HY-110143 Search Results


clp257  (MedChemExpress)
90
MedChemExpress clp257
Muscimol or <t>CLP257</t> dose-dependently inhibits RIH. (A, B) PWMT were evaluated at −24 h (baseline) and 4 h, 8 h, 16 h and 24 h after remifentanil administration. Data were expressed as percent change from the baseline (mean ± SD) ( n = 6). (C, E) Bands of western blot for the expression of GABAAα2R or KCC2 at 24 h after remifentanil administration. (D, F) The fold change for the density of GABAAα2R or KCC2 normalized to the GAPDH level. Data were expressed as mean ± SD ( n = 4). ** p < 0.01 group C; # p < 0.05 or ## p < 0.01 versus group RI; $ p < 0.05 or $$ p < 0.01 versus group low; & p < 0.05 or && p < 0.01 versus group medium.
Clp257, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Muscimol or CLP257 dose-dependently inhibits RIH. (A, B) PWMT were evaluated at −24 h (baseline) and 4 h, 8 h, 16 h and 24 h after remifentanil administration. Data were expressed as percent change from the baseline (mean ± SD) ( n = 6). (C, E) Bands of western blot for the expression of GABAAα2R or KCC2 at 24 h after remifentanil administration. (D, F) The fold change for the density of GABAAα2R or KCC2 normalized to the GAPDH level. Data were expressed as mean ± SD ( n = 4). ** p < 0.01 group C; # p < 0.05 or ## p < 0.01 versus group RI; $ p < 0.05 or $$ p < 0.01 versus group low; & p < 0.05 or && p < 0.01 versus group medium.

Journal: Molecular Pain

Article Title: KCC2 receptor upregulation potentiates antinociceptive effect of GABAAR agonist on remifentanil-induced hyperalgesia

doi: 10.1177/17448069221082880

Figure Lengend Snippet: Muscimol or CLP257 dose-dependently inhibits RIH. (A, B) PWMT were evaluated at −24 h (baseline) and 4 h, 8 h, 16 h and 24 h after remifentanil administration. Data were expressed as percent change from the baseline (mean ± SD) ( n = 6). (C, E) Bands of western blot for the expression of GABAAα2R or KCC2 at 24 h after remifentanil administration. (D, F) The fold change for the density of GABAAα2R or KCC2 normalized to the GAPDH level. Data were expressed as mean ± SD ( n = 4). ** p < 0.01 group C; # p < 0.05 or ## p < 0.01 versus group RI; $ p < 0.05 or $$ p < 0.01 versus group low; & p < 0.05 or && p < 0.01 versus group medium.

Article Snippet: Both muscimol (M1523, Sigma-Aldrich, St Louis, MO, USA, dissolved in 0.05 M HCl) and CLP257 (HY-110,143, MedChemExpress, Monmouth Junction, NJ, USA, dissolved in 1% DMSO) were intrathecally injected through intrathecal catheter.

Techniques: Western Blot, Expressing

The additive effects of CLP257 with muscimol in the reversion of pathogenesis of RIH. (A) PWMT was evaluated at −24 h (baseline) and 4 h, 8 h, 16 h and 24 h after remifentanil administration. Data were expressed as percent change from the baseline (mean ± SD) ( n = 6). (B) Bands of western blot for the expression of KCC2, pKCC2, GABAAα2R and c-fos at 24 h. (C) The fold change for the density of KCC2, GABAAα2R or c-fos normalized to the GAPDH level. Data were expressed as mean ± SD ( n = 4). * p < 0.05 or ** p < 0.01 versus group C; # p < 0.05 or ## p < 0.01 versus group RI; $ p < 0.05 or $$ p < 0.01 versus group Mus; & p < 0.05 or && p < 0.01 versus group CLP.

Journal: Molecular Pain

Article Title: KCC2 receptor upregulation potentiates antinociceptive effect of GABAAR agonist on remifentanil-induced hyperalgesia

doi: 10.1177/17448069221082880

Figure Lengend Snippet: The additive effects of CLP257 with muscimol in the reversion of pathogenesis of RIH. (A) PWMT was evaluated at −24 h (baseline) and 4 h, 8 h, 16 h and 24 h after remifentanil administration. Data were expressed as percent change from the baseline (mean ± SD) ( n = 6). (B) Bands of western blot for the expression of KCC2, pKCC2, GABAAα2R and c-fos at 24 h. (C) The fold change for the density of KCC2, GABAAα2R or c-fos normalized to the GAPDH level. Data were expressed as mean ± SD ( n = 4). * p < 0.05 or ** p < 0.01 versus group C; # p < 0.05 or ## p < 0.01 versus group RI; $ p < 0.05 or $$ p < 0.01 versus group Mus; & p < 0.05 or && p < 0.01 versus group CLP.

Article Snippet: Both muscimol (M1523, Sigma-Aldrich, St Louis, MO, USA, dissolved in 0.05 M HCl) and CLP257 (HY-110,143, MedChemExpress, Monmouth Junction, NJ, USA, dissolved in 1% DMSO) were intrathecally injected through intrathecal catheter.

Techniques: Western Blot, Expressing