HY-107423 Search Results


ay 9944  (MedChemExpress)
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MedChemExpress ay 9944
Ay 9944, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mz1  (MedChemExpress)
94
MedChemExpress mz1
Mz1, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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chemical inhibitors for jak1  (MedChemExpress)
94
MedChemExpress chemical inhibitors for jak1
Inhibition of TSG-6 expression by JAK <t>inhibitors.</t> Cells were treated with JAK inhibitors (10 µM each of <t>JAK1</t> and JAK2 inhibitor) 20 min prior to cytokine treatment or coculture. Cell lysates were recovered 48 h after stimulation, and TSG-6 expression was analyzed using immunoblotting. ( A ) TSG-6 expression in ASCs after treatment with TNF-α, IL-1β, and/or IFN-γ + LPS. TSG-6 expression in ASCs ( B ) or macrophages ( C ) after coculture. The data shown represent one of three independent experiments. ** p ≤ 0.01 and *** p < 0.001. Inh., inhibitor.
Chemical Inhibitors For Jak1, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 94 stars, based on 1 article reviews
chemical inhibitors for jak1 - by Bioz Stars, 2026-02
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pf3644022 p38 inhibitor neflamapimod medchemexpress hy 10328 jnk inhibitor  (MedChemExpress)
94
MedChemExpress pf3644022 p38 inhibitor neflamapimod medchemexpress hy 10328 jnk inhibitor
Inhibition of TSG-6 expression by JAK <t>inhibitors.</t> Cells were treated with JAK inhibitors (10 µM each of <t>JAK1</t> and JAK2 inhibitor) 20 min prior to cytokine treatment or coculture. Cell lysates were recovered 48 h after stimulation, and TSG-6 expression was analyzed using immunoblotting. ( A ) TSG-6 expression in ASCs after treatment with TNF-α, IL-1β, and/or IFN-γ + LPS. TSG-6 expression in ASCs ( B ) or macrophages ( C ) after coculture. The data shown represent one of three independent experiments. ** p ≤ 0.01 and *** p < 0.001. Inh., inhibitor.
Pf3644022 P38 Inhibitor Neflamapimod Medchemexpress Hy 10328 Jnk Inhibitor, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 94 stars, based on 1 article reviews
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bay 299  (MedChemExpress)
90
MedChemExpress bay 299
Inhibition of TSG-6 expression by JAK <t>inhibitors.</t> Cells were treated with JAK inhibitors (10 µM each of <t>JAK1</t> and JAK2 inhibitor) 20 min prior to cytokine treatment or coculture. Cell lysates were recovered 48 h after stimulation, and TSG-6 expression was analyzed using immunoblotting. ( A ) TSG-6 expression in ASCs after treatment with TNF-α, IL-1β, and/or IFN-γ + LPS. TSG-6 expression in ASCs ( B ) or macrophages ( C ) after coculture. The data shown represent one of three independent experiments. ** p ≤ 0.01 and *** p < 0.001. Inh., inhibitor.
Bay 299, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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bay 299 - by Bioz Stars, 2026-02
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loxl2 inhibitor  (MedChemExpress)
94
MedChemExpress loxl2 inhibitor
Inhibition of TSG-6 expression by JAK <t>inhibitors.</t> Cells were treated with JAK inhibitors (10 µM each of <t>JAK1</t> and JAK2 inhibitor) 20 min prior to cytokine treatment or coculture. Cell lysates were recovered 48 h after stimulation, and TSG-6 expression was analyzed using immunoblotting. ( A ) TSG-6 expression in ASCs after treatment with TNF-α, IL-1β, and/or IFN-γ + LPS. TSG-6 expression in ASCs ( B ) or macrophages ( C ) after coculture. The data shown represent one of three independent experiments. ** p ≤ 0.01 and *** p < 0.001. Inh., inhibitor.
Loxl2 Inhibitor, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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prostratin  (MedChemExpress)
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MedChemExpress prostratin
Inhibition of TSG-6 expression by JAK <t>inhibitors.</t> Cells were treated with JAK inhibitors (10 µM each of <t>JAK1</t> and JAK2 inhibitor) 20 min prior to cytokine treatment or coculture. Cell lysates were recovered 48 h after stimulation, and TSG-6 expression was analyzed using immunoblotting. ( A ) TSG-6 expression in ASCs after treatment with TNF-α, IL-1β, and/or IFN-γ + LPS. TSG-6 expression in ASCs ( B ) or macrophages ( C ) after coculture. The data shown represent one of three independent experiments. ** p ≤ 0.01 and *** p < 0.001. Inh., inhibitor.
Prostratin, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ic50 concentration zno np  (MedChemExpress)
93
MedChemExpress ic50 concentration zno np
Inhibition of TSG-6 expression by JAK <t>inhibitors.</t> Cells were treated with JAK inhibitors (10 µM each of <t>JAK1</t> and JAK2 inhibitor) 20 min prior to cytokine treatment or coculture. Cell lysates were recovered 48 h after stimulation, and TSG-6 expression was analyzed using immunoblotting. ( A ) TSG-6 expression in ASCs after treatment with TNF-α, IL-1β, and/or IFN-γ + LPS. TSG-6 expression in ASCs ( B ) or macrophages ( C ) after coculture. The data shown represent one of three independent experiments. ** p ≤ 0.01 and *** p < 0.001. Inh., inhibitor.
Ic50 Concentration Zno Np, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Inhibition of TSG-6 expression by JAK inhibitors. Cells were treated with JAK inhibitors (10 µM each of JAK1 and JAK2 inhibitor) 20 min prior to cytokine treatment or coculture. Cell lysates were recovered 48 h after stimulation, and TSG-6 expression was analyzed using immunoblotting. ( A ) TSG-6 expression in ASCs after treatment with TNF-α, IL-1β, and/or IFN-γ + LPS. TSG-6 expression in ASCs ( B ) or macrophages ( C ) after coculture. The data shown represent one of three independent experiments. ** p ≤ 0.01 and *** p < 0.001. Inh., inhibitor.

Journal: International Journal of Molecular Sciences

Article Title: Antifibrotic TSG-6 Expression Is Synergistically Increased in Both Cells during Coculture of Mesenchymal Stem Cells and Macrophages via the JAK/STAT Signaling Pathway

doi: 10.3390/ijms232113122

Figure Lengend Snippet: Inhibition of TSG-6 expression by JAK inhibitors. Cells were treated with JAK inhibitors (10 µM each of JAK1 and JAK2 inhibitor) 20 min prior to cytokine treatment or coculture. Cell lysates were recovered 48 h after stimulation, and TSG-6 expression was analyzed using immunoblotting. ( A ) TSG-6 expression in ASCs after treatment with TNF-α, IL-1β, and/or IFN-γ + LPS. TSG-6 expression in ASCs ( B ) or macrophages ( C ) after coculture. The data shown represent one of three independent experiments. ** p ≤ 0.01 and *** p < 0.001. Inh., inhibitor.

Article Snippet: The reagents used in this study were obtained from the indicated suppliers: IFN-γ, IL-1β, TNF-α, IL-4, IL-13, and TGF-β from R&D Systems (Minneapolis, MN, USA); antibodies against α-SMA (ab7817) from Abcam (Cambridge, UK); antibodies against GAPDH (sc47724) and TSG-6 (sc377277) from Santa Cruz Biotechnology (Santa Cruz, CA, USA); antibodies against STAT1 (9172S), pSTAT1 (9167S), STAT3 (9139S), pSTAT3 (9145S), and Smad2/3 (8685S) from Cell Signaling Technology (Danvers, MA, USA); antibodies against pSmad2/3 (PA5-110155) from ThermoFisher Scientific (Waltham, MA, USA); chemical inhibitors for JAK1 (Abrocitinib, HY-107429; MedChemExpress, Princeton, NJ, USA) and JAK2 (AG-490, S1143; Selleck Chemicals, Houston, TX, USA); scramble and TSG-6 siRNA (Santa Cruz).

Techniques: Inhibition, Expressing, Western Blot