Journal: Molecules

Article Title: Evaluation of In Vivo Prepared Albumin-Drug Conjugate Using Immunoprecipitation Linked LC-MS Assay and Its Application to Mouse Pharmacokinetic Study

doi: 10.3390/molecules28073223

Figure Lengend Snippet: Structure of MAC glucuronide phenol linked SN-38 ((2S,3S,4S,5R,6S)-6-(4-(((((((S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano [3′,4′:6,7]indolizino [1,2-b]quinolin-9-yl)oxy)methyl)(2-(methylsulfonyl)ethyl)carbamoyl)oxy)methyl)-2-(2-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-methylpropanamido)acetamido)phenoxy)-3,4,5-trihydroxytetra-hydro-2H-pyran-2-carboxylic acid).

Article Snippet: MAC glucuronide phenol linked SN-38, and SN-38 was purchased from MedChem Express (Monmouth Junction, NJ, USA).

Techniques:

Journal: Molecules

Article Title: Evaluation of In Vivo Prepared Albumin-Drug Conjugate Using Immunoprecipitation Linked LC-MS Assay and Its Application to Mouse Pharmacokinetic Study

doi: 10.3390/molecules28073223

Figure Lengend Snippet: Representative calibration curve of SN-38 released from MAC glucuronide phenol linked SN-38.

Article Snippet: MAC glucuronide phenol linked SN-38, and SN-38 was purchased from MedChem Express (Monmouth Junction, NJ, USA).

Techniques:

Journal: Molecules

Article Title: Evaluation of In Vivo Prepared Albumin-Drug Conjugate Using Immunoprecipitation Linked LC-MS Assay and Its Application to Mouse Pharmacokinetic Study

doi: 10.3390/molecules28073223

Figure Lengend Snippet: Intra/inter-day accuracy and precision of MAC glucuronide phenol linked SN-38 in quality control samples at three levels ( n = 3 for intra-day accuracy and precision; n = 9 for inter-day accuracy and precision).

Article Snippet: MAC glucuronide phenol linked SN-38, and SN-38 was purchased from MedChem Express (Monmouth Junction, NJ, USA).

Techniques: Control, Concentration Assay

Journal: Molecules

Article Title: Evaluation of In Vivo Prepared Albumin-Drug Conjugate Using Immunoprecipitation Linked LC-MS Assay and Its Application to Mouse Pharmacokinetic Study

doi: 10.3390/molecules28073223

Figure Lengend Snippet: The stability assessment of MAC glucuronide phenol linked SN-38 in mouse plasma ( n = 3).

Article Snippet: MAC glucuronide phenol linked SN-38, and SN-38 was purchased from MedChem Express (Monmouth Junction, NJ, USA).

Techniques: Clinical Proteomics, Concentration Assay

Journal: Molecules

Article Title: Evaluation of In Vivo Prepared Albumin-Drug Conjugate Using Immunoprecipitation Linked LC-MS Assay and Its Application to Mouse Pharmacokinetic Study

doi: 10.3390/molecules28073223

Figure Lengend Snippet: Plasma stability test result of albumin conjugated MAC glucuronide phenol linked SN-38 in mouse and human plasma.

Article Snippet: MAC glucuronide phenol linked SN-38, and SN-38 was purchased from MedChem Express (Monmouth Junction, NJ, USA).

Techniques: Clinical Proteomics

Journal: Molecules

Article Title: Evaluation of In Vivo Prepared Albumin-Drug Conjugate Using Immunoprecipitation Linked LC-MS Assay and Its Application to Mouse Pharmacokinetic Study

doi: 10.3390/molecules28073223

Figure Lengend Snippet: Pharmacokinetic profiles of SN-38 at 1 mg/kg and albumin conjugated SN-38 at 1 mg/kg and 3 mg/kg MAC glucuronide phenol linked SN-38 after Intravenous administration.

Article Snippet: MAC glucuronide phenol linked SN-38, and SN-38 was purchased from MedChem Express (Monmouth Junction, NJ, USA).

Techniques:

Journal: Molecules

Article Title: Evaluation of In Vivo Prepared Albumin-Drug Conjugate Using Immunoprecipitation Linked LC-MS Assay and Its Application to Mouse Pharmacokinetic Study

doi: 10.3390/molecules28073223

Figure Lengend Snippet: Pharmacokinetic parameters of SN-38 at 1 mg/kg and albumin conjugated SN-38 at 1 mg/kg and 3 mg/kg of MAC glucuronide phenol linked SN-38 (as an equivalent dose of SN-38, 0.36 and 1.08 mg/kg respectively) after intravenous administration.

Article Snippet: MAC glucuronide phenol linked SN-38, and SN-38 was purchased from MedChem Express (Monmouth Junction, NJ, USA).

Techniques:

Journal: Molecules

Article Title: Evaluation of In Vivo Prepared Albumin-Drug Conjugate Using Immunoprecipitation Linked LC-MS Assay and Its Application to Mouse Pharmacokinetic Study

doi: 10.3390/molecules28073223

Figure Lengend Snippet: Dose proportionality evaluation between 1 and 3 mg/kg of MAC glucuronide phenol linked SN-38 using the power regression model.

Article Snippet: MAC glucuronide phenol linked SN-38, and SN-38 was purchased from MedChem Express (Monmouth Junction, NJ, USA).

Techniques:

Journal: Molecules

Article Title: Evaluation of In Vivo Prepared Albumin-Drug Conjugate Using Immunoprecipitation Linked LC-MS Assay and Its Application to Mouse Pharmacokinetic Study

doi: 10.3390/molecules28073223

Figure Lengend Snippet: Mechanism of SN-38 release from MAC glucuronide phenol linked SN-38 after incubation with β-glucuronidase.

Article Snippet: MAC glucuronide phenol linked SN-38, and SN-38 was purchased from MedChem Express (Monmouth Junction, NJ, USA).

Techniques: Incubation