydrolysis in the Tlr2 -/- -high fat-Ang II group compared to the wild-high fat-Ang II group ( n = 5; ∗∗∗ P < 0.001).

Journal: Journal of Healthcare Engineering

Article Title: Study on Toll-Like Receptor 2-Mediated Inflammation-Induced Familial Hypertension Combined with Hyperlipemia and Its Mechanism

doi: 10.1155/2022/1473597

Figure Lengend Snippet: Changes of MAP, blood lipid levels, TLR2 in serum and inflammatory factor concentrations, and lipid metabolism-related gene expression between Tlr2 -/- -high fat-Ang II group and wild-high lipid-Ang II groups. (a) Comparison of MAP in Tlr2 -/- -high fat-Ang II group and wild-high fat-Ang II group, MAP after the construction of the model was significantly lower in the Tlr2 -/- -high fat-Ang II group than that in the wild-high fat-Ang II group. (b) Comparison of lipids and apolipoproteins in serum in Tlr2 -/- -high fat-Ang II group and wild-high fat-Ang II group, TC and LDL in serum significantly decreased in the Tlr2 -/- -high fat-Ang II group compared to the wild-high fat-Ang II group, while there was no significantly statistical difference between triglyceride and HDL between the two groups. (c) Tlr2 -/- -high fat-Ang II group was not detected TLR2 in serum; at the same time, the levels of IL-1 β and TNF- α were significantly lower than those in wild-high fat-Ang II group, with no statistical difference in IL-6 and CCL2 concentrations in serum than those in the wild-high fat-Ang II group. (d) Heat map of gene expression abundance detected by qPCR showed significantly increased related gene expressions of fatty acid oxidation, fat hydrolysis, and cholesterol hydrolysis in the Tlr2 -/- -high fat-Ang II group compared to the wild-high fat-Ang II group ( n = 5; ∗∗∗ P < 0.001).

Article Snippet: Angiotensin II (Ang II, MCE, 4474-91-3) was dissolved into dimethyl sulfoxide (DMSO, 10%) and corn oil (10%) successively into 5.23 mg/ml (5 mM) mother solution, which was poured into Alzet-implanted administration pump (US Alzet, 2006 micropump) capsule.

Techniques: Expressing, Comparison

Changes of Akt pathway protein, MAP, lipid level, and apolipoprotein level, TLR2 and inflammatory factors compared those after blocking the Akt pathway. (a) The expression of p-Akt, t-Akt proteins in the wild-high fat-Ang II-CCT128930 group was significantly lower than that in wild-high fat-Ang II group. (b) After the construction of the model, MAP in the wild-high fat-Ang II-CCT128930 group significantly decreased compared with that in the wild-high fat-Ang II group. (c) The TC and LDL in serum decreased significantly in wild-high fat-Ang II-CCT128930 group and wild-high fat-Ang II group compared with those in the wild-high fat-Ang II group, but there was no significantly statistical difference in triglyceride and HDL between the two groups. (d) Comparison of serum levels of TLR2 and proinflammatory factor in each group. The concentration of IL-1 β , TNF- α , and CCL2 in serum significantly decreased in the wild-high fat-Ang II-CCT128930 group compared with that in the wild-high fat-Ang II group, with no statistical difference in the concentration of TLR2 and IL-6 ( n = 5; ∗∗∗ P < 0.001).

Journal: Journal of Healthcare Engineering

Article Title: Study on Toll-Like Receptor 2-Mediated Inflammation-Induced Familial Hypertension Combined with Hyperlipemia and Its Mechanism

doi: 10.1155/2022/1473597

Figure Lengend Snippet: Changes of Akt pathway protein, MAP, lipid level, and apolipoprotein level, TLR2 and inflammatory factors compared those after blocking the Akt pathway. (a) The expression of p-Akt, t-Akt proteins in the wild-high fat-Ang II-CCT128930 group was significantly lower than that in wild-high fat-Ang II group. (b) After the construction of the model, MAP in the wild-high fat-Ang II-CCT128930 group significantly decreased compared with that in the wild-high fat-Ang II group. (c) The TC and LDL in serum decreased significantly in wild-high fat-Ang II-CCT128930 group and wild-high fat-Ang II group compared with those in the wild-high fat-Ang II group, but there was no significantly statistical difference in triglyceride and HDL between the two groups. (d) Comparison of serum levels of TLR2 and proinflammatory factor in each group. The concentration of IL-1 β , TNF- α , and CCL2 in serum significantly decreased in the wild-high fat-Ang II-CCT128930 group compared with that in the wild-high fat-Ang II group, with no statistical difference in the concentration of TLR2 and IL-6 ( n = 5; ∗∗∗ P < 0.001).

Article Snippet: Angiotensin II (Ang II, MCE, 4474-91-3) was dissolved into dimethyl sulfoxide (DMSO, 10%) and corn oil (10%) successively into 5.23 mg/ml (5 mM) mother solution, which was poured into Alzet-implanted administration pump (US Alzet, 2006 micropump) capsule.

Techniques: Blocking Assay, Expressing, Comparison, Concentration Assay

Changes in NF- κ B pathway protein, MAP, lipid level, and apolipoprotein levels, TLR2, and inflammatory factors after blocking the NF- κ B pathway. (a) IKK and protein expression levels of the wild-high fat-Ang II-BAY11-7082 group were significantly lower than those of the wild-high fat-Ang II group. (b) MAP in the wild-high fat-Ang II-BAY11-7082 group significantly decreased compared with the wild-high fat-Ang II group. (c) The TC and LDL in serum significantly decreased in the wild-high fat-Ang II group and wild-high fat-Ang II group, with no significant statistical difference between triglyceride and high-density lipoprotein in the two groups. (d) The concentrations of IL-1 β and TNF- α in serum significantly decreased in the wild-high fat-Ang II-BAY11-7082 group compared with the wild-high fat-Ang II group, with no statistical difference in the concentrations of TLR2, IL-6, and CCL2 ( n = 5; ∗∗∗ P < 0.001).

Journal: Journal of Healthcare Engineering

Article Title: Study on Toll-Like Receptor 2-Mediated Inflammation-Induced Familial Hypertension Combined with Hyperlipemia and Its Mechanism

doi: 10.1155/2022/1473597

Figure Lengend Snippet: Changes in NF- κ B pathway protein, MAP, lipid level, and apolipoprotein levels, TLR2, and inflammatory factors after blocking the NF- κ B pathway. (a) IKK and protein expression levels of the wild-high fat-Ang II-BAY11-7082 group were significantly lower than those of the wild-high fat-Ang II group. (b) MAP in the wild-high fat-Ang II-BAY11-7082 group significantly decreased compared with the wild-high fat-Ang II group. (c) The TC and LDL in serum significantly decreased in the wild-high fat-Ang II group and wild-high fat-Ang II group, with no significant statistical difference between triglyceride and high-density lipoprotein in the two groups. (d) The concentrations of IL-1 β and TNF- α in serum significantly decreased in the wild-high fat-Ang II-BAY11-7082 group compared with the wild-high fat-Ang II group, with no statistical difference in the concentrations of TLR2, IL-6, and CCL2 ( n = 5; ∗∗∗ P < 0.001).

Article Snippet: Angiotensin II (Ang II, MCE, 4474-91-3) was dissolved into dimethyl sulfoxide (DMSO, 10%) and corn oil (10%) successively into 5.23 mg/ml (5 mM) mother solution, which was poured into Alzet-implanted administration pump (US Alzet, 2006 micropump) capsule.

Techniques: Blocking Assay, Expressing