HY-131952 Search Results


tlr9 antagonist  (MedChemExpress)
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MedChemExpress tlr9 antagonist
The hypoxic microenvironment induced NET formation through the TLR4/p38 MAPK pathway in neutrophils. A , The mRNA expression of TLR2, TLR4, <t>TLR9</t> and RAGE in neutrophils treated with hypoxic-CM from GC cells was measured by qRT‒PCR. B , Neutrophils isolated from healthy individuals were pretreated with inhibitors of TLR2, TLR4, TLR9 and RAGE for 1 h prior to coculture with hypoxic-CM from GC cells, and the p-p38 level in neutrophils was measured by western blotting. C , NET formation was detected with MPO and citH3 staining. Magnification: 20 × . Scale bars: 50 μm. All values are the means ± SDs. ns = not significant, ** P < 0.01
Tlr9 Antagonist, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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The hypoxic microenvironment induced NET formation through the TLR4/p38 MAPK pathway in neutrophils. A , The mRNA expression of TLR2, TLR4, TLR9 and RAGE in neutrophils treated with hypoxic-CM from GC cells was measured by qRT‒PCR. B , Neutrophils isolated from healthy individuals were pretreated with inhibitors of TLR2, TLR4, TLR9 and RAGE for 1 h prior to coculture with hypoxic-CM from GC cells, and the p-p38 level in neutrophils was measured by western blotting. C , NET formation was detected with MPO and citH3 staining. Magnification: 20 × . Scale bars: 50 μm. All values are the means ± SDs. ns = not significant, ** P < 0.01

Journal: Cell Communication and Signaling : CCS

Article Title: Neutrophil extracellular traps induced by the hypoxic microenvironment in gastric cancer augment tumour growth

doi: 10.1186/s12964-023-01112-5

Figure Lengend Snippet: The hypoxic microenvironment induced NET formation through the TLR4/p38 MAPK pathway in neutrophils. A , The mRNA expression of TLR2, TLR4, TLR9 and RAGE in neutrophils treated with hypoxic-CM from GC cells was measured by qRT‒PCR. B , Neutrophils isolated from healthy individuals were pretreated with inhibitors of TLR2, TLR4, TLR9 and RAGE for 1 h prior to coculture with hypoxic-CM from GC cells, and the p-p38 level in neutrophils was measured by western blotting. C , NET formation was detected with MPO and citH3 staining. Magnification: 20 × . Scale bars: 50 μm. All values are the means ± SDs. ns = not significant, ** P < 0.01

Article Snippet: The inhibitors used in this study included an HMGB1 antagonist (HY-N0184, MCE, USA), a p38 MAPK pathway inhibitor (HY-12839, MCE, USA), a p65 NF-KB pathway inhibitor (HY-138537, MCE, USA), an ERK pathway inhibitor (HY-112287, MCE, USA), a TLR2 antagonist (HY-112146, MCE, USA), a TLR4 antagonist (HY-107575, MCE, USA), a TLR9 antagonist (HY-131952, MCE, USA), and a RAGE antagonist (HY-P2268).

Techniques: Expressing, Isolation, Western Blot, Staining