HY-131183 Search Results


bms-986235  (MedChemExpress)
94
MedChemExpress bms-986235
Bms 986235, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/bms-986235/product/MedChemExpress
Average 94 stars, based on 1 article reviews
bms-986235 - by Bioz Stars, 2026-02
94/100 stars
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lei401  (MedChemExpress)
90
MedChemExpress lei401
(A) Left, Schematic of injection cannula implant in the vLGN. Right, Coronal section with an example injection. Scale bar 1 mm. (B) Left, Schematic of the task design. Right: Boxplot (with median and IQR) of post-learning escape probabilities for different reagents injected before the learning protocol; injection of saline in vLGN (13 mice), mGluR5 antagonist MTEP injection in hippocampus (P = 0.740, 7 mice), MTEP injection in vLGN (P = 0.001, 15 mice), eCB synthesis blockers <t>LEI401</t> and DO34 injection in vLGN (P = 0.0004, 6 mice), and CB1 receptor antagonist Rimonabant injection in vLGN (P=0.0008, 7 mice). KW test followed by Tukey HSD for all conditions. Dots indicate individual animals (C) Left, experimental approach to visualize vLGN neurons receiving input from plHVAs (vLGN plHVA neurons). Right, example of a recorded vLGN plHVA neuron under the microscope. Scale bar 30 µm. (D) Left, Schematic of in-vitro whole-cell recordings from identified vLGN plHVA neurons with bath application of eCB agonist WIN55212-2. Right, boxplots of frequency and amplitude of sIPSCs recorded with and without bath application of the eCB agonist (Freq: P = 0.003; Amp: P = 0.603; paired t-test; n = 12 cells from 4 mice). Dots indicate individual neurons. (E) Top, schematic of whole-cell recordings from identified vLGN plHVA neurons in brain slices from mice before and after learning. Bottom, Membrane potential traces of example neurons in response to current injections of different amplitudes. (F) Example traces of spontaneous inhibitory postsynaptic currents (sIPSCs) under voltage-clamp in vLGN plHVA neurons before (green) or after learning (purple). (G) Boxplots of frequency and amplitude of sIPSCs recorded from mice before and after learning (Freq P = 0.002; Amp P = 0.827 KW test; n = 20 cells from 4 mice before learning, 39 cells from 5 mice after learning). Dots indicate individual neurons. (H) Schematic of the mechanism underlying learnt suppression of escape responses: eCB-mediated inhibitory-LTD of presynaptic inhibition onto vLGN plHVA neurons, likely induced via depolarization induced by direct visual looming stimulus input combined with input from plHVAs. Statistical significance is indicated as **P < 0.001 *** P < 0.001.
Lei401, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/lei401/product/MedChemExpress
Average 90 stars, based on 1 article reviews
lei401 - by Bioz Stars, 2026-02
90/100 stars
  Buy from Supplier
protac pd-1/pd-l1 degrader-1  (MedChemExpress)
N/A
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Image Search Results


(A) Left, Schematic of injection cannula implant in the vLGN. Right, Coronal section with an example injection. Scale bar 1 mm. (B) Left, Schematic of the task design. Right: Boxplot (with median and IQR) of post-learning escape probabilities for different reagents injected before the learning protocol; injection of saline in vLGN (13 mice), mGluR5 antagonist MTEP injection in hippocampus (P = 0.740, 7 mice), MTEP injection in vLGN (P = 0.001, 15 mice), eCB synthesis blockers LEI401 and DO34 injection in vLGN (P = 0.0004, 6 mice), and CB1 receptor antagonist Rimonabant injection in vLGN (P=0.0008, 7 mice). KW test followed by Tukey HSD for all conditions. Dots indicate individual animals (C) Left, experimental approach to visualize vLGN neurons receiving input from plHVAs (vLGN plHVA neurons). Right, example of a recorded vLGN plHVA neuron under the microscope. Scale bar 30 µm. (D) Left, Schematic of in-vitro whole-cell recordings from identified vLGN plHVA neurons with bath application of eCB agonist WIN55212-2. Right, boxplots of frequency and amplitude of sIPSCs recorded with and without bath application of the eCB agonist (Freq: P = 0.003; Amp: P = 0.603; paired t-test; n = 12 cells from 4 mice). Dots indicate individual neurons. (E) Top, schematic of whole-cell recordings from identified vLGN plHVA neurons in brain slices from mice before and after learning. Bottom, Membrane potential traces of example neurons in response to current injections of different amplitudes. (F) Example traces of spontaneous inhibitory postsynaptic currents (sIPSCs) under voltage-clamp in vLGN plHVA neurons before (green) or after learning (purple). (G) Boxplots of frequency and amplitude of sIPSCs recorded from mice before and after learning (Freq P = 0.002; Amp P = 0.827 KW test; n = 20 cells from 4 mice before learning, 39 cells from 5 mice after learning). Dots indicate individual neurons. (H) Schematic of the mechanism underlying learnt suppression of escape responses: eCB-mediated inhibitory-LTD of presynaptic inhibition onto vLGN plHVA neurons, likely induced via depolarization induced by direct visual looming stimulus input combined with input from plHVAs. Statistical significance is indicated as **P < 0.001 *** P < 0.001.

Journal: bioRxiv

Article Title: Overwriting an instinct: visual cortex instructs learning to suppress fear responses

doi: 10.1101/2024.07.31.605567

Figure Lengend Snippet: (A) Left, Schematic of injection cannula implant in the vLGN. Right, Coronal section with an example injection. Scale bar 1 mm. (B) Left, Schematic of the task design. Right: Boxplot (with median and IQR) of post-learning escape probabilities for different reagents injected before the learning protocol; injection of saline in vLGN (13 mice), mGluR5 antagonist MTEP injection in hippocampus (P = 0.740, 7 mice), MTEP injection in vLGN (P = 0.001, 15 mice), eCB synthesis blockers LEI401 and DO34 injection in vLGN (P = 0.0004, 6 mice), and CB1 receptor antagonist Rimonabant injection in vLGN (P=0.0008, 7 mice). KW test followed by Tukey HSD for all conditions. Dots indicate individual animals (C) Left, experimental approach to visualize vLGN neurons receiving input from plHVAs (vLGN plHVA neurons). Right, example of a recorded vLGN plHVA neuron under the microscope. Scale bar 30 µm. (D) Left, Schematic of in-vitro whole-cell recordings from identified vLGN plHVA neurons with bath application of eCB agonist WIN55212-2. Right, boxplots of frequency and amplitude of sIPSCs recorded with and without bath application of the eCB agonist (Freq: P = 0.003; Amp: P = 0.603; paired t-test; n = 12 cells from 4 mice). Dots indicate individual neurons. (E) Top, schematic of whole-cell recordings from identified vLGN plHVA neurons in brain slices from mice before and after learning. Bottom, Membrane potential traces of example neurons in response to current injections of different amplitudes. (F) Example traces of spontaneous inhibitory postsynaptic currents (sIPSCs) under voltage-clamp in vLGN plHVA neurons before (green) or after learning (purple). (G) Boxplots of frequency and amplitude of sIPSCs recorded from mice before and after learning (Freq P = 0.002; Amp P = 0.827 KW test; n = 20 cells from 4 mice before learning, 39 cells from 5 mice after learning). Dots indicate individual neurons. (H) Schematic of the mechanism underlying learnt suppression of escape responses: eCB-mediated inhibitory-LTD of presynaptic inhibition onto vLGN plHVA neurons, likely induced via depolarization induced by direct visual looming stimulus input combined with input from plHVAs. Statistical significance is indicated as **P < 0.001 *** P < 0.001.

Article Snippet: MTEP (CAS 329205-68-7,1 mg); Rimonabant (National Institute on Drug Abuse, Rockville, MD 0.257 mg), and the cocktail of LEI401 (MedChemExpress (Monmouth Junction, NJ 0.5 mg) and DO34 (Aobious (Gloucester, MA) 0.5 mg) were infused into vLGN delivered in a vehicle composed of 1:1:18 of DMSO:Tween80:saline.

Techniques: Injection, Saline, Microscopy, In Vitro, Membrane, Inhibition