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tcb 2  (MedChemExpress)
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MedChemExpress tcb 2
Effect of the the 5-HT 2A receptor agonists 25CN-NBOH, <t>TCB-2,</t> and psilocybin with or without pretreatment with the 5-HT 2A receptor inverse agonist MDL 100907 and the 5-HT 2C receptor antagonist SB 242084 on conditioned freezing displayed as percentage of time. The doses of MDL 100907 (MDL) and SB 242084 (SB) were 1 mg/kg in all experiments. MDL 100907 (A and C), SB 242084 (B), and the combination of the two (B) were administered 40 minutes prior to testing; 25CN-NBOH (A), TCB-2 (A and B), and psilocybin (C) were administered 30 minutes prior to testing. Bars represent medians ± interquartile range. (A) Number of animals per group = 10. a = P < .05 vs saline; b = P < .01 vs saline; c = P < .001 vs 25CN-NBOH plus MDL 100907. (B) Number of animals per group = 7–9. a = P < .01 vs saline; b = P < .05 vs saline. (C) Number of animals per group = 12. a = P < .01 vs saline; b = P < .01 vs MDL 100907 plus psilocybin.
Tcb 2, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Effect of the the 5-HT 2A receptor agonists 25CN-NBOH, TCB-2, and psilocybin with or without pretreatment with the 5-HT 2A receptor inverse agonist MDL 100907 and the 5-HT 2C receptor antagonist SB 242084 on conditioned freezing displayed as percentage of time. The doses of MDL 100907 (MDL) and SB 242084 (SB) were 1 mg/kg in all experiments. MDL 100907 (A and C), SB 242084 (B), and the combination of the two (B) were administered 40 minutes prior to testing; 25CN-NBOH (A), TCB-2 (A and B), and psilocybin (C) were administered 30 minutes prior to testing. Bars represent medians ± interquartile range. (A) Number of animals per group = 10. a = P < .05 vs saline; b = P < .01 vs saline; c = P < .001 vs 25CN-NBOH plus MDL 100907. (B) Number of animals per group = 7–9. a = P < .01 vs saline; b = P < .05 vs saline. (C) Number of animals per group = 12. a = P < .01 vs saline; b = P < .01 vs MDL 100907 plus psilocybin.

Journal: International Journal of Neuropsychopharmacology

Article Title: A Complex Impact of Systemically Administered 5-HT 2A Receptor Ligands on Conditioned Fear

doi: 10.1093/ijnp/pyab040

Figure Lengend Snippet: Effect of the the 5-HT 2A receptor agonists 25CN-NBOH, TCB-2, and psilocybin with or without pretreatment with the 5-HT 2A receptor inverse agonist MDL 100907 and the 5-HT 2C receptor antagonist SB 242084 on conditioned freezing displayed as percentage of time. The doses of MDL 100907 (MDL) and SB 242084 (SB) were 1 mg/kg in all experiments. MDL 100907 (A and C), SB 242084 (B), and the combination of the two (B) were administered 40 minutes prior to testing; 25CN-NBOH (A), TCB-2 (A and B), and psilocybin (C) were administered 30 minutes prior to testing. Bars represent medians ± interquartile range. (A) Number of animals per group = 10. a = P < .05 vs saline; b = P < .01 vs saline; c = P < .001 vs 25CN-NBOH plus MDL 100907. (B) Number of animals per group = 7–9. a = P < .01 vs saline; b = P < .05 vs saline. (C) Number of animals per group = 12. a = P < .01 vs saline; b = P < .01 vs MDL 100907 plus psilocybin.

Article Snippet: MDL 100907, TCB-2, and 25CN-NBOH were purchased from Tocris (Bristol, UK), escitalopram oxalate was purchased from Shodana Labs (Hyderabad, India), pimavanserin was purchased from MedChem Express (Monmouth Junction, NJ, USA), psilocybin was purchased from Chiron Corporation (Emeryville, CA, USA), and SB 242084 was purchased from Sigma-Aldrich (St. Louis, MO, USA).

Techniques: Saline