Journal: Molecules

Article Title: Development of Novel Pyridine-Thiazole Hybrid Molecules as Potential Anticancer Agents

doi: 10.3390/molecules27196219

Figure Lengend Snippet: Preincubation of MCF-7 cells with PARP1 inhibitor Fluzoparib decreased their sensitivity to the treatment with compounds 4 ( A ) and 3 ( B ). MTT data on 72 h of cells incubation with studied compounds 3 and 4 (** p < 0.01, *** p < 0.001, **** p < 0.0001).

Article Snippet: To determine PARP inactivation, the MCF-7 cells were pretreated for 2 h in the non-toxic concentrations of 5, 10, 15 µM of the Fluzoparib (Med Chem Express, Monmouth Junction, NJ, USA), a potent PARP1 inhibitor used in the chemotherapy [ ].

Techniques: Incubation

Journal: Molecules

Article Title: Development of Novel Pyridine-Thiazole Hybrid Molecules as Potential Anticancer Agents

doi: 10.3390/molecules27196219

Figure Lengend Snippet: Docking scores of the studied compounds.

Article Snippet: To determine PARP inactivation, the MCF-7 cells were pretreated for 2 h in the non-toxic concentrations of 5, 10, 15 µM of the Fluzoparib (Med Chem Express, Monmouth Junction, NJ, USA), a potent PARP1 inhibitor used in the chemotherapy [ ].

Techniques: Binding Assay, Inhibition