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antagonist nibr189  (MedChemExpress)
90
MedChemExpress antagonist nibr189
Fig. 3. Role of chemicals targeting GPR183 in the early infection and the replication of Mtb in macrophages. (A) The cell viability under the treatment of <t>NIBR189</t> and 7α,25-OHC at different time points changes little, determined by MTS assay (n = 5). (B) Bacterial early infection (4 h poi) is compromised under the treatment of NIBR189 and 7α,25-OHC in RAW264.7. (CFU in left panel, TTD in right panel) (C) The effect of NIBR189 and 7α,25-OHC on intracellular Mtb replication is compared using cfu at different time points after infection in RAW264.7 (n = 5). (D) NIBR189 and 7α,25-OHC exert little modulation on Gpr183 mRNA expression. n.s. p > 0.05. n = 5. (E) BMDMs from C57BL/6 and Ifnar1−/−mice were infected with Mtb for 24 and 48 h, under the treatment of 25 nM NIBR189 or 100 nM 7α,25-OHC. The time-to-detection scored by MGIT960 system is compared between groups. *p < 0.05, **p < 0.01, ***p < 0.001. Each experiment was repeated at least three times and the representative experiment is shown. Error bars represent standard deviation (SD).
Antagonist Nibr189, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Fig. 3. Role of chemicals targeting GPR183 in the early infection and the replication of Mtb in macrophages. (A) The cell viability under the treatment of NIBR189 and 7α,25-OHC at different time points changes little, determined by MTS assay (n = 5). (B) Bacterial early infection (4 h poi) is compromised under the treatment of NIBR189 and 7α,25-OHC in RAW264.7. (CFU in left panel, TTD in right panel) (C) The effect of NIBR189 and 7α,25-OHC on intracellular Mtb replication is compared using cfu at different time points after infection in RAW264.7 (n = 5). (D) NIBR189 and 7α,25-OHC exert little modulation on Gpr183 mRNA expression. n.s. p > 0.05. n = 5. (E) BMDMs from C57BL/6 and Ifnar1−/−mice were infected with Mtb for 24 and 48 h, under the treatment of 25 nM NIBR189 or 100 nM 7α,25-OHC. The time-to-detection scored by MGIT960 system is compared between groups. *p < 0.05, **p < 0.01, ***p < 0.001. Each experiment was repeated at least three times and the representative experiment is shown. Error bars represent standard deviation (SD).

Journal: Microbial pathogenesis

Article Title: Downregulation of GPR183 on infection restricts the early infection and intracellular replication of mycobacterium tuberculosis in macrophage.

doi: 10.1016/j.micpath.2020.104234

Figure Lengend Snippet: Fig. 3. Role of chemicals targeting GPR183 in the early infection and the replication of Mtb in macrophages. (A) The cell viability under the treatment of NIBR189 and 7α,25-OHC at different time points changes little, determined by MTS assay (n = 5). (B) Bacterial early infection (4 h poi) is compromised under the treatment of NIBR189 and 7α,25-OHC in RAW264.7. (CFU in left panel, TTD in right panel) (C) The effect of NIBR189 and 7α,25-OHC on intracellular Mtb replication is compared using cfu at different time points after infection in RAW264.7 (n = 5). (D) NIBR189 and 7α,25-OHC exert little modulation on Gpr183 mRNA expression. n.s. p > 0.05. n = 5. (E) BMDMs from C57BL/6 and Ifnar1−/−mice were infected with Mtb for 24 and 48 h, under the treatment of 25 nM NIBR189 or 100 nM 7α,25-OHC. The time-to-detection scored by MGIT960 system is compared between groups. *p < 0.05, **p < 0.01, ***p < 0.001. Each experiment was repeated at least three times and the representative experiment is shown. Error bars represent standard deviation (SD).

Article Snippet: 7α,25-OHC is from Sigma-Aldrich and antagonist NIBR189 is from MCE.

Techniques: Infection, MTS Assay, Expressing, Standard Deviation