HY-109054 Search Results


e2609  (MedChemExpress)
90
MedChemExpress e2609
(A) Cellular BACE1 levels were measured by immunoblot after treatment of HEK293-sw cells with 25 μg/ml cycloheximide together with either DMSO or 2.5 μM AZD3293 for 0.5, 1, 2, 4 and 6 h. α-Tubulin serves as loading control. (B-C) Cellular BACE1 levels were measured by ELISA after treatment of HEK293-sw cells with 25 μg/ml cycloheximide together with either DMSO or 0.1 μM L685,458 (negative control) or else 0.1 μM of six different BACE1 inhibitors (LY2811376, AZD3839, AZD3293, PF −06751979, Inhibitor IV, <t>E2609)</t> for 0.5, 1, 2, 4 and 6 h. (n=3; means +/− SD) (D) BACE1 ELISA of FPLC fractions from HEK293-sw cells treated with AZD3293 for 24 h or else AZD3293 for 24 h followed by another 24 h wash out with medium only (n=2; means +/− SD). (E) Cellular BACE1 level were measured by immunoblot after treatment of rat primary cortical neurons (DIV15) with 25 μg/ml cycloheximide plus DMSO or 2.5 μM AZD3293 for 0.5, 1, 2, 4 and 6 h. SNAP25 serves as loading control.
E2609, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/e2609/product/MedChemExpress
Average 90 stars, based on 1 article reviews
e2609 - by Bioz Stars, 2026-02
90/100 stars
  Buy from Supplier
chymase inhibitor hy 109059  (MedChemExpress)
91
MedChemExpress chymase inhibitor hy 109059
(A) Cellular BACE1 levels were measured by immunoblot after treatment of HEK293-sw cells with 25 μg/ml cycloheximide together with either DMSO or 2.5 μM AZD3293 for 0.5, 1, 2, 4 and 6 h. α-Tubulin serves as loading control. (B-C) Cellular BACE1 levels were measured by ELISA after treatment of HEK293-sw cells with 25 μg/ml cycloheximide together with either DMSO or 0.1 μM L685,458 (negative control) or else 0.1 μM of six different BACE1 inhibitors (LY2811376, AZD3839, AZD3293, PF −06751979, Inhibitor IV, <t>E2609)</t> for 0.5, 1, 2, 4 and 6 h. (n=3; means +/− SD) (D) BACE1 ELISA of FPLC fractions from HEK293-sw cells treated with AZD3293 for 24 h or else AZD3293 for 24 h followed by another 24 h wash out with medium only (n=2; means +/− SD). (E) Cellular BACE1 level were measured by immunoblot after treatment of rat primary cortical neurons (DIV15) with 25 μg/ml cycloheximide plus DMSO or 2.5 μM AZD3293 for 0.5, 1, 2, 4 and 6 h. SNAP25 serves as loading control.
Chymase Inhibitor Hy 109059, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/chymase inhibitor hy 109059/product/MedChemExpress
Average 91 stars, based on 1 article reviews
chymase inhibitor hy 109059 - by Bioz Stars, 2026-02
91/100 stars
  Buy from Supplier
firibastat  (MedChemExpress)
90
MedChemExpress firibastat
(A) Cellular BACE1 levels were measured by immunoblot after treatment of HEK293-sw cells with 25 μg/ml cycloheximide together with either DMSO or 2.5 μM AZD3293 for 0.5, 1, 2, 4 and 6 h. α-Tubulin serves as loading control. (B-C) Cellular BACE1 levels were measured by ELISA after treatment of HEK293-sw cells with 25 μg/ml cycloheximide together with either DMSO or 0.1 μM L685,458 (negative control) or else 0.1 μM of six different BACE1 inhibitors (LY2811376, AZD3839, AZD3293, PF −06751979, Inhibitor IV, <t>E2609)</t> for 0.5, 1, 2, 4 and 6 h. (n=3; means +/− SD) (D) BACE1 ELISA of FPLC fractions from HEK293-sw cells treated with AZD3293 for 24 h or else AZD3293 for 24 h followed by another 24 h wash out with medium only (n=2; means +/− SD). (E) Cellular BACE1 level were measured by immunoblot after treatment of rat primary cortical neurons (DIV15) with 25 μg/ml cycloheximide plus DMSO or 2.5 μM AZD3293 for 0.5, 1, 2, 4 and 6 h. SNAP25 serves as loading control.
Firibastat, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/firibastat/product/MedChemExpress
Average 90 stars, based on 1 article reviews
firibastat - by Bioz Stars, 2026-02
90/100 stars
  Buy from Supplier
enarodustat  (MedChemExpress)
93
MedChemExpress enarodustat
Elemental Composition, Molecular Ions, Retention Times (RTs), LODs, REs, ME, and Suppliers of the Compounds Included in sections S0, S1, S2, and S3 of the WADA List and of the Confounding Factors
Enarodustat, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/enarodustat/product/MedChemExpress
Average 93 stars, based on 1 article reviews
enarodustat - by Bioz Stars, 2026-02
93/100 stars
  Buy from Supplier
delgocitinib  (MedChemExpress)
94
MedChemExpress delgocitinib
Elemental Composition, Molecular Ions, Retention Times (RTs), LODs, REs, ME, and Suppliers of the Compounds Included in sections S0, S1, S2, and S3 of the WADA List and of the Confounding Factors
Delgocitinib, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/delgocitinib/product/MedChemExpress
Average 94 stars, based on 1 article reviews
delgocitinib - by Bioz Stars, 2026-02
94/100 stars
  Buy from Supplier
alobresib  (MedChemExpress)
90
MedChemExpress alobresib
Elemental Composition, Molecular Ions, Retention Times (RTs), LODs, REs, ME, and Suppliers of the Compounds Included in sections S0, S1, S2, and S3 of the WADA List and of the Confounding Factors
Alobresib, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/alobresib/product/MedChemExpress
Average 90 stars, based on 1 article reviews
alobresib - by Bioz Stars, 2026-02
90/100 stars
  Buy from Supplier

Image Search Results


(A) Cellular BACE1 levels were measured by immunoblot after treatment of HEK293-sw cells with 25 μg/ml cycloheximide together with either DMSO or 2.5 μM AZD3293 for 0.5, 1, 2, 4 and 6 h. α-Tubulin serves as loading control. (B-C) Cellular BACE1 levels were measured by ELISA after treatment of HEK293-sw cells with 25 μg/ml cycloheximide together with either DMSO or 0.1 μM L685,458 (negative control) or else 0.1 μM of six different BACE1 inhibitors (LY2811376, AZD3839, AZD3293, PF −06751979, Inhibitor IV, E2609) for 0.5, 1, 2, 4 and 6 h. (n=3; means +/− SD) (D) BACE1 ELISA of FPLC fractions from HEK293-sw cells treated with AZD3293 for 24 h or else AZD3293 for 24 h followed by another 24 h wash out with medium only (n=2; means +/− SD). (E) Cellular BACE1 level were measured by immunoblot after treatment of rat primary cortical neurons (DIV15) with 25 μg/ml cycloheximide plus DMSO or 2.5 μM AZD3293 for 0.5, 1, 2, 4 and 6 h. SNAP25 serves as loading control.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association

Article Title: Multiple BACE1 Inhibitors Abnormally Increase the BACE1 Protein in Neurons by Prolonging its Half-life

doi: 10.1016/j.jalz.2019.06.3918

Figure Lengend Snippet: (A) Cellular BACE1 levels were measured by immunoblot after treatment of HEK293-sw cells with 25 μg/ml cycloheximide together with either DMSO or 2.5 μM AZD3293 for 0.5, 1, 2, 4 and 6 h. α-Tubulin serves as loading control. (B-C) Cellular BACE1 levels were measured by ELISA after treatment of HEK293-sw cells with 25 μg/ml cycloheximide together with either DMSO or 0.1 μM L685,458 (negative control) or else 0.1 μM of six different BACE1 inhibitors (LY2811376, AZD3839, AZD3293, PF −06751979, Inhibitor IV, E2609) for 0.5, 1, 2, 4 and 6 h. (n=3; means +/− SD) (D) BACE1 ELISA of FPLC fractions from HEK293-sw cells treated with AZD3293 for 24 h or else AZD3293 for 24 h followed by another 24 h wash out with medium only (n=2; means +/− SD). (E) Cellular BACE1 level were measured by immunoblot after treatment of rat primary cortical neurons (DIV15) with 25 μg/ml cycloheximide plus DMSO or 2.5 μM AZD3293 for 0.5, 1, 2, 4 and 6 h. SNAP25 serves as loading control.

Article Snippet: LY2886721, LY2811376, AZD3293, AZD3839, MK-8931, Pepstatin A, TAPI-1, Batimastat and DAPT were from Selleckchem; E2609 was from Sun-Shine Chemical; PF-06751979 was from MedChemExpree; β-secretase inhibitor IV was from Millipore; GI 254023X was from TOCRIS; Roburic acid was from Aobious; synthetic β-amyloid peptides are all from Anasepc; and recombinant human BACEl and BACE2 protein was from R&D system.

Techniques: Western Blot, Enzyme-linked Immunosorbent Assay, Negative Control

Elemental Composition, Molecular Ions, Retention Times (RTs), LODs, REs, ME, and Suppliers of the Compounds Included in sections S0, S1, S2, and S3 of the WADA List and of the Confounding Factors

Journal: ACS Omega

Article Title: UHPLC–HRMS Method for the Simultaneous Screening of 235 Drugs in Capillary Blood for Doping Control Purpose: Comparative Evaluation of Volumetric and Non-volumetric Dried Blood Spotting Devices

doi: 10.1021/acsomega.2c01417

Figure Lengend Snippet: Elemental Composition, Molecular Ions, Retention Times (RTs), LODs, REs, ME, and Suppliers of the Compounds Included in sections S0, S1, S2, and S3 of the WADA List and of the Confounding Factors

Article Snippet: enarodustat , C 17 H 16 N 4 O 4 , [M + H] + 341.12443 , 9.2 , 1.5 , 63 ± 10 , 25 , MedChemExpress (MCE) (D.B.A. Milano, Italy).

Techniques: