HY-137887 Search Results


htr1f agonist ly344864  (MedChemExpress)
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MedChemExpress htr1f agonist ly344864
A Paradigm for treatment of mice with <t>HTR1F</t> agonist <t>LY344864</t> or Let-7 antagonist (antisense oligonucleotide [ASO]) and subsequent administration of PTZ to characterize seizure responses. Created in BioRender. Schoch, K. (2025) https://biorender.com/y53fyfl . B Mice were treated with HTR1F agonist or dimethyl sulfoxide (DMSO) vehicle for 3 days at P28 by daily intraperitoneal injection and responses to seizure induction were characterized. Seizure scores were plotted between control treatment versus LY344864 ( n = 12,12; two-tailed Mann–Whitney p = 0.5466). Cumulative distribution demonstrating time in seconds between administration of PTZ and onset of C first response ( n = 12, 12; 2-way ANOVA; p = 0.06), D score 3 ( n = 11,12), E or score 5 ( n = 10, 11; p = 0.02). Source data are provided as a Source Data file. F Female mice were treated with Let-7 ASO or scramble ASO control for 4 weeks from 3 months of age by intracerebroventricular injection, and responses to seizure induction were characterized. Seizure scores were plotted between scramble ASO sequence and Let-7 ASO ( n = 12,12; two-tailed Mann–Whitney p = 0.0474). G – I Survival curves demonstrating time in seconds between administration of PTZ and onset of G first response ( n = 12, 12; 2-way ANOVA, p = 0.003), H score 3 ( n = 11, 12; p = 0.06), I or score 5 ( n = 6,10). Error bars in ( B , F ) represent SEM.
Htr1f Agonist Ly344864, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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A Paradigm for treatment of mice with HTR1F agonist LY344864 or Let-7 antagonist (antisense oligonucleotide [ASO]) and subsequent administration of PTZ to characterize seizure responses. Created in BioRender. Schoch, K. (2025) https://biorender.com/y53fyfl . B Mice were treated with HTR1F agonist or dimethyl sulfoxide (DMSO) vehicle for 3 days at P28 by daily intraperitoneal injection and responses to seizure induction were characterized. Seizure scores were plotted between control treatment versus LY344864 ( n = 12,12; two-tailed Mann–Whitney p = 0.5466). Cumulative distribution demonstrating time in seconds between administration of PTZ and onset of C first response ( n = 12, 12; 2-way ANOVA; p = 0.06), D score 3 ( n = 11,12), E or score 5 ( n = 10, 11; p = 0.02). Source data are provided as a Source Data file. F Female mice were treated with Let-7 ASO or scramble ASO control for 4 weeks from 3 months of age by intracerebroventricular injection, and responses to seizure induction were characterized. Seizure scores were plotted between scramble ASO sequence and Let-7 ASO ( n = 12,12; two-tailed Mann–Whitney p = 0.0474). G – I Survival curves demonstrating time in seconds between administration of PTZ and onset of G first response ( n = 12, 12; 2-way ANOVA, p = 0.003), H score 3 ( n = 11, 12; p = 0.06), I or score 5 ( n = 6,10). Error bars in ( B , F ) represent SEM.

Journal: Nature Communications

Article Title: Antecedent enhancer activity predicts future susceptibility to seizures in mice

doi: 10.1038/s41467-025-65346-2

Figure Lengend Snippet: A Paradigm for treatment of mice with HTR1F agonist LY344864 or Let-7 antagonist (antisense oligonucleotide [ASO]) and subsequent administration of PTZ to characterize seizure responses. Created in BioRender. Schoch, K. (2025) https://biorender.com/y53fyfl . B Mice were treated with HTR1F agonist or dimethyl sulfoxide (DMSO) vehicle for 3 days at P28 by daily intraperitoneal injection and responses to seizure induction were characterized. Seizure scores were plotted between control treatment versus LY344864 ( n = 12,12; two-tailed Mann–Whitney p = 0.5466). Cumulative distribution demonstrating time in seconds between administration of PTZ and onset of C first response ( n = 12, 12; 2-way ANOVA; p = 0.06), D score 3 ( n = 11,12), E or score 5 ( n = 10, 11; p = 0.02). Source data are provided as a Source Data file. F Female mice were treated with Let-7 ASO or scramble ASO control for 4 weeks from 3 months of age by intracerebroventricular injection, and responses to seizure induction were characterized. Seizure scores were plotted between scramble ASO sequence and Let-7 ASO ( n = 12,12; two-tailed Mann–Whitney p = 0.0474). G – I Survival curves demonstrating time in seconds between administration of PTZ and onset of G first response ( n = 12, 12; 2-way ANOVA, p = 0.003), H score 3 ( n = 11, 12; p = 0.06), I or score 5 ( n = 6,10). Error bars in ( B , F ) represent SEM.

Article Snippet: The HTR1F agonist LY344864 was ordered from Med Chem Express (Cat. No.: HY-13788).

Techniques: Injection, Control, Two Tailed Test, MANN-WHITNEY, Sequencing