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ono 8711  (MedChemExpress)
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MedChemExpress ono 8711
Effects of prostanoid receptor antagonists, a tachykinin NK 1 receptor antagonist, a bradykinin B 2 receptor antagonist and a cyclooxygenase inhibitor on treprostinil (TRE) cough in guinea pigs. The compound (blue bars) or their respective vehicles (white bars) were administered intraperitoneally (30 min) or by aerosol (10 min) prior to nebulised TRE (3.30 μg·kg −1 ). Graphs show the mean± sem effects against TRE-induced cough of a) the IP receptor antagonist (RO 1138452, 10 mg·kg −1 i.p ., n=5), the EP 1 receptor antagonist <t>(ONO-8711,</t> 10 mg·kg −1 i.p ., n=5–6), the EP 2 receptor antagonist (PF-04418948, 5 mg·kg −1 i.p ., n=5), the EP 3 receptor antagonist (L-798106, 10 mg·kg −1 i.p ., n=5–7) and the DP 1 receptor antagonist (BW A868C 10 mg·kg −1 i.p ., n=5); and b) the NK 1 receptor antagonist (CP99994, 10 mg·kg −1 , i.p ., n=5), the bradykinin B 2 receptor antagonist (HOE 140, 1 mg·mL −1 delivered by aerosol, n=3) and the cyclooxygenase (COX) inhibitor (meclofenamic acid, 1 mg·kg −1 i.p ., n=3). *: p<0.05 compared to vehicle.
Ono 8711, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Effects of prostanoid receptor antagonists, a tachykinin NK 1 receptor antagonist, a bradykinin B 2 receptor antagonist and a cyclooxygenase inhibitor on treprostinil (TRE) cough in guinea pigs. The compound (blue bars) or their respective vehicles (white bars) were administered intraperitoneally (30 min) or by aerosol (10 min) prior to nebulised TRE (3.30 μg·kg −1 ). Graphs show the mean± sem effects against TRE-induced cough of a) the IP receptor antagonist (RO 1138452, 10 mg·kg −1 i.p ., n=5), the EP 1 receptor antagonist (ONO-8711, 10 mg·kg −1 i.p ., n=5–6), the EP 2 receptor antagonist (PF-04418948, 5 mg·kg −1 i.p ., n=5), the EP 3 receptor antagonist (L-798106, 10 mg·kg −1 i.p ., n=5–7) and the DP 1 receptor antagonist (BW A868C 10 mg·kg −1 i.p ., n=5); and b) the NK 1 receptor antagonist (CP99994, 10 mg·kg −1 , i.p ., n=5), the bradykinin B 2 receptor antagonist (HOE 140, 1 mg·mL −1 delivered by aerosol, n=3) and the cyclooxygenase (COX) inhibitor (meclofenamic acid, 1 mg·kg −1 i.p ., n=3). *: p<0.05 compared to vehicle.

Journal: ERJ Open Research

Article Title: Characterisation of cough evoked by inhaled treprostinil and treprostinil palmitil

doi: 10.1183/23120541.00592-2020

Figure Lengend Snippet: Effects of prostanoid receptor antagonists, a tachykinin NK 1 receptor antagonist, a bradykinin B 2 receptor antagonist and a cyclooxygenase inhibitor on treprostinil (TRE) cough in guinea pigs. The compound (blue bars) or their respective vehicles (white bars) were administered intraperitoneally (30 min) or by aerosol (10 min) prior to nebulised TRE (3.30 μg·kg −1 ). Graphs show the mean± sem effects against TRE-induced cough of a) the IP receptor antagonist (RO 1138452, 10 mg·kg −1 i.p ., n=5), the EP 1 receptor antagonist (ONO-8711, 10 mg·kg −1 i.p ., n=5–6), the EP 2 receptor antagonist (PF-04418948, 5 mg·kg −1 i.p ., n=5), the EP 3 receptor antagonist (L-798106, 10 mg·kg −1 i.p ., n=5–7) and the DP 1 receptor antagonist (BW A868C 10 mg·kg −1 i.p ., n=5); and b) the NK 1 receptor antagonist (CP99994, 10 mg·kg −1 , i.p ., n=5), the bradykinin B 2 receptor antagonist (HOE 140, 1 mg·mL −1 delivered by aerosol, n=3) and the cyclooxygenase (COX) inhibitor (meclofenamic acid, 1 mg·kg −1 i.p ., n=3). *: p<0.05 compared to vehicle.

Article Snippet: The following prostanoid, tachykinin and bradykinin antagonists were purchased: RO 1138452 (IP), ONO-8711 (EP 1 ), PF-04418948 (EP 2 ), L-798,106 (EP 3 ), BW A868C (DP 1 ) (Cayman Chemical, Ann Arbor, MI, USA), CP99994 (NK 1 ) (Tocris Bioscience, Bristol, UK) and HOE 140 (bradykinin B 2 ) (MedChem Express, Monmouth Junction, NJ, USA).

Techniques: Aerosol