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fin group  (MedChemExpress)
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MedChemExpress fin group
Effect <t>of</t> <t>finerenone</t> on dysfunctional mitochondria, mitoROS generation, and HK-2 cell apoptosis. (A) MitoTracker (red) staining evaluated the mitochondrial morphology. Scale bar: 5 μm. (B) Mitochondrial and intracellular ROS production was assessed by H 2 -DCFDA (green) or MitoSOX (red) staining. Scale bar: 20 μm. (C–D) The degree of mitochondrial fragmentation was quantified, and mitochondrial oxidative stress in the NG, HG, and <t>FIN</t> groups was evaluated by ImageJ (n = 6). (E–F) Quantitative analysis and representative immunoblots of the apoptosis-related proteins, Bax and Cyt C (n = 3). (G–H) TUNEL staining was used to determine the apoptosis. Scale bar: 50 μm. Quantitative analysis of the TUNEL-positive tubular cells in the above groups as evaluated by ImageJ (n = 3). Data are indicated as means ± SEM; * P <0.05 vs. the CON group, # P < 0.05 vs . the HG group.
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Effect of finerenone on dysfunctional mitochondria, mitoROS generation, and HK-2 cell apoptosis. (A) MitoTracker (red) staining evaluated the mitochondrial morphology. Scale bar: 5 μm. (B) Mitochondrial and intracellular ROS production was assessed by H 2 -DCFDA (green) or MitoSOX (red) staining. Scale bar: 20 μm. (C–D) The degree of mitochondrial fragmentation was quantified, and mitochondrial oxidative stress in the NG, HG, and FIN groups was evaluated by ImageJ (n = 6). (E–F) Quantitative analysis and representative immunoblots of the apoptosis-related proteins, Bax and Cyt C (n = 3). (G–H) TUNEL staining was used to determine the apoptosis. Scale bar: 50 μm. Quantitative analysis of the TUNEL-positive tubular cells in the above groups as evaluated by ImageJ (n = 3). Data are indicated as means ± SEM; * P <0.05 vs. the CON group, # P < 0.05 vs . the HG group.

Journal: Redox Biology

Article Title: Non-steroidal mineralocorticoid receptor antagonist finerenone ameliorates mitochondrial dysfunction via PI3K/Akt/eNOS signaling pathway in diabetic tubulopathy

doi: 10.1016/j.redox.2023.102946

Figure Lengend Snippet: Effect of finerenone on dysfunctional mitochondria, mitoROS generation, and HK-2 cell apoptosis. (A) MitoTracker (red) staining evaluated the mitochondrial morphology. Scale bar: 5 μm. (B) Mitochondrial and intracellular ROS production was assessed by H 2 -DCFDA (green) or MitoSOX (red) staining. Scale bar: 20 μm. (C–D) The degree of mitochondrial fragmentation was quantified, and mitochondrial oxidative stress in the NG, HG, and FIN groups was evaluated by ImageJ (n = 6). (E–F) Quantitative analysis and representative immunoblots of the apoptosis-related proteins, Bax and Cyt C (n = 3). (G–H) TUNEL staining was used to determine the apoptosis. Scale bar: 50 μm. Quantitative analysis of the TUNEL-positive tubular cells in the above groups as evaluated by ImageJ (n = 3). Data are indicated as means ± SEM; * P <0.05 vs. the CON group, # P < 0.05 vs . the HG group.

Article Snippet: The mice in the FIN group were given finerenone (MedChemExpress, USA) orally at 3 mg/kg/d for 12 weeks.

Techniques: Staining, Western Blot, TUNEL Assay

Finerenone attenuates HG-induced mitochondrial dynamics and abnormal mitophagy in HK-2 cells. (A–B) Quantitative analysis of mitochondrial dynamic regulatory proteins and representative immunoblots containing Drp1, Fis, Mfn1, Mfn2, and OPA from the NG, HG, and FIN groups (n = 3). (C) Confocal images of Drp1 (green), Mfn2 (red), and LC3-II (yellow) in HK-2 cells. The nuclei were counterstained with DAPI (blue). (D–F) Quantification of the degree of Drp1, Mfn2, and LC3-II by ImageJ (n-3). (G–H) Representative immunoblots and quantitative analysis of the mitophagy regulating proteins, such as LC3-II, p62, Atg5, Atg7, and Beclin-1 from the above three groups (n = 3). Data are shown as means ± SEM; * P <0.05 vs. the NG group, # P < 0.05 vs . the HG group.

Journal: Redox Biology

Article Title: Non-steroidal mineralocorticoid receptor antagonist finerenone ameliorates mitochondrial dysfunction via PI3K/Akt/eNOS signaling pathway in diabetic tubulopathy

doi: 10.1016/j.redox.2023.102946

Figure Lengend Snippet: Finerenone attenuates HG-induced mitochondrial dynamics and abnormal mitophagy in HK-2 cells. (A–B) Quantitative analysis of mitochondrial dynamic regulatory proteins and representative immunoblots containing Drp1, Fis, Mfn1, Mfn2, and OPA from the NG, HG, and FIN groups (n = 3). (C) Confocal images of Drp1 (green), Mfn2 (red), and LC3-II (yellow) in HK-2 cells. The nuclei were counterstained with DAPI (blue). (D–F) Quantification of the degree of Drp1, Mfn2, and LC3-II by ImageJ (n-3). (G–H) Representative immunoblots and quantitative analysis of the mitophagy regulating proteins, such as LC3-II, p62, Atg5, Atg7, and Beclin-1 from the above three groups (n = 3). Data are shown as means ± SEM; * P <0.05 vs. the NG group, # P < 0.05 vs . the HG group.

Article Snippet: The mice in the FIN group were given finerenone (MedChemExpress, USA) orally at 3 mg/kg/d for 12 weeks.

Techniques: Western Blot