Journal: Heliyon

Article Title: Development and validation of stability-indicating method of etrasimod by HPLC/DAD/MS/MS technique with greenness profiling

doi: 10.1016/j.heliyon.2024.e34066

Figure Lengend Snippet: Chemical structure of sphingosine-1-phosphate (S1P) receptor modulator etrasimod.

Article Snippet: Etrasimod standard was purchased from MedChemExpress (Monmouth Junction, NJ, USA) with purity of 99.82 % (according to supplier certificate analysis).

Techniques:

Journal: Heliyon

Article Title: Development and validation of stability-indicating method of etrasimod by HPLC/DAD/MS/MS technique with greenness profiling

doi: 10.1016/j.heliyon.2024.e34066

Figure Lengend Snippet: Stability-indicating method validation data for determination of etrasimod.

Article Snippet: Etrasimod standard was purchased from MedChemExpress (Monmouth Junction, NJ, USA) with purity of 99.82 % (according to supplier certificate analysis).

Techniques: Quantitation Assay

Journal: Heliyon

Article Title: Development and validation of stability-indicating method of etrasimod by HPLC/DAD/MS/MS technique with greenness profiling

doi: 10.1016/j.heliyon.2024.e34066

Figure Lengend Snippet: Representative chromatograms of etrasimod under acidic (A), oxidative (B), and photolytic (C) stress conditions.

Article Snippet: Etrasimod standard was purchased from MedChemExpress (Monmouth Junction, NJ, USA) with purity of 99.82 % (according to supplier certificate analysis).

Techniques:

Journal: Heliyon

Article Title: Development and validation of stability-indicating method of etrasimod by HPLC/DAD/MS/MS technique with greenness profiling

doi: 10.1016/j.heliyon.2024.e34066

Figure Lengend Snippet: Forced degradation study results.

Article Snippet: Etrasimod standard was purchased from MedChemExpress (Monmouth Junction, NJ, USA) with purity of 99.82 % (according to supplier certificate analysis).

Techniques:

Journal: Heliyon

Article Title: Development and validation of stability-indicating method of etrasimod by HPLC/DAD/MS/MS technique with greenness profiling

doi: 10.1016/j.heliyon.2024.e34066

Figure Lengend Snippet: Retention and mass spectrometric data of etrasimod and degradation products obtained by forced degradation study.

Article Snippet: Etrasimod standard was purchased from MedChemExpress (Monmouth Junction, NJ, USA) with purity of 99.82 % (according to supplier certificate analysis).

Techniques:

Journal: Heliyon

Article Title: Development and validation of stability-indicating method of etrasimod by HPLC/DAD/MS/MS technique with greenness profiling

doi: 10.1016/j.heliyon.2024.e34066

Figure Lengend Snippet: MS and MS/MS spectra of etrasimod: positive ESI-MS spectrum ( A ), negative ESI-MS spectrum ( B ), and ESI-MS/MS spectrum of [M+H] + ion ( m/z 458) with proposed fragmentation pattern ( C ).

Article Snippet: Etrasimod standard was purchased from MedChemExpress (Monmouth Junction, NJ, USA) with purity of 99.82 % (according to supplier certificate analysis).

Techniques: Tandem Mass Spectroscopy

Journal: Heliyon

Article Title: Development and validation of stability-indicating method of etrasimod by HPLC/DAD/MS/MS technique with greenness profiling

doi: 10.1016/j.heliyon.2024.e34066

Figure Lengend Snippet: The ComplexGAPI pictogram of etrasimod forced degradation study. Legend: 1 – collection, 2 – preservation, 3 – transport, 4 – storage, 5 – type of method, 6 – scale of extraction, 7 – solvents/reagents used, 8 – additional treatment, 9 – amount of reagents and solvents, 10 – health hazard of reagents and solvents, 11 – safety hazard of reagents and solvents, 12 – instrumentation energy, 13 – occupational hazard, 14 – waste, 15 – waste treatment, I – yield, II – pre-analysis temperature and time, III – relation to green economy, IV a – health hazard of reagents and solvents used in pre-analysis, IV b – safety hazard of reagents and solvents used in pre-analysis, V a – technical set up, V b – energy of instruments used in pre-analysis, V c – occupational hazard of pre-analysis, VI a – end products workup, VI b – purity. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Article Snippet: Etrasimod standard was purchased from MedChemExpress (Monmouth Junction, NJ, USA) with purity of 99.82 % (according to supplier certificate analysis).

Techniques: Preserving, Extraction

Journal: Heliyon

Article Title: Development and validation of stability-indicating method of etrasimod by HPLC/DAD/MS/MS technique with greenness profiling

doi: 10.1016/j.heliyon.2024.e34066

Figure Lengend Snippet: The AGREE pictogram of etrasimod forced degradation study. Legend: 1 – sample procedure, 2 – sample size, 3 – sampling, 4 – sample preparation steps, 5 – automatization, 6 – derivatization, 7 – waste, 8 – analysis throughput, 9 – energy consumption, 10 – renewable reagents, 11 – toxicity of reagents, 12 – operator’ safety.

Article Snippet: Etrasimod standard was purchased from MedChemExpress (Monmouth Junction, NJ, USA) with purity of 99.82 % (according to supplier certificate analysis).

Techniques: Sampling, Sample Prep

Journal: Heliyon

Article Title: Development and validation of stability-indicating method of etrasimod by HPLC/DAD/MS/MS technique with greenness profiling

doi: 10.1016/j.heliyon.2024.e34066

Figure Lengend Snippet: The AGREEprep pictogram of etrasimod forced degradation study. Legend: AGREEprep: 1 – sampling, 2 – hazardous materials, 3 – sustainability, renewability, and reusability of materials, 4 – waste, 5 – economy of a sample, 6 – sample throughput, 7 – automatization, 8 – energy consumption, 9 – analytical instrumentation, 10 – operator's safety.

Article Snippet: Etrasimod standard was purchased from MedChemExpress (Monmouth Junction, NJ, USA) with purity of 99.82 % (according to supplier certificate analysis).

Techniques: Sampling