B-1065 Search Results


uea1  (Vector Laboratories)
96
Vector Laboratories uea1
Uea1, supplied by Vector Laboratories, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ics goat anti mouse biotin  (Vector Laboratories)
95
Vector Laboratories ics goat anti mouse biotin
Ics Goat Anti Mouse Biotin, supplied by Vector Laboratories, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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biotinylated uea 1 lectin  (Vector Laboratories)
96
Vector Laboratories biotinylated uea 1 lectin
Biotinylated Uea 1 Lectin, supplied by Vector Laboratories, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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primary antibodies targeted ulex europaeus agglutinin  (Vector Laboratories)
95
Vector Laboratories primary antibodies targeted ulex europaeus agglutinin
Primary Antibodies Targeted Ulex Europaeus Agglutinin, supplied by Vector Laboratories, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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biotinylated ulex europaeus agglutinin 1 uea 1 lectin  (Vector Laboratories)
96
Vector Laboratories biotinylated ulex europaeus agglutinin 1 uea 1 lectin
Biotinylated Ulex Europaeus Agglutinin 1 Uea 1 Lectin, supplied by Vector Laboratories, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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biotinylated uea  (Vector Laboratories)
96
Vector Laboratories biotinylated uea
Biotinylated Uea, supplied by Vector Laboratories, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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biotinylated ulex europaeus agglutinin  (Vector Laboratories)
95
Vector Laboratories biotinylated ulex europaeus agglutinin
Biotinylated Ulex Europaeus Agglutinin, supplied by Vector Laboratories, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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fluorescein conjugated gsii lectin  (Vector Laboratories)
95
Vector Laboratories fluorescein conjugated gsii lectin
A. Gross appearance of stomachs from iLgr5;GLI2A mice showing impaired growth of tumors in rapamycin-treated mice when compared to vehicle-treated. B. Decreased antral tumor thickness in rapamycin-treated ( N = 8) versus vehicle-treated ( N = 6) iLgr5;GLI2A mice. Data are expressed as means +/− SEM (*** P = 0.0007). C. Markedly reduced mass of GLI2A-expressing tumor cells as well as GLI2A-negative hyperplastic epithelia in rapamycin-treated iLgr5;GLI2A mice. Insets in right panels show appearance of cells with abundant pale-staining cytoplasm reminiscent of mucin, seen only in tumors from rapamycin-treated mice. D. PAS-Alcian blue staining detects cells containing abundant mucin only in tumor cells from rapamycin-treated mice. E. Immunostaining for the mTOR pathway reporter pS6 is lost in GLI2A-expressing tumor cells as well as hyperplastic gastric epithelia of rapamycin-treated mice, confirming effective blockade of mTOR signaling. F. Immunoblot analysis of tumor lysates from rapamycin-treated mice corroborates pS6 immunostaining results in E), showing nearly complete inhibition of pS6 expression relative to tumors from vehicle-treated mice. In contrast, treatment with rapamycin had minimal effects on pAkt or pStat3 expression. G. Immunostaining for Ki67 and GLI2A in tumors from rapamycin-treated mice revealed a striking reduction in the proliferative compartment of GLI2A-negative epithelial cells, particularly at 11 days post-induction (vertical arrows in left panels). H. In contrast to the undifferentiated vehicle-treated tumors in iLgr5;GLI2A mice, tumor cells from rapamycin-treated mice expressed Muc5ac and <t>GSII-binding</t> mucins. I. Some tumor cells from rapamycin-treated mice aberrantly expressed Muc5ac and bound GSII <t>lectin</t> in the same cell. Scale bars: 100 μm.
Fluorescein Conjugated Gsii Lectin, supplied by Vector Laboratories, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/fluorescein conjugated gsii lectin/product/Vector Laboratories
Average 95 stars, based on 1 article reviews
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biotinylated lectin  (Vector Laboratories)
95
Vector Laboratories biotinylated lectin
A. Gross appearance of stomachs from iLgr5;GLI2A mice showing impaired growth of tumors in rapamycin-treated mice when compared to vehicle-treated. B. Decreased antral tumor thickness in rapamycin-treated ( N = 8) versus vehicle-treated ( N = 6) iLgr5;GLI2A mice. Data are expressed as means +/− SEM (*** P = 0.0007). C. Markedly reduced mass of GLI2A-expressing tumor cells as well as GLI2A-negative hyperplastic epithelia in rapamycin-treated iLgr5;GLI2A mice. Insets in right panels show appearance of cells with abundant pale-staining cytoplasm reminiscent of mucin, seen only in tumors from rapamycin-treated mice. D. PAS-Alcian blue staining detects cells containing abundant mucin only in tumor cells from rapamycin-treated mice. E. Immunostaining for the mTOR pathway reporter pS6 is lost in GLI2A-expressing tumor cells as well as hyperplastic gastric epithelia of rapamycin-treated mice, confirming effective blockade of mTOR signaling. F. Immunoblot analysis of tumor lysates from rapamycin-treated mice corroborates pS6 immunostaining results in E), showing nearly complete inhibition of pS6 expression relative to tumors from vehicle-treated mice. In contrast, treatment with rapamycin had minimal effects on pAkt or pStat3 expression. G. Immunostaining for Ki67 and GLI2A in tumors from rapamycin-treated mice revealed a striking reduction in the proliferative compartment of GLI2A-negative epithelial cells, particularly at 11 days post-induction (vertical arrows in left panels). H. In contrast to the undifferentiated vehicle-treated tumors in iLgr5;GLI2A mice, tumor cells from rapamycin-treated mice expressed Muc5ac and <t>GSII-binding</t> mucins. I. Some tumor cells from rapamycin-treated mice aberrantly expressed Muc5ac and bound GSII <t>lectin</t> in the same cell. Scale bars: 100 μm.
Biotinylated Lectin, supplied by Vector Laboratories, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/biotinylated lectin/product/Vector Laboratories
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biotin uea  (Vector Laboratories)
95
Vector Laboratories biotin uea
A. Gross appearance of stomachs from iLgr5;GLI2A mice showing impaired growth of tumors in rapamycin-treated mice when compared to vehicle-treated. B. Decreased antral tumor thickness in rapamycin-treated ( N = 8) versus vehicle-treated ( N = 6) iLgr5;GLI2A mice. Data are expressed as means +/− SEM (*** P = 0.0007). C. Markedly reduced mass of GLI2A-expressing tumor cells as well as GLI2A-negative hyperplastic epithelia in rapamycin-treated iLgr5;GLI2A mice. Insets in right panels show appearance of cells with abundant pale-staining cytoplasm reminiscent of mucin, seen only in tumors from rapamycin-treated mice. D. PAS-Alcian blue staining detects cells containing abundant mucin only in tumor cells from rapamycin-treated mice. E. Immunostaining for the mTOR pathway reporter pS6 is lost in GLI2A-expressing tumor cells as well as hyperplastic gastric epithelia of rapamycin-treated mice, confirming effective blockade of mTOR signaling. F. Immunoblot analysis of tumor lysates from rapamycin-treated mice corroborates pS6 immunostaining results in E), showing nearly complete inhibition of pS6 expression relative to tumors from vehicle-treated mice. In contrast, treatment with rapamycin had minimal effects on pAkt or pStat3 expression. G. Immunostaining for Ki67 and GLI2A in tumors from rapamycin-treated mice revealed a striking reduction in the proliferative compartment of GLI2A-negative epithelial cells, particularly at 11 days post-induction (vertical arrows in left panels). H. In contrast to the undifferentiated vehicle-treated tumors in iLgr5;GLI2A mice, tumor cells from rapamycin-treated mice expressed Muc5ac and <t>GSII-binding</t> mucins. I. Some tumor cells from rapamycin-treated mice aberrantly expressed Muc5ac and bound GSII <t>lectin</t> in the same cell. Scale bars: 100 μm.
Biotin Uea, supplied by Vector Laboratories, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/biotin uea/product/Vector Laboratories
Average 95 stars, based on 1 article reviews
biotin uea - by Bioz Stars, 2026-03
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biotinylated ulex europeus agglutinin i lectin  (Vector Laboratories)
95
Vector Laboratories biotinylated ulex europeus agglutinin i lectin
A. Gross appearance of stomachs from iLgr5;GLI2A mice showing impaired growth of tumors in rapamycin-treated mice when compared to vehicle-treated. B. Decreased antral tumor thickness in rapamycin-treated ( N = 8) versus vehicle-treated ( N = 6) iLgr5;GLI2A mice. Data are expressed as means +/− SEM (*** P = 0.0007). C. Markedly reduced mass of GLI2A-expressing tumor cells as well as GLI2A-negative hyperplastic epithelia in rapamycin-treated iLgr5;GLI2A mice. Insets in right panels show appearance of cells with abundant pale-staining cytoplasm reminiscent of mucin, seen only in tumors from rapamycin-treated mice. D. PAS-Alcian blue staining detects cells containing abundant mucin only in tumor cells from rapamycin-treated mice. E. Immunostaining for the mTOR pathway reporter pS6 is lost in GLI2A-expressing tumor cells as well as hyperplastic gastric epithelia of rapamycin-treated mice, confirming effective blockade of mTOR signaling. F. Immunoblot analysis of tumor lysates from rapamycin-treated mice corroborates pS6 immunostaining results in E), showing nearly complete inhibition of pS6 expression relative to tumors from vehicle-treated mice. In contrast, treatment with rapamycin had minimal effects on pAkt or pStat3 expression. G. Immunostaining for Ki67 and GLI2A in tumors from rapamycin-treated mice revealed a striking reduction in the proliferative compartment of GLI2A-negative epithelial cells, particularly at 11 days post-induction (vertical arrows in left panels). H. In contrast to the undifferentiated vehicle-treated tumors in iLgr5;GLI2A mice, tumor cells from rapamycin-treated mice expressed Muc5ac and <t>GSII-binding</t> mucins. I. Some tumor cells from rapamycin-treated mice aberrantly expressed Muc5ac and bound GSII <t>lectin</t> in the same cell. Scale bars: 100 μm.
Biotinylated Ulex Europeus Agglutinin I Lectin, supplied by Vector Laboratories, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/biotinylated ulex europeus agglutinin i lectin/product/Vector Laboratories
Average 95 stars, based on 1 article reviews
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Image Search Results


A. Gross appearance of stomachs from iLgr5;GLI2A mice showing impaired growth of tumors in rapamycin-treated mice when compared to vehicle-treated. B. Decreased antral tumor thickness in rapamycin-treated ( N = 8) versus vehicle-treated ( N = 6) iLgr5;GLI2A mice. Data are expressed as means +/− SEM (*** P = 0.0007). C. Markedly reduced mass of GLI2A-expressing tumor cells as well as GLI2A-negative hyperplastic epithelia in rapamycin-treated iLgr5;GLI2A mice. Insets in right panels show appearance of cells with abundant pale-staining cytoplasm reminiscent of mucin, seen only in tumors from rapamycin-treated mice. D. PAS-Alcian blue staining detects cells containing abundant mucin only in tumor cells from rapamycin-treated mice. E. Immunostaining for the mTOR pathway reporter pS6 is lost in GLI2A-expressing tumor cells as well as hyperplastic gastric epithelia of rapamycin-treated mice, confirming effective blockade of mTOR signaling. F. Immunoblot analysis of tumor lysates from rapamycin-treated mice corroborates pS6 immunostaining results in E), showing nearly complete inhibition of pS6 expression relative to tumors from vehicle-treated mice. In contrast, treatment with rapamycin had minimal effects on pAkt or pStat3 expression. G. Immunostaining for Ki67 and GLI2A in tumors from rapamycin-treated mice revealed a striking reduction in the proliferative compartment of GLI2A-negative epithelial cells, particularly at 11 days post-induction (vertical arrows in left panels). H. In contrast to the undifferentiated vehicle-treated tumors in iLgr5;GLI2A mice, tumor cells from rapamycin-treated mice expressed Muc5ac and GSII-binding mucins. I. Some tumor cells from rapamycin-treated mice aberrantly expressed Muc5ac and bound GSII lectin in the same cell. Scale bars: 100 μm.

Journal: Oncotarget

Article Title: Invasive mouse gastric adenocarcinomas arising from Lgr5+ stem cells are dependent on crosstalk between the Hedgehog/GLI2 and mTOR pathways

doi: 10.18632/oncotarget.7182

Figure Lengend Snippet: A. Gross appearance of stomachs from iLgr5;GLI2A mice showing impaired growth of tumors in rapamycin-treated mice when compared to vehicle-treated. B. Decreased antral tumor thickness in rapamycin-treated ( N = 8) versus vehicle-treated ( N = 6) iLgr5;GLI2A mice. Data are expressed as means +/− SEM (*** P = 0.0007). C. Markedly reduced mass of GLI2A-expressing tumor cells as well as GLI2A-negative hyperplastic epithelia in rapamycin-treated iLgr5;GLI2A mice. Insets in right panels show appearance of cells with abundant pale-staining cytoplasm reminiscent of mucin, seen only in tumors from rapamycin-treated mice. D. PAS-Alcian blue staining detects cells containing abundant mucin only in tumor cells from rapamycin-treated mice. E. Immunostaining for the mTOR pathway reporter pS6 is lost in GLI2A-expressing tumor cells as well as hyperplastic gastric epithelia of rapamycin-treated mice, confirming effective blockade of mTOR signaling. F. Immunoblot analysis of tumor lysates from rapamycin-treated mice corroborates pS6 immunostaining results in E), showing nearly complete inhibition of pS6 expression relative to tumors from vehicle-treated mice. In contrast, treatment with rapamycin had minimal effects on pAkt or pStat3 expression. G. Immunostaining for Ki67 and GLI2A in tumors from rapamycin-treated mice revealed a striking reduction in the proliferative compartment of GLI2A-negative epithelial cells, particularly at 11 days post-induction (vertical arrows in left panels). H. In contrast to the undifferentiated vehicle-treated tumors in iLgr5;GLI2A mice, tumor cells from rapamycin-treated mice expressed Muc5ac and GSII-binding mucins. I. Some tumor cells from rapamycin-treated mice aberrantly expressed Muc5ac and bound GSII lectin in the same cell. Scale bars: 100 μm.

Article Snippet: Mucins were also detected using fluorochrome-conjugated lectins: Ulex Europaeus Agglutinin I (UEA I) (#B-1065; Vector Laboratories); and fluorescein-conjugated GSII lectin (Vector Laboratories).

Techniques: Expressing, Staining, Immunostaining, Western Blot, Inhibition, Binding Assay