HY-132892 Search Results


nepicastat hydrochloride  (MedChemExpress)
92
MedChemExpress nepicastat hydrochloride
Inhibition of noradrenergic signaling ameliorates CDI disease severity (A) Norepinephrine (NE) concentration in colonic lysates from male CDI mice was measured by ELISA on day 2 post-infection ( n = 6 per group). (B) Male mice were intraperitoneally administered desipramine, a norepinephrine transporter inhibitor, 30 min prior to the administration of 6-OHDA to block the entry of 6-OHDA into noradrenergic terminals. Survival curves after treatment with 6-OHDA (red), 6-OHDA and desipramine (6-OHDA_Des; blue), or vehicle (0.2% ascorbic acid and PBS; black) in C. difficile -infected mice ( n = 10 per group). (C) Weight loss after treatment with 6-OHDA (red), 6-OHDA and desipramine (6-OHDA_Des; blue), or vehicle (0.2% ascorbic acid and PBS; black) in C. difficile -infected mice ( n = 10 per group). (D) <t>Nepicastat</t> inhibits dopamine beta hydroxylase which converts dopamine to norepinephrine. (E) Male mice were orally administered nepicastat (on days 0 and 1 post-infection), an inhibitor of dopamine beta hydroxylase, to inhibit the conversion of dopamine to norepinephrine. Survival curves after treatment with nepicastat (green) or vehicle (ORA-Plus; black) in male C. difficile -infected mice. (F) Weight loss after treatment with nepicastat (green) or vehicle (ORA-Plus; black) in male C. difficile -infected mice. Data represent mean ± SEM. ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001 by Student’s t test (A), Mantel-Cox log rank test (B and E), and mixed effects model for the group factor (C and F). The data for (D) and (E) are pooled from two independent experiments.
Nepicastat Hydrochloride, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/nepicastat hydrochloride/product/MedChemExpress
Average 92 stars, based on 1 article reviews
nepicastat hydrochloride - by Bioz Stars, 2026-03
92/100 stars
  Buy from Supplier

Image Search Results


Inhibition of noradrenergic signaling ameliorates CDI disease severity (A) Norepinephrine (NE) concentration in colonic lysates from male CDI mice was measured by ELISA on day 2 post-infection ( n = 6 per group). (B) Male mice were intraperitoneally administered desipramine, a norepinephrine transporter inhibitor, 30 min prior to the administration of 6-OHDA to block the entry of 6-OHDA into noradrenergic terminals. Survival curves after treatment with 6-OHDA (red), 6-OHDA and desipramine (6-OHDA_Des; blue), or vehicle (0.2% ascorbic acid and PBS; black) in C. difficile -infected mice ( n = 10 per group). (C) Weight loss after treatment with 6-OHDA (red), 6-OHDA and desipramine (6-OHDA_Des; blue), or vehicle (0.2% ascorbic acid and PBS; black) in C. difficile -infected mice ( n = 10 per group). (D) Nepicastat inhibits dopamine beta hydroxylase which converts dopamine to norepinephrine. (E) Male mice were orally administered nepicastat (on days 0 and 1 post-infection), an inhibitor of dopamine beta hydroxylase, to inhibit the conversion of dopamine to norepinephrine. Survival curves after treatment with nepicastat (green) or vehicle (ORA-Plus; black) in male C. difficile -infected mice. (F) Weight loss after treatment with nepicastat (green) or vehicle (ORA-Plus; black) in male C. difficile -infected mice. Data represent mean ± SEM. ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001 by Student’s t test (A), Mantel-Cox log rank test (B and E), and mixed effects model for the group factor (C and F). The data for (D) and (E) are pooled from two independent experiments.

Journal: Cell Reports Medicine

Article Title: The sympathetic nervous system drives hyperinflammatory responses to Clostridioides difficile infection

doi: 10.1016/j.xcrm.2024.101771

Figure Lengend Snippet: Inhibition of noradrenergic signaling ameliorates CDI disease severity (A) Norepinephrine (NE) concentration in colonic lysates from male CDI mice was measured by ELISA on day 2 post-infection ( n = 6 per group). (B) Male mice were intraperitoneally administered desipramine, a norepinephrine transporter inhibitor, 30 min prior to the administration of 6-OHDA to block the entry of 6-OHDA into noradrenergic terminals. Survival curves after treatment with 6-OHDA (red), 6-OHDA and desipramine (6-OHDA_Des; blue), or vehicle (0.2% ascorbic acid and PBS; black) in C. difficile -infected mice ( n = 10 per group). (C) Weight loss after treatment with 6-OHDA (red), 6-OHDA and desipramine (6-OHDA_Des; blue), or vehicle (0.2% ascorbic acid and PBS; black) in C. difficile -infected mice ( n = 10 per group). (D) Nepicastat inhibits dopamine beta hydroxylase which converts dopamine to norepinephrine. (E) Male mice were orally administered nepicastat (on days 0 and 1 post-infection), an inhibitor of dopamine beta hydroxylase, to inhibit the conversion of dopamine to norepinephrine. Survival curves after treatment with nepicastat (green) or vehicle (ORA-Plus; black) in male C. difficile -infected mice. (F) Weight loss after treatment with nepicastat (green) or vehicle (ORA-Plus; black) in male C. difficile -infected mice. Data represent mean ± SEM. ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001 by Student’s t test (A), Mantel-Cox log rank test (B and E), and mixed effects model for the group factor (C and F). The data for (D) and (E) are pooled from two independent experiments.

Article Snippet: Nepicastat hydrochloride , Medchem Express , 13289A.

Techniques: Inhibition, Concentration Assay, Enzyme-linked Immunosorbent Assay, Infection, Blocking Assay

Journal: Cell Reports Medicine

Article Title: The sympathetic nervous system drives hyperinflammatory responses to Clostridioides difficile infection

doi: 10.1016/j.xcrm.2024.101771

Figure Lengend Snippet:

Article Snippet: Nepicastat hydrochloride , Medchem Express , 13289A.

Techniques: Virus, Recombinant, Mutagenesis, Software